Midlife cognitive aging in Hispanic/Latinos: Predictors and mechanisms of decline

西班牙裔/拉丁裔中年认知衰老：衰退的预测因素和机制

基本信息

批准号：
10478858
负责人：
RICHARD W ROBINS
金额：
$ 71.63万
依托单位：
FLORIDA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10478858
关键词：
Acculturation Adherence Adult Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Behavioral Biological Markers Brain California Caregivers Clinical Cognition Cognitive Cognitive aging Communities Community Healthcare Complex Data Collection Dementia Diagnosis Discrimination Economics Education Elderly Ethnic group Face Family Financial Hardship Funding Genetic Predisposition to Disease Goals Growth Health Healthcare Systems Hispanic Hispanic Populations Impaired cognition Individual Inflammation Intervention Knowledge Latino Latino Population Longevity Longitudinal Studies Maintenance Measures Mediating Mexican Neurotic Disorders Not Hispanic or Latino Outcome Participant Pathway interactions Patients Pattern Performance Personality Physical activity Physiological Plant Roots Population Population Process Prevalence Prevention Process Research Risk Risk Factors Sampling Smoking Social Interaction Social support Stress Testing Time United States Work cognitive function cognitive testing cost shifting cultural values dementia risk depressive symptoms discounting disorder risk disparity reduction economic cost ethnic difference experience health disparity higher education loved ones middle age mild cognitive impairment modifiable risk neuropathology physical inactivity predictive test pressure prevent preventive intervention processing speed programs protective factors psychosocial resilience social social determinants social disparities social integration socioeconomics trend

项目摘要

PROJECT SUMMARY Individuals from Hispanic/Latino backgrounds have a 50% increased risk of Alzheimer's disease (AD) compared to non-Hispanic white individuals. With the changing demographic trends in the United States, the prevalence of AD in the Hispanic/Latino population is expected to increase nine fold over the next 50 years. In addition to the patient, the burden of AD takes a significant toll on the families of loved ones with dementia, their communities, and the healthcare system. The difference in prevalence of AD is rooted in social disparities rather than differences in genetic vulnerability between Hispanic/Latino and white populations. It is critical to identify the specific social determinants in Hispanic/Latino populations that can be leveraged to develop culturally informed interventions that aim to maintain cognitive health and slow or prevent the progression toward mild cognitive impairment and clinical dementia. Midlife is a particularly important, yet understudied, period of the lifespan for cognitive aging. Prevention and intervention efforts are likely to be more effective if started before significant neuropathology accumulates in the brain. The objective of this proposal is to identify midlife factors and associated processes that contribute to health disparities in cognitive decline and risk of dementia. We will leverage an existing longitudinal study of midlife adults – the California Families Project – to couple more than 10 years of repeated assessments across middle adulthood with new data collection on the risk/protective factors and cognitive outcomes. This project will test socioeconomic (e.g., education, financial hardship), personality (e.g., neuroticism, conscientiousness), social (e.g., discrimination, social support), and acculturation (e.g., cultural values, acculturative stress) risk/protective factors for cognitive functioning in midlife Hispanic/Latino adults and the behavioral (e.g., physical inactivity, smoking), psychosocial (e.g., depressive symptoms, delay discounting), and physiological (e.g., inflammation, cellular biomarkers) mechanisms that explain these associations. This work will lead to new knowledge on midlife predictors of cognition and risk of AD, identify social determinants and pathways that create and sustain health disparities for Hispanic/Latino populations, and point to new prevention and intervention targets for promoting healthy cognitive aging in midlife and beyond.

项目概要西班牙裔/拉丁裔背景的人患阿尔茨海默病 (AD) 的风险增加 50% 与非西班牙裔白人相比，随着美国人口趋势的变化，预计未来 50 年，西班牙裔/拉丁裔人群中 AD 的患病率将增加九倍。除了患者之外，AD 的负担也给患有痴呆症的亲人的家人带来了巨大的损失， AD 患病率的差异根源于社会差异。而不是西班牙裔/拉丁裔和白人之间的遗传脆弱性差异至关重要。确定西班牙裔/拉丁裔人口中可用于发展的特定社会决定因素旨在维持认知健康并减缓或阻止进展的文化干预措施轻度认知障碍和临床痴呆是一个特别重要但尚未得到充分研究的问题。认知老化的预防和干预工作可能会更有效。在大脑中积累重要的神经病理学之前就开始了该提议的目的是确定。导致认知能力下降和风险的健康差异的中年因素和相关过程我们将利用现有的中年成年人纵向研究——加州家庭项目——来将 10 多年的中年期重复评估与新的数据收集相结合该项目将测试社会经济（例如教育、财务）。困难）、个性（例如神经质、尽责性）、社会性（例如歧视、社会支持）以及文化适应（例如文化价值观、文化压力）中年认知功能的风险/保护因素西班牙裔/拉丁裔成年人和行为（例如，缺乏身体活动、吸烟）、心理社会（例如，抑郁）症状、延迟贴现）和生理（例如炎症、细胞生物标志物）机制解释这些关联。这项工作将带来关于中年认知和风险预测因素的新知识。 AD，确定造成和维持西班牙裔/拉丁裔健康差异的社会决定因素和途径人口，并指出促进健康认知老龄化的新预防和干预目标中年及以后。