NeuroHIV and Community Partnership and Disparity Core for Institution # 269291

NeuroHIV 和社区伙伴关系以及机构的差异核心

• 批准号: 10475409
• 负责人: Wilson Vincent
• 金额: $ 25万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-05 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475409
• 关键词: AIDS/HIV problem; Address; Affect; Applications Grants; Awareness; Basic Science; Bioinformatics; Caring; Cellular biology; Clinical; Clinical Research; Communication; Communities; Complement; Consultations; Continuity of Patient Care; Development; Discipline; Disease; Fostering; Goals; HIV; HIV diagnosis; Impairment; Infection; Infrastructure; Institution; Intervention; Knowledge; Manuscripts; Memory; Mental Depression; Mentors; Mentorship; Needs Assessment; Neurobehavioral Manifestations; Neurocognitive; Neurocognitive Deficit; Office of Administrative Management; Participant; Persons; Population; Positioning Attribute; Poverty; Prevention; Publications; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Risk; Science; Scientist; Services; Sexual and Gender Minorities; Social Work; Time; Translating; Translational Research; Twitter; Underrepresented Minority; Underrepresented Populations; Universities; Viral; Viral Genes; Viremia; Work; antiretroviral therapy; base; community engaged research; community engagement; community partnership; comorbidity; cultural competence; executive function; experience; gender minority group; health care service; health disparity; health inequalities; innovation; interdisciplinary collaboration; marginalized population; member; minority investigator; neuroAIDS; neurobehavioral; patient population; prevent; racial and ethnic; recruit; service providers; social determinants; social health determinants; social media; social stigma; symposium; synergism; treatment adherence; web page

SUMMARY Despite many people with HIV (PWH) having well-suppressed infection with antiretroviral treatment (ART), some populations of PWH experience disparities in their engagement in the HIV care continuum from timely HIV diagnosis to viral suppression. These disparities, particularly the delayed initiation of ART and disruptions to HIV care and ART adherence, may place populations deemed at risk or hard to reach at further risk of neuroHIV- related complications, including neurocognitive impairments and neurobehavioral sequelae as well as other comorbid clinical problems. Reducing HIV-related health disparities and health inequities is one of the four goals of the National HIV/AIDS Strategy. The Comprehensive NeuroHIV Center (CNHC) is well-positioned not only to support research that addresses the mechanisms of neuroHIV, but also how to facilitate exciting interdisciplinary collaborations to investigate, prevent, treat, and address disparities that may contribute significantly to neuroHIV- related disease in marginalized populations. By supporting a community-engaged research paradigm, the CNHC will maximize the impact of neuroHIV scientists’ research for populations affected by health disparities while leveraging community members’ expertise about their needs, strengths, and experiences. Thus, in this renewal, we have initiated the NeuroHIV Community Partnership and Disparities Core (NHCPDC) to foster community- partnership and interdisciplinary collaborations that examine, address, and prevent disparities involving neuroHIV. The NHCPDC will aim to (1) conduct a community needs assessment to refine the Core’s research infrastructure services; (2) serve as a primary resource to guide culturally competent research that engages communities and addresses neuroHIV disparities; and (3) disseminate research findings in bidirectional communication with the local and broader community to address neuroHIV disparities. The NHCPDC will work in synergy with the Central Administrative and Management Core to complement its support by aiding research involving neuroHIV disparities; the Developmental Research and Mentorship Core to support a diverse group of researchers and NHCPDC-related studies; and the Clinical and Translational Research Support Core to enhance its services for culturally competent research and expand its recruitment efforts involving underrepresented groups at greater risk of developing neuroHIV; and all Cores, including the Viral Gene Editing and Bioinformatics Core and the Cell Biology and Functional Analysis Core, to help disseminate findings and facilitate community awareness and involvement with respect to the development of neuroHIV. The Core will increase the number of interdisciplinary collaborations and resulting studies and publications. In synergy with the other Cores, the NHCPDC will enhance the quality of the neuroHIV research enterprise by supporting research related to neuroHIV disparities and the continuum of HIV care to prevent, treat, and understand neuroHIV disease in marginalized populations most at risk.

概括 尽管许多艾滋病毒感染者 (PWH) 通过抗逆转录病毒治疗 (ART) 很好地抑制了感染，但有些人 艾滋病毒感染者群体在参与艾滋病毒护理连续过程中与及时艾滋病毒相关的情况存在差异 这些差异，特别是 ART 的延迟启动和 HIV 的破坏。 护理和抗逆转录病毒疗法的依从性，可能会使被认为处于危险或难以达到进一步神经艾滋病毒风险的人群 相关并发症，包括神经认知障碍和神经行为后遗症以及其他 减少与艾滋病毒相关的健康差异和健康不平等是四个目标之一。 国家艾滋病毒/艾滋病战略的综合神经艾滋病毒中心 (CNHC) 不仅能够 支持解决神经艾滋病毒机制的研究，以及如何促进令人兴奋的跨学科研究 合作调查、预防、治疗和解决可能对神经艾滋病毒产生重大影响的差异 通过支持社区参与的研究范式，CNHC 致力于解决边缘化人群的相关疾病问题。 将最大限度地发挥神经艾滋病毒科学家的研究对受健康差异影响的人群的影响，同时 利用社区成员关于他们的需求、优势和经验的专业知识因此，在这次更新中， 我们发起了 NeuroHIV 社区伙伴关系和差异核心 (NHCPDC)，以促进社区- 伙伴关系和跨学科合作，检查、解决和防止涉及的差异 NHCPDC 的目标是 (1) 进行社区需求评估以完善核心研究。 基础设施服务；(2) 作为指导文化相关研究的主要资源； 社区并解决神经艾滋病毒差异；(3) 双向传播研究成果 NHCPDC 将与当地和更广泛的社区进行沟通，以解决神经艾滋病毒差异问题。 与中央行政和管理核心协同，通过协助研究补充其支持 涉及神经艾滋病毒差异；发展研究和指导核心，以支持不同的群体 研究人员和 NHCPDC 相关研究；以及临床和转化研究支持核心，以加强 为具有文化能力的研究提供服务，并扩大涉及代表性不足的招聘工作 罹患神经艾滋病病毒的风险较高的群体；以及所有核心，包括病毒基因编辑和生物信息学 核心以及细胞生物学和功能分析核心，帮助传播研究结果并促进社区发展 核心将增加对神经艾滋病毒发展的认识和参与。 跨学科合作以及由此产生的研究和出版物。 NHCPDC 将通过支持相关研究来提高神经 HIV 研究事业的质量 神经艾滋病毒差异和艾滋病毒护理的连续性，以预防、治疗和了解神经艾滋病毒疾病 面临最高风险的人群。