Investigating the relationship between menthol flavor and nicotine metabolism in African Americans who smoke cigarettes

研究吸烟的非裔美国人的薄荷醇风味与尼古丁代谢之间的关系

基本信息

批准号：
10475019
负责人：
Asti B Jackson
金额：
$ 18.87万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2023-03-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10475019
关键词：
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol Address Adolescent Adult African African American African American population Area Behavior Behavioral Biological Markers Blood Pressure Bupropion Cardiovascular Physiology Cessation of life Characteristics Cigarette Cotinine Data Disease Drug Kinetics Electronic cigarette Explosion FDA approved Fellowship Goals Harm Reduction Health Heart Rate Home Individual Lung Manufacturer Name Measures Menthol Metabolism Nicotine Nicotine Dependence Nicotine Withdrawal Observational Study Outcome Participant Patient Self-Report Pharmacodynamics Phase Pilot Projects Plasma Proxy Public Health Pulse Oximetry Reporting Research Rewards Role Scientist Smoke Smoker Smoking Smoking Behavior Sodium Chloride Spirometry Statistical Data Interpretation Taste Perception Tobacco Tobacco use Toxic effect Toxicant exposure Training United States Vulnerable Populations Youth base cigarette craving cigarette smoke combustible tobacco electronic cigarette use electronic cigarette user electronic liquid experimental study health disparity interest knowledge base lung injury mouse model nicotine gum nicotine patch nicotine replacement nicotine use predicting response primary outcome pulmonary function racial difference response skills smoking cessation smoking-related disease tobacco products tobacco regulation toxicant varenicline volatile organic compound young adult

项目摘要

Project Summary African Americans are more likely than Whites to die from smoking related diseases and are less successful at smoking cessation with the current FDA-approved aids. Thus, this proposal seeks to investigate the use of e- cigarettes on smoking reduction in African American and White smokers. This proposal will elucidate the relationship between nicotine metabolism and nicotine concentrations in e-cigarettes on smoking behavior and toxicant exposure in African American and White smokers. We hypothesize that slow nicotine metabolizers will have higher nicotine plasma levels than normal nicotine metabolizers at all nicotine concentrations and report greater positive subjective effects. Additionally, we hypothesize that slow nicotine metabolizers will be more likely to reduce their smoking with e-cigarettes because studies show slower nicotine metabolizing smokers are more successful on nicotine replacement therapies than normal or fast nicotine metabolizing smokers. The outcomes of the project will provide new information to further develop the knowledge base in understanding which nicotine concentration manufacturers should include in e-liquids to reduce smoking behaviors. Regulatory efforts could cap the nicotine content in e-liquids to reduce the addictive potential of e-cigs to adolescents but provide a harm reduction avenue for smokers, especially African American smokers, to protect overall public health.

项目摘要非裔美国人比白人更有可能因吸烟相关疾病而死，并且在当前的FDA批准艾滋病戒烟。因此，该提案旨在调查电子的使用非裔美国人和白人吸烟者吸烟的香烟。该建议将阐明电子烟中的尼古丁代谢与尼古丁浓度之间的关系在吸烟行为和非裔美国人和白人吸烟者的毒物暴露。我们假设缓慢的尼古丁代谢者会在所有尼古丁浓度下，尼古丁血浆水平高于正常尼古丁代谢剂，并报告更大的积极主观效应。此外，我们假设缓慢的尼古丁代谢者将更多由于研究表明，尼古丁代谢较慢，因此可能会减少吸烟尼古丁替代疗法比正常或快速尼古丁代谢吸烟者更成功。这该项目的成果将提供新的信息，以进一步发展知识基础尼古丁浓度制造商应将其包括在电子液体中，以减少吸烟行为。监管努力可能会在电子液体中限制尼古丁含量，以减少电子烟的上瘾潜力青少年，但为吸烟者，尤其是非洲裔美国吸烟者提供了减少伤害途径，以保护总体公共卫生。