Data & Stats Core

数据

基本信息

批准号：
10475317
负责人：
Michael William Lutz
金额：
$ 39.82万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10475317
关键词：
Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Big Data Biocompatible Materials Bioinformatics Biological Biological Markers Clinical Clinical Data Collaborations Communities Consent Forms Consultations Custom Data Data Analyses Data Collection Data Set Databases Dementia Development Disease Ensure Epidemiology Faculty Genetic Gerontology Grant Image Infrastructure Leadership Longevity Measurement Mediating Mentors Methodology Methods Modeling Participant Prevention Proteomics Publishing Quality Control Reporting Research Research Design Research Personnel Research Project Grants Research Support Sampling Schedule Scientist Security Specimen Statistical Data Interpretation Statistical Study System United States National Institutes of Health Work age related cohort data cleaning data communication data format data management data sharing design education research experience genetic analysis genetic variant genomic data innovation interest large datasets large scale data metabolomics multimodality neuroimaging query tools statistics transcriptomics user-friendly

项目摘要

ABSTRACT - DATA MANAGEMENT AND STATISTICS CORE The Duke/UNC Alzheimer’s Disease Research Center (ADRC) Data Management and Statistics Core provides essential support to advance understanding of Alzheimer’s disease and Alzheimer’s disease-related dementias (AD+ADRD). In support of the Duke/UNC ADRC and the broader dementia research community, the Core will offer two essential functions: integrated data management and statistical/ bioinformatics collaborative expertise. Building on strong infrastructure at Duke and UNC, the Core proposes the following Specific Aims: 1) Provide coordinated and integrated data management capabilities across the Duke/UNC ADRC to allow easy access, tracking, and reporting capabilities for all of the Cores; 2) Provide datasets to the National Alzheimer’s Disease Coordinating Center (NACC), to other collaborative efforts in Alzheimer’s disease discovery and prevention, and to AD+ADRD investigators at Duke/UNC; 3) Provide statistical/bioinformatics design and analysis consultation; 4) Develop statistical/bioinformatics methods to meet the needs of the ADRC and AD+ADRD research community; and 5) Provide educational opportunities and mentoring of investigators, trainees and junior faculty in collaboration with the Research Education Component on statistical and bioinformatics methodologies for AD+ADRD research. The Core’s combination of state-of-the-art, integrated data management applications and comprehensive statistical expertise enable the creation and expansion of high-impact research initiatives at the ADRC, including innovative multimodal research projects pursuing identification of age-related drivers of AD through genetics, metabolomics, gerontology, and neuroimaging.

摘要 - 数据管理和统计核心杜克大学/北卡罗来纳大学阿尔茨海默病研究中心 (ADRC) 数据管理和统计核心提供促进对阿尔茨海默病和阿尔茨海默病相关痴呆症的了解的重要支持 (AD+ADRD) 为了支持杜克大学/北卡罗来纳大学 ADRC 和更广泛的痴呆症研究界，核心将提供两个基本功能：综合数据管理和统计/生物信息学协作专业知识。以杜克大学和北卡罗来纳大学强大的基础设施为基础，核心提出以下具体目标： 1) 提供整个杜克大学/北卡罗来纳大学 ADRC 协调和集成的数据管理功能，以便轻松访问、所有核心的跟踪和报告功能；2) 向国家阿尔茨海默病中心提供数据集协调中心 (NACC)，在阿尔茨海默病发现和预防方面的其他合作努力，以及向杜克大学/北卡罗来纳大学的 AD+ADRD 研究人员提供统计/生物信息学设计和分析咨询； 4）开发统计/生物信息学方法以满足ADRC和AD+ADRD研究的需求社区；5) 为研究者、实习生和初级教师提供教育机会和指导与统计和生物信息学方法的研究教育部分合作 AD+ADRD 研究。The Core 结合了最先进的集成数据管理应用程序和全面的统计专业知识有助于创建和扩大具有高影响力的研究举措 ADRC，包括致力于识别与年龄相关的 AD 驱动因素的创新多模式研究项目通过遗传学、代谢组学、老年学和神经影像学。