Expanding Excellence in Developmental Biology in Oklahoma

扩大俄克拉荷马州发育生物学的卓越水平

基本信息

批准号：
10474288
负责人：
Linda F Thompson
金额：
$ 256.36万
依托单位：
OKLAHOMA MEDICAL RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-03-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10474288
关键词：
Address Advisory Committees Age Aging Animal Model Appointment Area Award Biological Models Biomedical Research Caenorhabditis elegans Cardiovascular system Cell Culture Techniques Cells Centers of Research Excellence Chronic Obstructive Pulmonary Disease Communities Conflict (Psychology)Core Facility Development Developmental Biology Developmental Process Disease Dropout Drosophila genus Environment Epigenetic Process Experimental Models Faculty Fertilization Funding Genome Goals Growth Health Hematopoietic stem cells Human Hyperplasia Immune system Infrastructure Infusion procedures Institution Interdisciplinary Study International Intestines Journals Longevity Mentors Mitochondria Molecular Mucous body substance Mus Natural regeneration Neurodegenerative Disorders Oklahoma Paper Phase Physiological Processes Planarians Positioning Attribute Publications Publishing Regenerative Medicine Research Research Personnel Research Support Resources Scientist Senior Scientist System Systems Development Talents Technology The Sun Time Training Transcriptional Regulation Translating United States National Institutes of Health Universities Work Zebrafish biological adaptation to stress career competitive environment genetic deafness healing human disease induced pluripotent stem cell meetings member mouse model novel therapeutic intervention operation programs recruit success tool trend

项目摘要

ABSTRACT Our overall goal is to strengthen our Developmental Biology COBRE by mentoring five newly-recruited investigators, each studying important questions in Developmental Biology with translational implications. We will build upon our success in Phase I when our COBRE Investigators made important discoveries resulting in 53 published papers (many in high-impact journals), 91 presentations at invited seminars or scientific meetings, and the awarding of more than $9.75 million in external funding, including 3 R01s and a R56. We will also continue to build our infrastructure by strengthening and expanding our scientific Cores. Developmental Biology is fundamental to progress in determining the molecular basis of many diseases, as well as for the rapidly emerging field of regenerative medicine. Our new Junior Investigators will use a variety of experimental model systems to explore fundamental developmental processes that are compromised by disease, or might be manipulated to promote healing. Their research areas include intestinal regeneration (planarians), stress responses and aging (C. elegans), mucous cell hyperplasia leading to chronic obstructive pulmonary disease (human cell culture and mouse models), genetics of deafness (zebrafish), and neurodegenerative diseases (Drosophila). The addition of five new Junior Investigators will help create the critical mass necessary for a sustainable community where Developmental Biologists can flourish. Phase II COBRE support will allow us to implement an ideal program for launching the careers of these new investigators by providing committed mentoring from internal and external scientists, building and maintaining outstanding Core facilities for advancing Developmental Biology research, and integrating the new investigators into the growing Developmental Biology community in Oklahoma. This will be accomplished through the following Specific Aims: Aim 1. To grow our multi-disciplinary research program in Developmental Biology through the nurturing of a talented group of Junior Investigators with outstanding potential to become leaders in their fields Aim 2. To mentor the Junior Investigators, using a combination of senior scientists and recently graduated COBRE Junior Investigators within existing OMRF and University of Oklahoma faculty Aim 3. To form an External Advisory Committee of internationally recognized Developmental Biologists to evaluate the progress of, and offer advice to, the Junior Investigators Aim 4. To maintain and expand Core facilities that will support the research of the Junior Investigators and lay the groundwork for their sustainable operation after COBRE funding ends. Aim 5. To promote scientific interactions among the Junior Investigators and create an environment conducive to investigator retention.

抽象的我们的总体目标是通过指导五名新招募的人员来加强我们的发育生物学 COBRE 研究人员，每个人都研究发育生物学中具有转化意义的重要问题。我们将建立在我们第一阶段成功的基础上，当时我们的 COBRE 研究人员取得了重要发现，导致发表了 53 篇论文（许多发表在高影响力期刊上），在受邀研讨会或科学会议上进行了 91 次演讲会议，并授予超过 975 万美元的外部资金，包括 3 个 R01 和一个 R56。我们将还通过加强和扩大我们的科学核心继续建设我们的基础设施。发育性生物学对于确定许多疾病的分子基础以及治疗疾病的分子基础方面的进展至关重要。再生医学领域迅速崛起。我们新的初级研究员将使用各种实验模型系统来探索受到疾病损害或可能受到影响的基本发育过程被操纵以促进愈合。他们的研究领域包括肠道再生（涡虫）、压力反应和衰老（线虫）、粘液细胞增生导致慢性阻塞性肺病（人类细胞培养和小鼠模型）、耳聋遗传学（斑马鱼）和神经退行性疾病（果蝇）。五名新初级研究员的加入将有助于创造必要的临界质量发育生物学家可以蓬勃发展的可持续社区。第二阶段 COBRE 支持将使我们能够通过提供承诺，实施一个理想的计划来启动这些新调查员的职业生涯内部和外部科学家的指导，建立和维护优秀的核心设施推进发育生物学研究，并将新的研究人员融入不断发展的研究中俄克拉荷马州的发育生物学社区。这将通过以下具体措施来完成目标：目标 1. 通过培养发展生物学的多学科研究项目一群才华横溢的初级研究员，具有成为各自领域领导者的杰出潜力目标 2. 利用资深科学家和刚毕业的科学家的组合来指导初级研究人员现有 OMRF 和俄克拉荷马大学教员中的 COBRE 初级研究员目标 3. 组建一个由国际公认的发育生物学家组成的外部咨询委员会，评估初级调查员的进展并向其提供建议目标 4. 维护和扩展核心设施，以支持初级研究员的研究并奠定基础为 COBRE 资助结束后可持续运营奠定基础。目标 5. 促进初级研究者之间的科学互动并创造有利的环境留住调查员。