Expanding Excellence in Developmental Biology in Oklahoma

扩大俄克拉荷马州发育生物学的卓越水平

基本信息

批准号：
10629614
负责人：
Linda F Thompson
金额：
$ 127.88万
依托单位：
OKLAHOMA MEDICAL RESEARCH FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10629614
关键词：
Address Advisory Committees Age Appointment Area Bioinformatics Biomedical Research Caenorhabditis elegans Cardiovascular system Cell Culture Techniques Cell model Centers of Research Excellence Communities Core Facility Development Developmental Biology Disease Doctor of Philosophy Dropout Drosophila genus Environment Epigenetic Process Faculty Fertilization Funding Future Genome Genomic approach Goals Hematopoietic stem cells Hereditary Disease Human Image Immune system Infrastructure Institution Interdisciplinary Study International Journals Laboratories Mentors Molecular Mus Mutation Oklahoma Pathway interactions Phase Physiological Processes Pilot Projects Planarians Positioning Attribute Productivity Publishing Regenerative Medicine Research Research Personnel Research Support Resources Scientist Senior Scientist Services System Systems Development Time Training United States National Institutes of Health Universities Woman Work Zebrafish career competitive environment functional genomics human disease human model member men model organism novel therapeutic intervention operation programs trend

Address Advisory Committees Age Appointment Area Bioinformatics Biomedical Research Caenorhabditis elegans Cardiovascular system Cell Culture Techniques Cell model Centers of Research Excellence Communities Core Facility Development Developmental Biology Disease Doctor of Philosophy Dropout Drosophila genus Environment Epigenetic Process Faculty Fertilization Funding Future Genome Genomic approach Goals Hematopoietic stem cells Hereditary Disease Human Image Immune system Infrastructure Institution Interdisciplinary Study International Journals Laboratories Mentors Molecular Mus Mutation Oklahoma Pathway interactions Phase Physiological Processes Pilot Projects Planarians Positioning Attribute Productivity Publishing Regenerative Medicine Research Research Personnel Research Support Resources Scientist Senior Scientist Services System Systems Development Time Training United States National Institutes of Health Universities Woman Work Zebrafish career competitive environment functional genomics human disease human model member men model organism novel therapeutic intervention operation programs trend

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项目摘要

ABSTRACT OVERALL Developmental Biology research is fundamental to progress in determining the molecular basis of many diseases, as well as for the rapidly emerging field of regenerative medicine. During COBRE Phases I and II, we welcomed 12 new investigators, many of whom use model organisms (planarians, Drosophila, zebrafish, and C. elegans) whose genomes can be efficiently manipulated to understand fundamental physiological processes that are conserved among species. In some cases, functional genomic approaches were used to model human mutations to understand the basis of devastating inherited diseases. All our Project Leads were rigorously trained in Developmental Biology, published in top tier journals, and showed exceptional promise. Their appointments were deliberately divided among four of OMRF’s Research Programs (equivalent to academic departments) to encourage cross-fertilization and attract established investigators to the field. We now have a critical mass of Developmental Biologists that includes COBRE-supported investigators as well as more established faculty. During Phases I and II we also established and expanded Cores that provide essential services to Developmental Biologists: an Imaging Core and a Bioinformatics and Pathways Core. Our goals in Phase III are to consolidate the progress we have made in Phases I and II by welcoming new Developmental Biologists into our community through the support of Pilot Projects and to expand the services offered by our Cores, while at the same time positioning them for sustainability when COBRE funding ends. We will accomplish our goals through the following Specific Aims. Aim 1. To expand the breadth of our research program in Developmental Biology through the choice of Pilot Project Investigators with outstanding potential to become leaders in their fields. Aim 2. To mentor the Pilot Project Investigators using a combination of senior scientists and recently graduated COBRE Project Leads within existing OMRF and University of Oklahoma faculty. Aim 3. To form an External Advisory Committee of internationally recognized Developmental Biologists to evaluate the progress of, and offer advice to, the Pilot Project Investigators and Core Directors. Aim 4. To expand the capabilities of the Core facilities so they are well-positioned to support the research of both current and future Developmental Biologists (including current Pilot Project Investigators) and lay the groundwork for sustainable operation after COBRE funding ends. Aim 5. To promote scientific interactions among the Pilot Project Investigators and former Project Leads to create an environment conducive to investigator retention.

总体上抽象发育生物学研究对于确定许多人的分子基础的进展至关重要疾病以及迅速新兴的再生医学领域。在I和ii阶段的毛线期间，我们欢迎12位新调查人员，其中许多人使用模型生物（Planarians，果蝇，斑马鱼，和秀丽隐杆线虫），其基因组可以有效地操纵以了解基本生理物种之间组织的过程。在某些情况下，使用功能基因组方法来建模人类突变以了解毁灭性遗传疾病的基础。我们所有的项目线索都是经过严格的发展生物学培训，在顶级期刊上发表，并表现出了非凡的希望。他们的任命是故意在OMRF的四个研究计划中分配的（相当于学术部门）鼓励交叉利用并吸引既定的调查人员进入该领域。我们现在，拥有大量的发育生物学家，包括鞋垫的研究人员以及更既定的教师。在第I和II阶段，我们还建立了和扩展的核心，为发展生物学家：成像核心以及生物信息学和途径核心。我们在第三阶段的目标通过欢迎新的发展生物学家来巩固我们在I和II阶段取得的进展通过支持试点项目的支持并扩大我们的核心提供的服务，然后同时，当毛病资金结束时，将它们定位为可持续性。我们将实现我们的目标通过以下特定目标。目的1。通过选择飞行员，扩大我们在发育生物学领域的研究计划的广度有可能成为其领域领导者的项目调查员。目标2。指导飞行员项目调查人员结合了高级科学家和最近毕业的Cobre Project Leads 在现有的OMRF和俄克拉荷马大学教职员工中。目标3。组成一个外部咨询委员会国际认可的发展生物学家评估并向飞行员提供建议项目调查人员和核心主管。目标4。扩大核心设施的功能，以便它们位置良好，以支持当前和未来发展生物学家的研究（包括当前试点项目调查人员）并在鞋底资金结束后为可持续运营奠定了基础。目的 5。促进试点项目调查人员之间的科学互动，以前的项目导致创建调查员保留的环境。