National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA): Administrative Resource

国家青少年酒精与神经发育联盟 (NCANDA)：行政资源

基本信息

批准号：
10471647
负责人：
SANDRA A BROWN
金额：
$ 56.28万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-05 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10471647
关键词：
21 year old Acute Address Adolescence Adolescent Adolescent and Young Adult Adult Affect Age Alcohol abuse Alcohol consumption Alcohols Authorship Behavioral Biological Brain COVID-19 pandemic effects Career Mobility Clinical Cognition Cognitive Communication Communities Complement Computers Conflict (Psychology)Data Data Analyses Data Collection Development Disputes Economics Elements Emotional Ensure Evaluation Female Functional Magnetic Resonance Imaging Gender Goals Growth Health Sciences Heart Rate Heavy Drinking Home Independent Living Individual International Interview Leadership Learning Life Link Magnetic Resonance Imaging Measures Memory Mission Modeling Monitor National Institute on Alcohol Abuse and Alcoholism Oregon Patient Recruitments Pattern Performance Personal Satisfaction Persons Physical activity Positioning Attribute Procedures Process Protocols documentation Psychopathology Recovery Reporting Research Research Project Grants Resolution Resources Rest Risk Risk Factors Sampling Schools Science Sex Differences Site Site Visit Sleep Sleep disturbances Standardization Stress Structure Symptoms System Technology Testing Training Trust Universities Vision Work Youth addiction alcohol cue alcohol effect alcohol use disorder base behavioral outcome binge drinking career career development cognitive performance cohort cue reactivity data standards deep learning design drinking emerging adult emerging adulthood follow-up gray matter hazardous drinking heart function longitudinal design male medical specialties meetings mobile application modifiable risk multimodal neuroimaging neurodevelopment neuroimaging novel pandemic disease programs prospective relating to nervous system response retention rate social success underage drinking young adult young man young woman

项目摘要

PROJECT SUMMARY Excessive alcohol drinking Initiated during adolescence is known to disturb typical neurodevelopmental patterns, increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood. In response to RFA-AA-21-008, the Administrative Resource (AR) proposes to coordinate activities of the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for the next 5 years a diverse community sample of male and female participants recruited in three age bands (12- 14, 15-17, 18-21 years old) as mostly no-to-low drinkers, tracked over the last 8 years across 5 sites (N=831; 93% retention rate). This consortium reflects seven applications: NCANDA - Administrative Resource (UCSD) and NCANDA - Data Analysis Resource (SRI), and five cross-national Research Project Sites, located at Duke University (Duke), Oregon Health Science University (OHSU), University of Pittsburgh (Pitt), SRI International (SRI), and UC San Diego (UCSD). Monitoring has involved annually multimodal neuroimaging (MRI, DTI, resting state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer and our mobile app. These measures will now be complemented with new advanced neuroimaging and sleep and physical activity tracking. Our accelerated longitudinal design uniquely positions NCANDA-A (ages 18-34) to quantify transient or enduring alcohol-related disturbances in adolescent and early adult neural system growth trajectories and functional concomitants. NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, we investigate the impact of excessive alcohol drinking during adolescence and emerging adulthood on subsequent developmental trajectories of cognitive performance, brain structure and function, and psychopathology. Aim 2 identifies the extent to which alcohol’s effects on brain structure and function resolve or persist during desistance of binge drinking. Aim 3 identifies adolescent biological, environmental, and behavioral factors that forecast excessive drinking during early adulthood. Aim 4 quantifies COVID-19 pandemic impact on alcohol use, stress, and wellbeing. Aim 5 (SRI and Pittsburgh sites) identifies interactions among alcohol use, sleep, and cardiac function. Aim 6 (UCSD, Duke and OHSU sites) determines the extent to which short-term (i.e., 4 weeks) alcohol use discontinuation results in acute improvement in cognition, affect, sleep and resting heart rate, and reversal of structural and functional brain effects of binge alcohol use. For each aim, sex differences will be tested. With longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel information on the enduring and transient effects of adolescent drinking on adult functioning by discovering elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.

项目摘要已知在青少年期间发起的过量饮酒会干扰典型的神经发育模式，增加患者使用饮酒障碍（AUD）的风险，并在成年期加速递送过程。为了响应RFA-AA-21-008，行政资源（AR）提案以协调活动的活动青少年 - 成年（NCANDA -A）的全国性酒精和神经发育联盟遵循未来5年 14、15-17、18-21岁）作为大多数不饮酒者，在过去的8年中追踪了5个地点（n = 831; 保留率为93％）。该财团反映了七个应用程序：NCANDA-行政资源（UCSD） Ncanda-数据分析资源（SRI）和五个位于杜克的跨国研究项目网站俄勒冈州健康科学大学（OHSU）大学（杜克大学），匹兹堡大学（皮特），SRI International （SRI）和加州大学圣地亚哥加州大学（UCSD）。监测涉及每年多峰神经影像学（MRI，DTI，休息）状态fMRI，任务fMRI），认知，临床，行为和生物学数据，亲自收集或远程收集计算机和我们的移动应用程序。这些措施现在将通过新的高级神经影像完成和睡眠和体育锻炼跟踪。我们加速的纵向设计独特地位置Ncanda-a （18-34岁）以量化青少年和早期成人中性的瞬时或持续酒精相关性疾病系统生长轨迹和功能伴随。 NCANDA-A提案四个联盟整个特定的目标和两个专业项目的目标。在AIM 1中，我们调查青少年和成年期间过量饮酒对随后的序列的影响认知表现，大脑结构和功能以及心理病理学的发展轨迹。目标2 确定酒精对大脑结构和功能的影响在目的地期间的影响或持续存在的程度暴饮暴食。 AIM 3标识了预测的青少年生物学，环境和行为因素成年初量饮酒过多。 AIM 4量化了共vid-19对酒精使用，压力，和幸福。 AIM 5（SRI和匹兹堡站点）确定了酒精使用，睡眠和心脏的相互作用功能。 AIM 6（UCSD，Duke和OHSU站点）确定短期（即4周）酒精的程度使用停用的导致认知，影响，睡眠和静息心率以及逆转的急性改善暴饮精饮酒的结构和功能性脑作用。对于每个目标，都将测试性别差异。随着纵向数据收集到这个续签期间成年初期，NCANDA-A将提供新颖的通过发现青少年饮酒对成人功能的持久和短暂影响的信息连接这些动态过程并识别可修改风险因素的元素和机制。