NYU Pediatric Obesity, Metabolism and Kidney Cohort Center

纽约大学儿科肥胖、代谢和肾脏队列中心

基本信息

批准号：
10471965
负责人：
Leonardo Trasande
金额：
$ 804.95万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10471965
关键词：
13 year old 2 year old 6 year old 9 year old Abdomen Academic Medical Centers Age-Years Aluminum Aromatic Polycyclic Hydrocarbons Behavioral Biological Biometry Birth Body measure procedure Cardiovascular system Chemical Exposure Chemicals Child Child Development Child Health Childhood Cohort Studies Collection DNA Methylation Data Data Pooling Development Diethylhexyl Phthalate Discipline Disease Environment Environmental Health Environmental Impact Epidemiology Epigenetic Process Exposure to Failure Fatty acid glycerol esters Fetal Growth Fetal Weight First Pregnancy Trimester Funding Gene Expression Generations Glomerular Filtration Rate Gonadal Steroid Hormones Growth Guide prevention Health Human Infant Development Inflammation Influentials Institution Insulin Resistance International Kidney Left Ventricular Mass Leptin Life Literature Longitudinal Studies Magnetic Resonance Imaging Measurement Measures Metabolic Metabolic dysfunction Metabolism Modeling Municipalities Obesity Organ Organophosphates Outcome Outcome Measure Oxidative Stress Paper Pesticides Physiologic pulse Plastics Population Preconception Care Pregnancy Research Role Sampling School-Age Population Serum Spottings Thick Time Toxicology Urine Weight Gain adiponectin base bisphenol A blood pressure elevation cardiometabolic risk cardiometabolism cohort disability endothelial dysfunction fetal flexibility follow-up gene environment interaction human subject insight kidney dysfunction medical schools metabolic phenotype metabolomics neurodevelopment obesity in children oxidant stress perinatal outcomes phthalates postnatal prenatal exposure programs prospective psychosocial public health relevance recruit social standardize measure urinary

项目摘要

Project Summary Progress in elucidating the role of the environment in child development and disability has been slow and incremental. Nearly all studies have examined relatively small populations of children; considered only one parameter at a time; had little power to examine interactions among chemical, social, and behavioral factors; had limited ability to examine gene–environment interactions; and suffered from brief duration of follow-up. NYU School of Medicine and Erasmus University Medical Center, in partnerships with multiple other institutions, respond to RFA-16-OD-004, presenting four cohorts for inclusion in the Environmental Influences on Child Health Outcomes Program (ECHO). These cohorts are the NYU Children's Environmental Health Study (n~1000, 2016–2018 births, NYU CHES); the Rotterdam-based Generation R Second Cohort (n~1000, 2016–2018 births, GR2); the First Generation R Study (n=1431, 2004–2006 births, GR1); and the Infant Development and Environment Study II (n=717, 2010–2012 births, TIDES). Together, they would comprise ~9% of all human subjects within ECHO. All four cohorts are well suited to examination of perinatal outcomes; upper and lower airway; and neurodevelopment, and offer substantial flexibility in prospective collection and the use of existing biospecimens. Though our proposed aims focus on chemical exposures, our cohorts also take a broad approach to biological, psychosocial, and physical exposures, which are equally influential on health outcomes. GR1 is widely known as a model for ECHO, given its track record of successful implementation, much like Project Viva. Moreover, GR1 measures could be used to evaluate the promise and feasibility of common ECHO exposures and outcome measures for use in more recently established cohorts. First-trimester recruitment and collection of urine samples in each trimester are common to all four cohorts. A unique benefit to inclusion of GR2 is its nesting within Rotterdam's municipal preconception care program, permitting examination of preconceptional exposures (generally unavailable in US cohorts). GR1's unique abdominal MRI, pulse wave velocity, and echocardiographic measures permit studies of end-organ effects. ECHO funding would extend NYU CHES and GR2 through age 2 years, GR1 through age 13 years, and TIDES through age 9 years, examining prenatal exposures in relation to early life trajectories of body mass. The proposed NYU-Erasmus ECHO Pediatric Obesity, Metabolism and Kidney Cohort Center pairs an internationally known leader in children's environmental health (Trasande) with a leader in the Developmental Origins of Health and Disease (Jaddoe) as multiple PIs and leverages extensive expertise in fetal growth, epidemiology, biostatistics, metabolomics, epigenetics among other disciplines that contribute to high-quality execution of synthetic cohort studies, and guide prevention.

项目摘要阐明环境在儿童发育和残疾中的作用方面的进展一直很慢，并且增量。几乎所有研究都检查了相对较少的儿童人群。仅考虑一个一次参数；检查化学，社会和行为因素之间的相互作用几乎没有能力；检查基因与环境相互作用的能力有限。并遭受了短暂的随访时间。纽约大学医学院和伊拉斯mus大学医学中心，与其他多个机构，对RFA-16-OD-004的响应，提出了四个同类群体以纳入环境影响关于儿童健康结果计划（ECHO）。这些队列是纽约大学儿童的环境健康研究（N〜1000，2016–2018 Births，Nyu Ches）;基于鹿特丹的Recons Second Cohort（n〜1000， 2016- 2018年出生，GR2）；第一代R研究（n = 1431，2004-2006出生，GR1）；和婴儿开发与环境研究II（n = 717，2010-2012出生，潮汐）。他们一起完成回声中的所有人类受试者中有9％。这四个队列都非常适合检查围产期结局。上和下气道；和神经发育，并为预期收集提供了实质性的灵活性现有生物测量的使用。尽管我们提议的目的是专注于化学暴露，但我们的同类也采取广泛的方法来对生物，社会心理和身体暴露，对此对健康结果。鉴于其成功的记录，GR1被广泛称为Echo的模型实施，非常类似于Viva项目。此外，GR1措施可用于评估承诺和在最近建立的同类人群中使用的常见回声暴露和结果指标的可行性。每个三个月中的尿液样本的第一孕期和收集都是所有四个队列的共同点。一个将GR2纳入的独特好处是它在鹿特丹的市政先选计划中筑巢，允许检查孕前暴露（通常在美国队列中不可用）。 Gr1的独特之处腹部MRI，脉搏波速度和超声心动图测量允许对最终器官效应进行研究。回声资金将把NYU CHES和GR2扩展到2岁，GR1至13岁，以及潮汐到9岁，检查与早期生命体重轨迹有关的产前暴露。拟议的Nyu-Erasmus Echo儿科肥胖，代谢和肾脏队列中心配对在儿童环境健康（Trasande）的国际知名领导者与发展的领导者健康与疾病的起源（Jaddoe）作为多个PI和胎儿生长方面的广泛专业知识，流行病学，生物统计学，代谢组学，表观遗传学以及其他有助于高质量的学科执行合成队列研究，并指导预防。