Cancer Cell Biology and Signaling Research Program

癌细胞生物学和信号传导研究计划

• 批准号: 10470109
• 负责人: Vivek M Rangnekar
• 金额: $ 2.87万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-08 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10470109
• 关键词: Achievement; Adhesions; Adipocytes; Animal Model; Anoikis; Apoptosis; Appalachian Region; Area; Bacteria; Basic Science; Cancer Burden; Cancer Center; Cancer Center Support Grant; Catchment Area; Cell Survival; Cellular biology; Chloroquine; Climate; Clinic; Clinical Trials; Collaborations; Cytoskeleton; Development; Diabetes Mellitus; Direct Costs; Drosophila genus; Drug Combinations; Engineering; Ensure; Environment; Epithelial; Extracellular Matrix; FDA approved; Faculty; Funding; Future; Gene Proteins; Goals; Grant; Group Meetings; Growth Factor; Immune checkpoint inhibitor; Immunologist; Incidence; Individual; Institutes; Interdisciplinary Study; Intestinal Hormones; Joints; Kentucky; Legal patent; Link; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Medicine; Mentors; Mesenchymal; Mission; Morbidity - disease rate; NCI Center for Cancer Research; National Cancer Institute; Nature; Neoplasm Metastasis; Neurotensin; Obesity; Oral; PAWR gene; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Postdoctoral Fellow; Process; Program Description; Public Health; Publications; Publishing; Regulation; Research; Research Personnel; Research Project Grants; Role; Science; Signal Pathway; Signal Transduction; Stilbenes; System; Testing; Transitional Cell; Translational Research; Translations; Tumor Cell Invasion; Tumor Suppressor Genes; Tumor Suppressor Proteins; Underserved Population; Universities; Zebrafish; base; breast cancer progression; cancer cell; cancer education; cancer initiation; cancer stem cell; cell motility; clinical translation; cohesion; collaborative environment; college; colon cancer treatment; cytokine; drug discovery; gene network; inhibitor; insight; inter-institutional; leukemic stem cell; melanoma; member; mortality; neoplastic cell; new therapeutic target; novel; novel drug combination; novel therapeutics; programs; recruit; resistance mechanism; response; smoothened signaling pathway; stem cell division; stem cells; success; targeted treatment; therapy resistant; tool; translational therapeutics; tumor; tumor microenvironment; tumor progression

PROJECT SUMMARY/ABSTRACT The Markey Cancer Center's Cancer Cell Biology and Signaling (CS) Research Program includes a robust array of thematically driven projects performed by a cohesive and highly collaborative group of investigators. The overarching goal is to better understand cancer signaling networks in order to identify novel targets that can be exploited to create new therapeutic combinations. To achieve this objective, the CS program is divided into 3 thematic areas: 1) Aberrant proliferation and survival networks, 2) Determinants of tumor progression and metastasis, and 3) Interaction of tumor cells with their microenvironment. Inter-related subthemes within each goal reflect the scope of the research projects and individual expertise across the cross-cutting topic of “Cell Signaling.” These include regulation of oncogene/tumor suppressor and kinase/phosphatase gene networks (Theme 1); contribution of cell motility/ epithelial-mesenchymal transition and cancer stem cells to therapeutic resistance (Theme 2); and examination of cellular and matrix contributions to cancer development and progression (Theme 3). Members of the CS program are experts in defining cancer signaling pathways that underlie the mechanisms of cancer cell survival, proliferation, invasion, and metastasis, and deciphering the relationship between the tumor and the micro- and macro-environments that modulate the dynamics of tumor progression. CS members include leaders in the field of survival/apoptosis signaling in response to growth factors/cytokines, adhesion, and anoikis, as well as experts in the processes of epithelial-mesenchymal transition, cell motility, and invasion. The 26 members of the program represent 3 colleges at the University of Kentucky and 9 different departments, reflecting diverse disciplinary perspectives that provided significant new insights into CS program thematic areas. The CS program has a total annual external cancer-related funding of $7.4M ($5.1M annual direct costs, of which $2.4M (48%) is from the National Cancer Institute). Members published 231 publications between 2013 and 2017, of which 90 (39%) are inter-programmatic, 55 (24%) are intra-programmatic, and 134 (58%) are inter-institutional. Led by CS program Co-leaders, Drs. Vivek Rangnekar (an expert in studying cell survival and apoptosis) and Rina Plattner (an expert in tumor invasion and metastasis), CS research focuses on reducing the most serious cancer burdens in Kentucky by identifying novel therapeutic targets in signaling pathways that drive cancer development and progression. In collaboration with other program leaders and Associate Directors for Basic Research and Clinical Translation, research of the CS program has led to 2 new clinical trials and eight new patents. Additionally, working with the Associate Director for Cancer Education and Mentoring, the Co-leaders of the CS program have instituted a robust mentoring system to ensure the success of junior faculty. By bringing a wide array of expertise and programmatic strengths, the CS program collectively provides a rich environment to facilitate multidisciplinary collaboration and builds a productive pipeline for translation of CS science into the clinic.

项目摘要/摘要 Markey Cancer Center的癌细胞生物学和信号传导（CS）研究计划包括一个强大的 由一个凝聚力和高度协作的研究人员进行的一系列主题驱动的主教。 总体目标是更好地了解癌症癌症信号网络，以确定新的目标 可以利用创建新的治疗组合。 分为3个主题领域：1）异常繁殖和生存网络，2）肿瘤计划的决定因素 转移和3）肿瘤细胞与微环境相互关联的相互作用 每个目标都反映了研究项目的范围和个人专业知识跨切割主题的范围 “细胞信号传导。” 网络（主题1）； 治疗性抗性（主题2）； 和PROGRAME 3（主题3）。 这是癌细胞存活，增殖，侵袭和转移的机制的基础 肿瘤与微环境之间的关系 肿瘤计划包括响应生存/凋亡信号传导领域的领导者。 生长因子/细胞因子，粘附和Anoikis，以及Epity-Esensemal过程的专家 该计划的26名成员的过渡，细胞运动和Invision在University 肯塔基州和9个不同的部门，反映了各种各样的纪律视角，提供了重要的新新 CS计划的洞察力。 740万美元（每年510万美元，其中240万美元（48％）来自国家癌症 在2013年至2017年之间发布了231份出版物，其中90个（39％）是程序间的，55（24％）为 杂志内和134个（58％）是​​由CS计划共同领导的 Rangnekar（研究细胞存活和凋亡的专家）和Rina Plattner（肿瘤侵袭专家 和转移），CS研究专注于肯塔基州最严重的癌症负担 新的治疗剂在信号通路中的靶向促进癌症发展和进展的信号通路。 与其他计划领导者和基础研究和清洁翻译副总监合作， CS计划的研究导致了2项新的临床试验和八项新专利。 CS计划的共同领导者癌症教育与指导副主任已有一个 强大的指导系统，以确保初级教师的成功。 编程优势，CS计划共同提供了丰富的环境，以促进多学科 协作并建立了将CS科学转换为诊所的富有成效的管道。