The impact of a resistance training intervention on blood pressure control in older adults with Sarcopenia

阻力训练干预对患有肌肉减少症的老年人血压控制的影响

• 批准号: 10469564
• 负责人: Deepika Laddu
• 金额: $ 17.03万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469564
• 关键词: Address; Adherence; Adult; Aerobic; Affect; Age; Aging; Behavior; Behavior Therapy; Behavioral; Blood Pressure; Cardiovascular Diseases; Cardiovascular system; Chicago; Chronic; Chronic Disease; Clinical; Clinical Data; Clinical Trials; Clinical Trials Design; Complement; Data; Data Analyses; Development Plans; Educational Intervention; Elderly; Endothelium; Environment; Feedback; Foundations; Funding; Future; Gait speed; General Population; Goals; Guidelines; Health Promotion; Health Status; Healthcare; High Prevalence; Hypertension; Illinois; Impairment; International; Intervention; Intervention Studies; Investigation; Knowledge; Learning; Life Style; Link; Literature; Measures; Mediating; Mentors; Mentorship; Methodology; Microcirculation; Muscle; Muscle function; Neurologic Deficit; Participant; Perfusion; Personal Behavior; Physical Performance; Physical activity; Physiological; Pilot Projects; Population; Prevalence; Prevention; Prospective Studies; Public Health; Randomized; Randomized Controlled Trials; Reporting; Research; Research Personnel; Risk; Risk Factors; Role; Sampling; Scheme; Skeletal Muscle; Syndrome; Target Populations; Techniques; Testing; Time; Training; Universities; Vasodilation; Vasodilator Agents; Work; aged; balance testing; base; behavioral health; blood pressure control; blood pressure elevation; blood pressure reduction; cardiovascular disorder risk; career development; clinically significant; cohort; design; disorder prevention; effective therapy; effectiveness evaluation; evidence base; exercise prescription; experience; high risk; high risk population; human old age (65+); hypertensive; improved; insight; intervention participants; longitudinal analysis; muscle strength; novel; physical conditioning; physical inactivity; pilot test; prevent; prospective; recruit; reduced muscle strength; sarcopenia; skills; strength training; therapy design

Project Summary/Abstract The overall goal of the K01 will be to gain mentored career development to enhance Dr. Laddu's ability to become an independent researcher in chronic disease prevention with a focus on developing pragmatic and scalable interventions to lower or control blood pressure (BP) by preventing highly prevalent aging conditions (i.e., sarcopenia and hypertension). The knowledge and experience acquired through (1) clinical trial design and conduct, and (2) behavioral health promotion intervention conduct, including qualitative and quantitative methodologies, will make Dr. Laddu well-equipped to design multifactorial interventions that target behavioral risk factors and influence health status. This premise of this K01 proposal is to address current gaps in the literature regarding the understanding of high BP due to sarcopenia, and provide new evidence for the discernable relationship between low muscle strength and BP in sarcopenia, and effective non-pharmaceutical treatment approaches. In the most scientifically rigorous manner, Dr. Laddu will evaluate the feasibility of recruitment, retention, implementation and adherence to an empirically-based progressive resistance training (PRT) intervention to test its effect on BP in a targeted population of older adults with sarcopenia who are randomized (via block permuted scheme) to the PRT intervention. Built within this randomized control intervention design, Dr. Laddu will further explore reversibility to examine whether muscle strength serves as an intervention target for BP control in sarcopenic adults, which will be more appropriately tested in subsequently well-powered R-level intervention studies. Physiologically plausible mechanisms by which the PRT impacts changes in BP will also be explored through learned techniques by her mentor. Through this practical experience, Dr. Laddu will acquire insights relative to the intra- and inter-personal behaviors and barriers associated with physical activity and health promotion, and learn how to promote actionable, and scalable lifestyle and behavior strategies that are applicable to and older, high-risk population. Experience will be complemented with cross- disciplinary training which will be accomplished through an integrated career development plan that consists of formal coursework and seminars, guidance from her highly skilled senior mentors and guaranteed protected time to gain practical research experience, and leverages the rich environment for research with older adults at the University of Illinois at Chicago. The training and skills acquired through the K01 career development application will strengthen her research trajectory in health promotion and successfully transition to a fully independent investigator. Importantly, this K01 will set the foundation for Dr. Laddu to build a research portfolio focused on identifying solutions that inform current health care guidelines on effective and practical solutions for the prevention, treatment, and management of BP, and BP-related cardiovascular diseases (CVD) among those suffering from muscular deficits or similar debilitating conditions that affect the growing geriatric population.

项目摘要/摘要 K01的总体目标将是获得指导的职业发展，以增强Laddu博士的能力 慢性疾病预防的独立研究人员，重点是发展务实和可扩展性 通过防止高度普遍的衰老条件（即， 肌肉减少症和高血压）。通过（1）临床试验设计获得的知识和经验 行为和（2）行为健康促进干预行为，包括定性和定量 方法论，将使Laddu博士能够设计出针对行为的多因素干预措施 风险因素和影响健康状况。该K01提案的这个前提是解决当前差距 关于理解肌肉减少症引起的高bp的文献，并为 肌肉减少症中低肌肉强度与BP之间的可辨别关系，有效的非药物 治疗方法。 Laddu博士以最科学的严格方式评估 招募，保留，实施和遵守基于经验的渐进抵抗培训 （PRT）干预措施以测试其对核心核心成年人的目标人群的影响 随机（通过块排列的方案）与PRT干预。建立在这个随机控制中 干预设计，Laddu博士将进一步探索可逆性，以检查肌肉力量是否作为 在肌肉减少症成年人中对BP控制的干预目标，随后将进行更适当的测试 驱动良好的R级干预研究。 PRT会影响生理上合理的机制 BP的变化也将通过她的导师通过学习的技术来探索。通过这种实践经验， Laddu博士将获得相对于个人内部和人际关系的见解 体育锻炼和健康促进，并学习如何促进可操作以及可扩展的生活方式和行为 适用于高危人群的策略。经验将与交叉补充 纪律培训将通过一项综合职业发展计划来完成，该计划包括 正式的课程和研讨会，她熟练高级导师的指导以及保证的受保护时间 获得实践研究经验，并利用丰富的环境与老年人的研究 伊利诺伊大学芝加哥大学。通过K01职业发展应用获得的培训和技能 将加强她在健康促进方面的研究轨迹，并成功过渡到完全独立的 研究者。重要的是，该K01将为Laddu博士建立研究组合的基础 确定有关当前有关医疗保健指南的解决方案 BP的预防，治疗和管理以及与BP相关的心血管疾病（CVD） 患有肌肉缺陷或类似的使人衰弱的状况影响不断增长的老年人群。