The impact of a resistance training intervention on blood pressure control in older adults with Sarcopenia

阻力训练干预对患有肌肉减少症的老年人血压控制的影响

• 批准号: 10337878
• 负责人: Deepika Laddu
• 金额: $ 5.4万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10337878
• 关键词: Address; Administrative Supplement; Biometry; Blood Pressure; Blood Vessels; Childbirth; Chronic Disease; Data Analyses; Data Collection; Educational Intervention; Elderly; Ensure; Event; Funding; Goals; Health; Health Promotion; Human Resources; Hypertension; K-Series Research Career Programs; Life; Literature; Manuscripts; Mentors; Methodology; National Heart, Lung, and Blood Institute; Population; Positioning Attribute; Preparation; Productivity; Protocols documentation; Research; Research Activity; Research Personnel; Research Support; Research Training; Resources; Services; Therapeutic; Time; Training; Training Support; Treatment Efficacy; United States National Institutes of Health; blood pressure regulation; career development; disorder prevention; efficacy evaluation; falls; operation; parent grant; preservation; productivity loss; programs; reduced muscle strength; research and development; resistance exercise; response; sarcopenia; strength training

PROJECT SUMMARY/ABSTRACT In response to PA-20-272 (NOT-OD-20-054), this request is submitted for an administrative supplement to the mentored career development award, K01HL148503 funded through the National Heart, Lung, And Blood Institute of the NIH. The proposed supplement falls within the scope of the parent grant, which focuses on addressing current gaps in the literature regarding the understanding of high blood pressure due to sarcopenia and provides new evidence for the discernable relationship between low muscle strength and blood pressure in sarcopenia, and effective non-pharmaceutical treatment approaches. Due to her critical life event, Dr. Laddu is at a critical juncture where time constraints and limited staff to support training and research responsibilities have led to critical gaps in career development and research productivity. The objectives of the supplement are to ensure the continuity of Dr. Laddu’s career development and research training and facilitate transition to research independence, following her critical life event. This application describes the negative implications of Dr. Laddu’s critical life event on her career development and research productivity. This application further outlines Dr. Laddu’s request for additional resources that will be necessary to address gaps in productivity occurring as a direct consequence of her critical life event, and sufficient to facilitate Dr. Laddu’s return to full research productivity by the end of the supplement period. The specific request for supplemental research support is twofold (1) to hire additional personnel to oversee the methodological delivery of day-to-day operations of the study including coordinating study protocol activities and ensuring quality of data collection; (2) to support additional biostatistical services needed to assist with data analyses and manuscript preparation related to Aim 1 and Aim 2 of the parent grant. With support from this Program, Dr. Laddu will be well positioned to fulfill gaps in productivity that occurred as a negative consequence of the critical life event and resume to full research productivity by the end of the supplemental period. Ensuring continuity of research will further support Dr. Laddu’s project milestones and long-term goals of developing more definitely powered R-level applications to evaluate efficacy of the intervention and potential therapeutic mechanisms by which resistance exercise impacts vascular health in older adults with varying debilitating conditions. Importantly, this supplement program will support Dr. Laddu’s efforts to engage in career development and research activities that are critical to increasing her research productivity and scholarly visibility, and for preserving her progress towards research independence as an expert trialist in health promotion and chronic disease prevention in older adult populations.

项目摘要/摘要 为了响应PA-20-272（NOT-OD-20-054），此请求已提交给行政补充 指导的职业发展奖K01HL148503资助了国家心脏，肺和血液 NIH研究所。 解决文献中有关理解肌肉减少症高血压的当前差距 并为低肌肉力量与血液表现之间的可分辨关系提供了新的证据 肌肉减少症和有效的非药物治疗方法。 在关键时刻的限制和有限的支持培训和支柱培训和一些攻击责任的情况下 导致了职业发展和研究生产力的关键差距。 确保Laddu博士的职业发展和研究培训的连续性，并促进过渡到研究 独立之后，她的批判性生活事件描述了Laddu博士的负面影响 关于她的职业发展和研究生产力的关键生活。 拉杜（Laddu 直接涉及她的关键人生活动，足以促进Laddu博士重返完整的研究 在补充期结束时生产力。 双重（1）雇用其他人员来监督日常运营的方法论 研究包含协调的研究协议活动并确保数据收集质量； 与AIM相关的数据分析和手稿准备所需的其他生物统计服务 1和父母赠款的AIM 2。 在生产力中，这是关键生活事件的负面后果，并恢复全面研究 在补充期结束时生产力。 项目里程碑和长期目标，即开发更确定的R级应用程序 干预措施的功效和潜在的治疗机制，耐药性恢复血管的功效 重要的是，老年人的健康状况不同。 拉杜（Laddu）从事批评她的职业发展和研究激活的投射 研究生产力和学术知名度，并保留她在研究独立性方面的进步 在老年人群体中，健康促进和慢性疾病预防的专家试验者。