Comparative Modeling of Lung Cancer Prevention, Early Detection and Treatment Interventions

肺癌预防、早期检测和治疗干预的比较模型

基本信息

批准号：
10469432
负责人：
THEODORE R HOLFORD
金额：
$ 10.16万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-08 至 2022-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10469432
关键词：
Accounting Adopted Adoption Advisory Committees American College of Radiology Biological Markers Cancer Burden Cancer Etiology Cancer Intervention and Surveillance Modeling Network Cessation of life Cigarette Data Decision Making Development Early Diagnosis Early treatment Effectiveness Electronic cigarette Future Genetic Geographic Locations Histology Immunotherapy Incidence Individual Intervention Joints Lung Malignant neoplasm of lung Modeling Outcome Policies Population Population Research Precision therapeutics Prevalence Preventive service Process Recording of previous events Registries Research Research Personnel Resources Risk Risk Factors Schedule Screening Result Smoking Smoking History Source Taxation Taxes Tobacco Tobacco 21 policies United States Work budget impact cancer recurrence cancer survival cancer therapy comparative cost effectiveness cost-effectiveness evaluation electronic cigarette use fight against health warning implementation barriers innovation low and middle-income countries low dose computed tomography lung basal segment lung cancer prevention lung cancer screening mortality personalized approach population health programs public policy on tobacco screening screening guidelines smoking cessation smoking initiation sociodemographic factors targeted treatment tobacco control tobacco products tobacco screening tool working group

项目摘要

Project Summary Abstract Lung cancer remains the leading cause of cancer related mortality in the US and globally— responsible for ~1.8 million deaths annually. As collaborative investigators of the Cancer Intervention and Surveillance Modeling Network (CISNET) Lung Working Group (LWG), we have contributed to the development of US national strategies for reducing the lung cancer burden by quantifying the impact of tobacco control on smoking, lung cancer, and overall mortality, and by evaluating the population benefits and harms of lung cancer screening in the US. Due to ongoing reductions in smoking in the US, lung cancer mortality is projected to continue declining. However, lung cancer is still expected to result in over 4 million deaths over the next 50 years. Thus, in addition to tobacco control efforts, a focus on early detection and treatment interventions will be critical to further reduce the lung cancer burden in the US. Moreover, as new tobacco products, such as e-cigarettes (e-cigs), become more popular, there are concerns that the gains achieved in the fight against smoking could reverse. We propose to continue our work and extend our models to assess the impact of 1) future tobacco control interventions in the ever-changing tobacco market landscape, 2) improvements in lung cancer screening and other emerging early detection strategies, 3) innovations in lung cancer treatment, and importantly, 4) their synergistic interactions on lung cancer rates and overall mortality in the US and globally.

项目摘要摘要肺癌仍然是美国和全球癌症相关死亡率的主要原因 - 每年造成约180万死亡。作为癌症的合作调查员干预和监视建模网络（CISNET）肺部工作组（LWG），我们为减少肺癌的美国国家战略的发展做出了贡献通过量化烟草控制对吸烟，肺癌和整体的影响来负担死亡率，并通过评估肺癌筛查的人口益处和危害我们。由于美国吸烟的持续减少，预计肺癌死亡率将继续下降。但是，仍然预计肺癌将导致超过400万人死亡接下来的50年。除了烟草控制工作外，还重点是早期检测和治疗干预措施对于进一步减少美国的肺癌伯嫩至关重要。此外，随着新型烟草产品（例如电子烟（E-cigs））变得越来越受欢迎，担心在抗吸烟中取得的收益可能会逆转。我们建议继续我们的工作并扩展我们的模型以评估1）未来烟草控制的影响干预不断变化的烟草市场景观，2）肺癌的改善筛查和其他新出现的早期检测策略，3）肺癌的创新治疗，重要的是，4）它们在肺癌发生率和整体上的协同相互作用在美国和全球的死亡率。