RReSTORE: RGC Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration.

RReSTORE：RGC 重建、干细胞移植和视神经再生。

基本信息

批准号：
10469156
负责人：
Thomas Vincent Johnson
金额：
$ 3.5万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10469156
关键词：
Advertisements Amacrine Cells Axon Blindness Brain Cell Death Cell Survival Characteristics Clinical Collaborations Consensus Data Dendrites Development Disease Educational workshop Ensure Ethnic Origin Feedback Fostering Foundations Funding Agency Glaucoma Goals Grant Individual Industry Inner Plexiform Layer Investigation Laboratories Lead Medicine Methods Mission Modeling Molecular Target Natural regeneration Neurons Online Systems Optic Nerve Participant Pathway interactions Patient Recruitments Patients Persons Phase Process Protocols documentation Race Regenerative Medicine Research Personnel Retina Retinal Ganglion Cells Science Scientist Stem cell transplant Strategic Planning Structure Subgroup Synapses Translating Transplantation Underrepresented Minority Vision Visual Visual impairment Work base career cell regeneration clinical translation data sharing experimental study ganglion cell gender diversity innovation insight meetings multidisciplinary myelination optic nerve disorder optic nerve regeneration physically handicapped postsynaptic neurons prevent programs response sight restoration targeted treatment tool virtual vision development visual stimulus

项目摘要

PROJECT SUMMARY Optic nerve regeneration holds potential for restoring vision for millions of patients with glaucoma and other optic neuropathies, currently the world's leading cause of irreversible blindness. RGC replacement poses a formidable challenge because RGCs represent a heterogeneous class of projection neuron spanning great distances while encoding precisely compartmentalized features of visual stimuli. Vision restoration in optic neuropathy necessitates restoring RGC connectivity both within the retina and at multiple retinothalamic targets. While major advancements have been made in attaining regeneration of portions the RGC pathway in isolation, translating these discoveries to viable clinical therapies that target the entire RGC pathway requires collaborative multidisciplinary teams to discuss approaches, share data, and unify protocols. We propose to jumpstart this process by bringing together a group of ~150 investigators with diverse backgrounds and scientific expertise to solve the most pressing questions in optic nerve regeneration. The Retinal ganglion cell Repopulation, Stem cell Transplantation, and Optic Nerve Regeneration (RReSTORe) Workshop will assemble ~150 leading and emerging vision scientists to 1) define and prioritize the most critical challenges and questions related to regenerative medicine for optic nerve disease over the next 5 years and 2) brainstorm innovative tools and experimental approaches to meeting these challenges while fostering opportunities for collaborative scientific investigation among diverse investigators. Collaborative development will occur in three phases. Participants will self-select 5 discussion sections, each co-moderated by a team of senior & junior investigators: 1) RGC development & differentiation; 2) Transplantation methods & models; 3) RGC survival & host interactions; 4) Inner retinal wiring; and 5) Brain connectivity. In Phase I, participants will delineate the most important questions and challenges hindering clinical translation of vision restoration treatments for optic neuropathy, by engaging in a 4-month long virtual discussion that involves iterative, inclusive, consensus building. In Phase II, participants will meet at the RReSTORe workshop to share ideas, insights, and data in a collaborative roundtable discussion to identify tools, models, and experiments that will propel clinical translation of vision restoring optic neuropathy treatments. In Phase III, participants will establish a sustainable, collaborative investigator network that will advance the RGC replacement field, with an emphasis on maximizing diversity of participants. A web-based collaborative platform, facilitating discussions and debriefings, will follow the RReSTORe workshop. A discussion board for conversations and a quarterly webconference will be established and actively moderated indefinitely. We aim to lay the foundation for a large, sustainable, interdisciplinary consortium of investigators from diverse backgrounds and all career stages (especially junior scientists) to communicate and collaboratively work to reach the goal of RGC replacement and regrowth, sustainably beyond the RReSTORe workshop.

项目摘要视神经再生具有恢复数百万青光瘤患者和其他视神经病变，目前是世界上不可逆转的失明的主要原因。 RGC更换提出巨大挑战，因为RGCS代表了跨越的一类投影神经元跨度在编码视觉刺激的精确分隔特征的同时。视力恢复视觉神经病需要恢复视网膜内和多个视网膜内的RGC连接性目标。虽然在获得RGC途径的重新生成方面取得了重大进步隔离，将这些发现转化为针对整个RGC途径的可行临床疗法要求协作多学科团队讨论方法，共享数据并统一协议。我们建议通过汇集一组约150名不同的调查员来开始这一过程背景和科学专业知识，以解决视神经再生中最紧迫的问题。视网膜神经节细胞再生，干细胞移植和视神经再生（RRESTORE）研讨会将组装约150个领导和新兴视野科学家1）定义和确定优先级与视神经疾病再生医学有关的最关键的挑战和问题接下来的5年和2）集思广益创新的工具和实验方法来应对这些挑战同时为各种研究人员培养了合作科学研究的机会。协作发展将分为三个阶段。参与者将自选5个讨论节，每个讨论部分由高级和初级调查人员组成的团队：1）RGC开发与差异化； 2）移植方法＆模型； 3）RGC生存与宿主互动； 4）内部视网膜接线； 5）大脑连通性。在第一阶段，参与者将描述阻碍视力的临床翻译的最重要的问题和挑战通过进行4个月长的虚拟讨论，用于视神经病变的恢复治疗迭代，包容性，共识建设。在第二阶段，参与者将在Rrestore研讨会开会以分享在协作圆桌讨论中，想法，见解和数据，以识别工具，模型和实验这将推动视力恢复视力神经病治疗的临床翻译。在第三阶段，参与者将建立一个可持续的合作调查员网络，该网络将通过强调最大化参与者的多样性。基于网络的协作平台，促进讨论和汇报将遵循RRestore研讨会。讨论委员会进行对话和季度的讨论委员会 WebConference将被建立并无限期地主持。我们的目标是为来自不同背景和所有人的大型，可持续的，跨学科的研究人员职业阶段（尤其是初级科学家）进行交流和协作以实现目标 RGC替代和再生，可持续地超出RRestore研讨会。