Integrated Biological Systems Training in Oncology

肿瘤学综合生物系统培训

基本信息

批准号：
10468154
负责人：
William Patrick Tansey
金额：
$ 35.25万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10468154
关键词：
Oncology Training biological systems

项目摘要

PROJECT SUMMARY The objective of this second renewal of the Integrated Biological Systems Training in Oncology (IBSTO) program is to continue to prepare predoctoral students and postdoctoral fellows for careers in cancer research with comprehensive training in basic and translational research. IBSTO training focuses on basic cellular processes and mechanisms that are shared between cell biology and developmental biology that are critical to understanding how cells become tumorigenic and on how to translate this basic research knowledge to the diagnosis, treatment and prevention of cancer. The IBSTO program takes place in an active and growing environment with state-of–the-art facilities, a vibrant NCI-designated comprehensive cancer center, top-ranked basic science departments, an Interdisciplinary Graduate Program in Biomedical Sciences, and an active Office of Postdoctoral Affairs. In our first nine years, we have recruited 42 outstanding predoctoral and postdoctoral trainees that have been very productive. Trainees have been placed with experienced, well-funded, productive preceptors in an interactive research environment with extensive resources. The three broad areas of experience of our preceptors are in cell biology, developmental biology/genetics and medicine. The goals of our training program are to provide proactive mentoring and oversight, provide cross-discipline education and research, provide training in cutting edge methodology, develop useful academic skills, foster interactions with faculty and other trainees, provide exposure to current cancer research discoveries, and provide exposure to clinical cancer treatment and translational research. In this renewal, we have strengthened our training activities by adding a new IBSTO Day Retreat, a new cross-disciplinary collaboration workshop, and bolstering our clinical/translational cohort of preceptors. We have also added a new External Advisory Board to provide ongoing feedback and evaluation of the program. And we have a new Program Director who has a strong record of basic cancer research and administrative experience. We believe that integrating basic science research training in cell biology, developmental biology and genetics with translational and clinical experience allows a better understanding of the multiple lesions in cellular processes that define cancer, which is critical to diagnosing, treating and eventually preventing of this disease.

项目概要肿瘤学综合生物系统培训 (IBSTO) 第二次更新的目标该计划是继续为博士生和博士后研究员从事癌症职业做好准备 IBSTO 培训侧重于基础研究和转化研究的综合培训。细胞生物学和发育生物学之间共享的细胞过程和机制对于理解细胞如何致瘤以及如何转化这项基础研究至关重要 IBSTO 计划是在癌症的诊断、治疗和预防方面进行的。活跃且不断发展的环境，拥有最先进的设施、充满活力的 NCI 指定综合设施癌症中心、一流的基础科学系、生物医学跨学科研究生项目科学，以及活跃的博士后事务办公室在我们的前九年里，我们已经招募了 42 名博士后。优秀的博士前和博士后实习生非常富有成效。与经验丰富、资金充足、富有成效的导师一起置于互动研究环境中我们的导师拥有丰富的经验，包括细胞生物学、我们的培训计划的目标是提供积极主动的发展生物学/遗传学和医学。指导和监督，提供跨学科教育和研究，提供前沿培训方法，培养有用的学术技能，促进与教师和其他学员的互动，提供接触当前的癌症研究发现，并提供临床癌症治疗和在这次更新中，我们通过增加新的 IBSTO 来加强我们的培训活动。 Day Retreat，一个新的跨学科合作研讨会，并支持我们的临床/转化队列我们还增加了一个新的外部顾问委员会来提供持续的反馈和帮助。我们有一位新的项目主任，他在基础癌症方面有着丰富的经验。我们相信，将基础科学研究培训融入细胞中。生物学、发育生物学和遗传学以及转化和临床经验可以更好地了解定义癌症的细胞过程中的多种病变，这对于诊断至关重要，治疗并最终预防这种疾病。

项目成果

期刊论文数量（37）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

On the cutting edge: post-translational modifications in cytokinesis.

最前沿：胞质分裂的翻译后修饰。

DOI：
10.1016/j.tcb.2011.01.006
发表时间：
2011-05
期刊：
Trends in cell biology
影响因子：
19
作者：
Bohnert KA;Gould KL
通讯作者：
Gould KL

Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex.

酵母RNA Pol II CTD激酶CTDK-1复合物的结构和激活机制。

DOI：
10.1073/pnas.2019163118
发表时间：
2021
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
Xie,Yihu;Lord,ChristopherL;Clarke,BradleyP;Ivey,AustinL;Hill,PateS;McDonald,WHayes;Wente,SusanR;Ren,Yi
通讯作者：
Ren,Yi

Lkb1 regulates granule cell migration and cortical folding of the cerebellar cortex.