Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO)

小儿肌肉骨骼

• 批准号: 10466931
• 负责人: Hermine I Brunner
• 金额: $ 67.88万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-16 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10466931
• 关键词: Address; Adolescent; Adult; Assessment tool; Biological Markers; Biometry; Caring; Child; Childhood; Chronic; Chronic Childhood Arthritis; Clinical Research; Communities; Data; Data Analytics; Data Display; Data Science; Decision Making; Development; Diagnostic; Diagnostic tests; Disease; Environment; Epidemiology; Family; Feasibility Studies; Fibromyalgia; Fostering; Goals; Health; Health Benefit; Image; Informatics; Interdisciplinary Study; Intervention; Investigation; Knowledge; Laboratories; Leadership; Lupus; Magnetic Resonance Imaging; Measurement; Measures; Medical; Medical center; Medicine; Methodology; Methods; Mission; Musculoskeletal; Musculoskeletal Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nature; Outcome; Pain; Patient Outcomes Assessments; Patients; Pediatric Hospitals; Phenotype; Pilot Projects; Population; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Research Training; Resources; Rheumatism; Rheumatology; Science; Services; Statistical Data Interpretation; System; Technology; Testing; Therapeutic; Translational Research; Ultrasonography; United States National Institutes of Health; base; biomechanical test; career; clinical care; clinical center; clinical decision-making; curative treatments; dashboard; data acquisition; data pipeline; disability; disorder control; empowered; evidence base; health related quality of life; imaging modality; improved; innovation; insight; novel; novel marker; outreach program; patient safety; pediatric rheumatic diseases; personalized approach; point of care; precision medicine; programs; protocol development; ranpirnase; research data dissemination; research study; response; shared decision making; societal costs; synergism; tool

ABSTRACT/PROJECT SUMMARY - OVERALL COMPONENT Children with pediatric rheumatic and non-inflammatory musculoskeletal diseases (PMSKD) have an urgent need for evidence-based medical care that considers the striking differences between pediatric and adult populations. To address these gaps in scientific knowledge, we propose to establish a Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO) at the Cincinnati Children' Hospital Medical Center. Objectives of PORTICO will be to promote impactful research in PMSKD, locally and nationally, with a focus on our well-established research programs in juvenile arthritis, lupus and juvenile fibromyalgia. Specific Aims are: Aim 1: To promote innovation and support clinical research with advanced data science, data analytics capabilities, and data pipeline development. Aim 2: To invigorate cross-disciplinary team science of the local but also national community of researchers in PMSKD. Aim 3: To enhance research in PMSKD by developing and offering cutting-edge assessment tools for capturing the benefits of health interventions and delineating PMSKD phenotypes. Advanced imaging services to support PMSKD research (ultrasonography, magnetic resonance imaging, biomechanical assessment) will be provided, new imaging-based methods and scoring systems developed and an interactive dashboards to synthesize information from patient reported assessments, imaging data, novel biomarkers and traditional disease measures developed in support of improved shared medical decision making. Expected result: PORTICO will create a vibrant research environment that fosters productive team science to find answers to important scientific unknowns regarding PMKSD. Innovation will be sought by (1) developing diagnostics for PMSKD (laboratory tests, imaging tests) and testing their integration into clinical care, and (2) advancing evidence-based based therapies, with focus on JIA, cSLE and JFM. Spread of PORTICO findings and increase of the local & national Research Community will be achieved by multisite research studies, PORTICO's Outreach Program, and its Pilot & Feasibility Studies Program. Alignment with the efforts of other CCCRs, other organizations involved in PMSKD research, and the local research environment is anticipated to potentiate spread of ideas and innovation by PORTICO investigators

摘要/项目摘要 - 整体组件 小儿风湿和非炎性肌肉骨骼疾病（PMSKD）的儿童有紧急 需要基于证据的医疗服务，以考虑小儿和成人之间的明显差异 人群。为了解决科学知识的这些差距，我们建议建立儿科肌肉骨骼 ＆Rheumatology创新核心中心（门廊）位于辛辛那提儿童医院医疗中心。 Portico的目标将是在当地和全国范围内促进PMSKD的有影响力的研究，重点是 我们在青少年关节炎，狼疮和幼年纤维肌痛方面建立了良好的研究计划。具体目的是： 目标1：为了促进与高级数据科学的创新和支持临床研究，数据分析 功能和数据管道开发。 目标2：激发本地但国家研究人员社区的跨学科团队科学 PMSKD。 目标3：通过开发和提供捕获尖端评估工具来增强PMSKD的研究 健康干预措施和描述PMSKD表型的好处。高级成像服务以支持 PMSKD研究（超声检查，磁共振成像，生物力学评估）将是 提供的，开发了新的基于成像的方法和评分系统以及交互式仪表板 从患者报告的评估，成像数据，新型生物标志物和传统的信息中综合信息 为支持改进的共同医疗决策而制定的疾病措施。 预期结果：Portico将创建一个充满活力的研究环境，以促进生产团队科学 找到有关PMKSD重要科学未知数的答案。 （1）发展将寻求创新 PMSKD的诊断（实验室测试，成像测试）并测试其整合到临床护理中，（2） 推进基于证据的疗法，重点是JIA，CSLE和JFM。门廊发现的传播 多站点研究将实现本地和国家研究界的增加， Portico的外展计划及其试点与可行性研究计划。与其他努力保持一致 CCCR，参与PMSKD研究的其他组织以及当地研究环境将会 Portico调查人员的思想和创新的增强蔓延