Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO)

小儿肌肉骨骼

基本信息

批准号：
10019332
负责人：
Hermine I Brunner
金额：
$ 69.27万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-16 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10019332
关键词：
Address Adolescent Adult Assessment tool Biological Markers Biomechanics Biometry Caring Child Childhood Chronic Chronic Childhood Arthritis Clinical Research Communities Data Data Analytics Data Display Data Science Decision Making Development Diagnostic Diagnostic tests Disease Environment Epidemiology Family Feasibility Studies Fibromyalgia Fostering Goals Health Health Benefit Image Informatics Interdisciplinary Study Intervention Investigation Knowledge Laboratories Leadership Lupus Magnetic Resonance Imaging Measurement Measures Medical Medical center Medicine Methodology Methods Mission Musculoskeletal Musculoskeletal Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases Nature Outcome Pain Patient Outcomes Assessments Patients Pediatric Hospitals Phenotype Pilot Projects Population Reporting Research Research Design Research Infrastructure Research Personnel Research Support Research Training Resources Rheumatism Rheumatology Science Services Statistical Data Interpretation System Technology Testing Therapeutic Translational Research Ultrasonography United States National Institutes of Health base career clinical care clinical center clinical decision-making curative treatments dashboard data acquisition data pipeline disability disorder control empowered evidence base health related quality of life imaging modality improved innovation insight novel novel marker outreach program patient safety pediatric rheumatic diseases personalized approach point of care precision medicine programs protocol development ranpirnase research data dissemination research study response shared decision making societal costs synergism tool

项目摘要

ABSTRACT/PROJECT SUMMARY - OVERALL COMPONENT Children with pediatric rheumatic and non-inflammatory musculoskeletal diseases (PMSKD) have an urgent need for evidence-based medical care that considers the striking differences between pediatric and adult populations. To address these gaps in scientific knowledge, we propose to establish a Pediatric musculOskeletal & RheumaTology Innovation COre center (PORTICO) at the Cincinnati Children' Hospital Medical Center. Objectives of PORTICO will be to promote impactful research in PMSKD, locally and nationally, with a focus on our well-established research programs in juvenile arthritis, lupus and juvenile fibromyalgia. Specific Aims are: Aim 1: To promote innovation and support clinical research with advanced data science, data analytics capabilities, and data pipeline development. Aim 2: To invigorate cross-disciplinary team science of the local but also national community of researchers in PMSKD. Aim 3: To enhance research in PMSKD by developing and offering cutting-edge assessment tools for capturing the benefits of health interventions and delineating PMSKD phenotypes. Advanced imaging services to support PMSKD research (ultrasonography, magnetic resonance imaging, biomechanical assessment) will be provided, new imaging-based methods and scoring systems developed and an interactive dashboards to synthesize information from patient reported assessments, imaging data, novel biomarkers and traditional disease measures developed in support of improved shared medical decision making. Expected result: PORTICO will create a vibrant research environment that fosters productive team science to find answers to important scientific unknowns regarding PMKSD. Innovation will be sought by (1) developing diagnostics for PMSKD (laboratory tests, imaging tests) and testing their integration into clinical care, and (2) advancing evidence-based based therapies, with focus on JIA, cSLE and JFM. Spread of PORTICO findings and increase of the local & national Research Community will be achieved by multisite research studies, PORTICO's Outreach Program, and its Pilot & Feasibility Studies Program. Alignment with the efforts of other CCCRs, other organizations involved in PMSKD research, and the local research environment is anticipated to potentiate spread of ideas and innovation by PORTICO investigators

摘要/项目摘要 - 总体组成部分患有小儿风湿性和非炎症性肌肉骨骼疾病 (PMSKD) 的儿童面临着紧急的治疗需要基于证据的医疗护理，考虑到儿童和成人之间的显着差异人口。为了解决这些科学知识上的差距，我们建议建立一个儿科肌肉骨骼实验室辛辛那提儿童医院医疗中心的风湿病创新中心 (PORTICO)。 PORTICO 的目标是在地方和全国范围内促进 PMSKD 的有影响力的研究，重点是我们在青少年关节炎、狼疮和青少年纤维肌痛方面完善的研究项目。具体目标是：目标 1：利用先进的数据科学、数据分析促进创新并支持临床研究能力和数据管道开发。目标 2：振兴当地和国家研究人员社区的跨学科团队科学 PMSKD。目标 3：通过开发和提供用于捕获的尖端评估工具来加强 PMSKD 研究健康干预措施的好处和描述 PMSKD 表型。先进的影像服务支持 PMSKD 研究（超声检查、磁共振成像、生物力学评估）将提供了新的基于成像的方法和评分系统，并开发了交互式仪表板综合来自患者报告的评估、成像数据、新型生物标志物和传统的信息制定疾病措施以支持改进共享医疗决策。预期结果：PORTICO 将创造一个充满活力的研究环境，促进富有成效的团队科学寻找有关 PMKSD 的重要科学未知数的答案。创新将通过（1）发展 PMSKD 诊断（实验室测试、影像学测试）并测试其与临床护理的整合，以及 (2) 推进循证疗法，重点关注 JIA、cSLE 和 JFM。 PORTICO 发现的传播地方和国家研究团体的增加将通过多地点研究来实现， PORTICO 的外展计划及其试点和可行性研究计划。与其他人的努力保持一致 CCCR、参与 PMSKD 研究的其他组织以及当地研究环境预计将加强 PORTICO 研究人员的思想和创新传播