Targeting food cue responsiveness for weight loss

针对减肥的食物线索反应

基本信息

批准号：
10466833
负责人：
Kerri N Boutelle
金额：
$ 68.17万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10466833
关键词：
Adult Aftercare Awareness Behavior Behavior Therapy Behavioral Body Weight decreased Body mass index Cognition Coping Skills Cues Data Desire for food Eating Education Effectiveness Energy Intake Environment Exhibits Exposure to Failure Food Goals Gold Hunger Hyperphagia Individual Laboratories Maintenance Measures Mediator of activation protein Medical Modeling Monitor Obesity Overweight Participant Pathway interactions Patient Self-Report Perception Phenotype Physical activity Predisposition Protocols documentation Psychophysiology Randomized Randomized Controlled Trials Regulation Research Risk Factors Satiation Techniques Testing Time Training Treatment Efficacy Weight acceptability and feasibility active comparator adult obesity arm base behavioral phenotyping clinical decision-making craving cue reactivity demographics design dietary restriction eating in absence of hunger efficacy testing follow-up improved novel nutrition obesity treatment programs psychoeducation psychologic recruit response skills training standard care success targeted treatment theories therapy development trait treatment arm treatment effect treatment group treatment program weight loss intervention weight loss program

项目摘要

ABSTRACT Two out of every three adults has overweight or obesity, which is associated with significant medical and psychological consequences. To date, the most successful weight loss treatment is behavioral weight loss (BWL), which includes nutrition and physical activity education, as well as behavior therapy techniques. Although some adults lose weight in these programs, one third to one half do not respond with even bleaker rates of weight loss maintenance over time. These low success rates suggest that there are underlying mechanisms, such as appetitive traits, that may interfere with response to BWL and underscore the critical need to develop targeted models for the treatment of obesity. Our data suggest that high food responsiveness (FR) is a risk factor for failure in BWL. We have developed a new model for the treatment of obesity based on the Behavioral Susceptibility Theory, called Regulation of Cues (ROC), that focuses on decreasing FR and improving satiety responsiveness (SR). In this study, we propose to recruit adults with overweight and obesity who also exhibit high levels of FR to test the efficacy of an enhanced ROC treatment program (ROC+) for this specific behavioral phenotype. We propose a 3 arm randomized controlled trial that will compare ROC+, BWL and an active comparator (AC). We will recruit and randomize 300 adults with overweight and obesity and will assess them at baseline, during treatment, post-treatment, and at 6- and 12-month follow-up. Primary and secondary aims are as follows. Primary Aim 1: Compare ROC+ to AC on body mass index (BMI) over the course of treatment and follow-up. Primary Aim 2: Compare ROC+ to BWL on body mass index (BMI) over the course of treatment and follow-up. Secondary Aim 1: Compare BWL to AC on body mass index (BMI) over the course of treatment and follow-up. Secondary Aim 2: Compare ROC+, BWL and AC on sensitivity to satiety, sensitivity to food cues, inhibition, restriction, caloric intake, and overeating over the course of the treatment and follow-up. Exploratory aim 1: Evaluate effects of mediators (FR, SR, restriction, overeating) and moderators (demographics, baseline BMI) of treatment effects on weight loss over time. This program of research is an important next step in the development of treatments for specific phenotypes of adults with overweight/obesity, and could change the paradigm of obesity treatment for these individuals. This study will contribute to the study of appetitive phenotypes of obesity, will provide a targeted treatment for individuals with high FR, and could inform clinical decision making for adults with obesity.

抽象的三分之二的成年人患有超重或肥胖，这与重大的医疗和健康问题有关。心理后果。迄今为止，最成功的减肥治疗是行为减肥 (BWL)，其中包括营养和身体活动教育，以及行为治疗技术。尽管一些成年人在这些计划中减肥，但三分之一到一半的人没有做出更黯淡的反应随着时间的推移减肥维持率。这些低成功率表明存在潜在的问题机制，例如食欲特征，可能会干扰对 BWL 的反应并强调关键的需要开发治疗肥胖的有针对性的模型。我们的数据表明，高食物反应性 (FR) 是 BWL 失败的风险因素。我们开发了一种治疗肥胖的新模式行为易感性理论，称为线索调节 (ROC)，其重点是降低 FR 和提高饱腹感反应（SR）。在这项研究中，我们建议招募超重和肥胖的成年人他们还表现出高水平的 FR，以测试增强型 ROC 治疗计划 (ROC+) 对此的功效特定的行为表型。我们提出了一项 3 臂随机对照试验，将比较 ROC+、BWL 和一个有源比较器（AC）。我们将招募 300 名超重和肥胖的成年人并对其进行随机分组，在基线、治疗期间、治疗后以及 6 个月和 12 个月的随访时对其进行评估。初级和次要目标如下。主要目标 1：比较 ROC+ 与 AC 的体重指数 (BMI) 治疗过程和随访。主要目标 2：比较 ROC+ 与 BWL 的体重指数 (BMI) 治疗过程和随访。次要目标 1：比较 BWL 与 AC 的体重指数 (BMI) 治疗过程和随访。次要目标 2：比较 ROC+、BWL 和 AC 对饱腹感的敏感度，治疗过程中对食物线索的敏感性、抑制、限制、热量摄入和暴饮暴食和后续行动。探索性目标 1：评估中介因素（FR、SR、限制、暴饮暴食）和随着时间的推移治疗对减肥效果的调节因素（人口统计、基线体重指数）。这个节目的研究是开发针对成人特定表型的治疗方法的重要下一步超重/肥胖，并可能改变这些人的肥胖治疗模式。这项研究将有助于肥胖食欲表型的研究，将为患有肥胖症的个体提供有针对性的治疗高 FR，可以为肥胖成人的临床决策提供信息。