Targeting food cue responsiveness for weight loss

针对减肥的食物线索反应

• 批准号: 10466833
• 负责人: Kerri N Boutelle
• 金额: $ 68.17万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10466833
• 关键词: Adult; Aftercare; Awareness; Behavior; Behavior Therapy; Behavioral; Body Weight decreased; Body mass index; Cognition; Coping Skills; Cues; Data; Desire for food; Eating; Education; Effectiveness; Energy Intake; Environment; Exhibits; Exposure to; Failure; Food; Goals; Gold; Hunger; Hyperphagia; Individual; Laboratories; Maintenance; Measures; Mediator of activation protein; Medical; Modeling; Monitor; Obesity; Overweight; Participant; Pathway interactions; Patient Self-Report; Perception; Phenotype; Physical activity; Predisposition; Protocols documentation; Psychophysiology; Randomized; Randomized Controlled Trials; Regulation; Research; Risk Factors; Satiation; Techniques; Testing; Time; Training; Treatment Efficacy; Weight; acceptability and feasibility; active comparator; adult obesity; arm; base; behavioral phenotyping; clinical decision-making; craving; cue reactivity; demographics; design; dietary restriction; eating in absence of hunger; efficacy testing; follow-up; improved; novel; nutrition; obesity treatment; programs; psychoeducation; psychologic; recruit; response; skills training; standard care; success; targeted treatment; theories; therapy development; trait; treatment arm; treatment effect; treatment group; treatment program; weight loss intervention; weight loss program

ABSTRACT Two out of every three adults has overweight or obesity, which is associated with significant medical and psychological consequences. To date, the most successful weight loss treatment is behavioral weight loss (BWL), which includes nutrition and physical activity education, as well as behavior therapy techniques. Although some adults lose weight in these programs, one third to one half do not respond with even bleaker rates of weight loss maintenance over time. These low success rates suggest that there are underlying mechanisms, such as appetitive traits, that may interfere with response to BWL and underscore the critical need to develop targeted models for the treatment of obesity. Our data suggest that high food responsiveness (FR) is a risk factor for failure in BWL. We have developed a new model for the treatment of obesity based on the Behavioral Susceptibility Theory, called Regulation of Cues (ROC), that focuses on decreasing FR and improving satiety responsiveness (SR). In this study, we propose to recruit adults with overweight and obesity who also exhibit high levels of FR to test the efficacy of an enhanced ROC treatment program (ROC+) for this specific behavioral phenotype. We propose a 3 arm randomized controlled trial that will compare ROC+, BWL and an active comparator (AC). We will recruit and randomize 300 adults with overweight and obesity and will assess them at baseline, during treatment, post-treatment, and at 6- and 12-month follow-up. Primary and secondary aims are as follows. Primary Aim 1: Compare ROC+ to AC on body mass index (BMI) over the course of treatment and follow-up. Primary Aim 2: Compare ROC+ to BWL on body mass index (BMI) over the course of treatment and follow-up. Secondary Aim 1: Compare BWL to AC on body mass index (BMI) over the course of treatment and follow-up. Secondary Aim 2: Compare ROC+, BWL and AC on sensitivity to satiety, sensitivity to food cues, inhibition, restriction, caloric intake, and overeating over the course of the treatment and follow-up. Exploratory aim 1: Evaluate effects of mediators (FR, SR, restriction, overeating) and moderators (demographics, baseline BMI) of treatment effects on weight loss over time. This program of research is an important next step in the development of treatments for specific phenotypes of adults with overweight/obesity, and could change the paradigm of obesity treatment for these individuals. This study will contribute to the study of appetitive phenotypes of obesity, will provide a targeted treatment for individuals with high FR, and could inform clinical decision making for adults with obesity.

抽象的 每三个成年人中有两个具有超重或肥胖，这与大量医疗和 心理后果。迄今为止，最成功的减肥疗法是行为减肥 （BWL），包括营养和体育活动教育以及行为疗法技术。 尽管有些成年人在这些计划中减肥，但三分之一到一半都没有响应 随着时间的推移，减肥率维持速度。这些较低的成功率表明有基础 机制，例如食欲特征，可能会干扰对BWL的反应并强调关键 需要开发目标模型以治疗肥胖。我们的数据表明食物响应率高 （FR）是BWL失败的危险因素。我们已经开发了一种基于肥胖治疗的新模型 行为易感理论，称为提示调节（ROC），重点是减少FR和 提高饱腹感（SR）。在这项研究中，我们建议招募超重和肥胖症的成年人 谁也表现出高水平的FR来测试增强的ROC治疗计划（ROC+）的功效 特定的行为表型。我们提出了一个3臂随机对照试验，该试验将比较ROC+，BWL 和主动比较器（AC）。我们将招募和随机使300名具有超重和肥胖的成年人，并将 在基线，治疗，治疗后以及6个月和12个月的随访中对其进行评估。主要和 次要目标如下。主要目的1：将ROC+与AC在体重指数（BMI）上进行比较 治疗过程和随访。主要目的2：将ROC+与体重指数（BMI）上的BWL进行比较 治疗过程和随访。次要目标1：将BWL与AC在体重指数（BMI）上进行比较 治疗过程和随访。次要目标2：将ROC+，BWL和AC在敏感性上比较AC， 在治疗过程中对食物提示，抑制，限制，热量摄入和暴饮暴食的敏感性 和跟进。探索目的1：评估介体的影响（FR，SR，限制，暴饮暴食）和 随着时间的推移，主持人（人口统计学，基线BMI）对体重减轻的影响。这个程序的 研究是开发针对成年人特定表型的处理的重要下一步 超重/肥胖，可以改变这些人的肥胖治疗范式。这项研究会 有助于研究肥胖的食用表型，将为患有 高FR，可以为肥胖成年人的临床决策提供信息。