Porous Inorganic Framework Thin Film as Drug-Eluting Stent Coating

多孔无机框架薄膜作为药物洗脱支架涂层

• 批准号: 10466877
• 负责人: Fangyuan Tian
• 金额: $ 11.06万
• 依托单位: CALIFORNIA STATE UNIVERSITY LONG BEACH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-11 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10466877
• 关键词: 3-Dimensional; Address; Adverse effects; Balloon Angioplasty; Behavior; Binding Sites; Blood Vessels; Blood flow; Chemicals; Clinical; Communities; Complex; Coronary artery; Development; Diffusion; Dipyridamole; Drug Carriers; Drug Delivery Systems; Drug Implants; Drug Modelings; Drug Monitoring; Endothelium; Environment; Film; Future; Growth; Health; Heart; High Pressure Liquid Chromatography; Hybrids; Hypersensitivity; Ibuprofen; Immersion; Immunosuppressive Agents; Implant; In Vitro; Iron; Knowledge; Leflunomide; Ligands; Mechanics; Metals; Methods; Microscopic; Minority-Serving Institution; Modification; Monitor; Morphology; Oxides; Paclitaxel; Patients; Performance; Persons; Pharmaceutical Preparations; Polymers; Powder dose form; Preparation; Procedures; Property; Reaction; Reporting; Research; Research Activity; Risk; Solid; Spectrum Analysis; Stainless Steel; Stents; Structure; Students; Surface; Techniques; Testing; Therapeutic; Therapeutic Agents; Thinness; Thrombosis; Tissues; Toxic effect; Vascular Diseases; antiproliferative drugs; base; biocompatible polymer; biomaterial compatibility; carboxylate; chemical binding; chemical bond; covalent bond; crosslink; design; drug release kinetics; education research; high risk; implantation; in vivo; insight; mechanical properties; novel therapeutics; restenosis; scaffold; screening; stent thrombosis; time use

Project Summary/Abstract The primary objective of the proposed project is to prepare surface supportive porous inorganic framework thin films that have superior properties for drug delivery. The second objective, which helps with the realization of the first one, is to identify and better understand the chemical and structural features that have the greatest impact on the drug loading and releasing conditions. To accomplish these objectives, the PI proposes to modify and identify suitable surface platforms (with specific chemical features) that can be used to attach selective iron-containing metal organic framework (Fe-MOF) thin films. These biodegradable Fe-MOFs are composed of Fe(III) clusters and various organic ligands as struts forming three-dimensional porous structures. The organic nodes can also serve as binding sites to crosslink with functionalized metal substrates. The drug loading/releasing with surface-supportive Fe-MOF thin films will be examined by spectroscopic and microscopic methods. We will also evaluate the toxicity and mechanical durability of these Fe- MOF coatings. The performance of these iron-containing inorganic frameworks as drug carriers will be studied in vitro using surface techniques. The knowledge acquired from these initial studies will be beneficial for the future in vivo studies of applying these Fe-MOF thin films as potential drug-eluting stent coatings. In addition, the project aims to enhance the scientific understanding of surface and interface interactions between porous hybrid materials and assorted therapeutic agents. These results will lead to new insights and guide the material design for future drug- eluting stents. The proposed research activities will provide excellent health-related research- education opportunities for students in a minority serving institution like ours, which will bring a significant positive impact to our community.

项目概要/摘要 该项目的主要目标是制备表面支撑性多孔无机材料 具有优异的药物输送性能的框架薄膜。第二个目标，即 有助于实现第一个目标，即识别并更好地理解化学和 对药物负载和释放条件影响最大的结构特征。到 为了实现这些目标，PI 建议修改和确定合适的地面平台 （具有特定的化学特征）可用于附着选择性含铁金属有机物 框架（Fe-MOF）薄膜。这些可生物降解的 Fe-MOF 由 Fe(III) 簇组成 以及各种有机配体作为形成三维多孔结构的支柱。有机的 节点还可以作为与功能化金属基材交联的结合位点。该药 表面支撑 Fe-MOF 薄膜的加载/释放将通过光谱检查 和显微方法。我们还将评估这些铁的毒性和机械耐久性 MOF 涂层。这些含铁无机骨架作为药物载体的性能 将使用表面技术进行体外研究。从这些初步研究中获得的知识 将有利于未来应用这些 Fe-MOF 薄膜作为潜在的体内研究 药物洗脱支架涂层。此外，该项目旨在增强对 多孔杂化材料和各种治疗剂之间的表面和界面相互作用 代理。这些结果将带来新的见解并指导未来药物的材料设计 洗脱支架。拟议的研究活动将提供出色的健康相关研究- 为像我们这样的少数族裔服务机构的学生提供教育机会，这将带来 对我们的社区产生了重大的积极影响。