FASEB SRC: The Post-transcriptional Control of Gene Expression Conference: Mechanisms of RNA Decay

FASEB SRC：基因表达转录后控制会议：RNA 衰变机制

• 批准号: 10467761
• 负责人: ANITA H. CORBETT
• 金额: $ 0.65万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-19 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10467761
• 关键词: Address; Animals; Back; Bacteria; Biological Process; Biology; Biomedical Research; COVID-19; COVID-19 pandemic; Cessation of life; Clinical; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communicable Diseases; Communities; Complex; Defect; Degradation Pathway; Development; Educational workshop; Environment; Enzymes; Eukaryota; Evaluation; Faculty; Florida; Fostering; Gene Expression; Gene Expression Regulation; Genetic Diseases; Genetic Transcription; Goals; Hospitalization; Human; Human Genetics; Jupiter; Leadership; Life; Link; Messenger RNA; Modernization; Modification; Molecular Biology; Muscle; Mutation; Organism; Paper; Participant; Pathway interactions; Patients; Portugal; Post-Transcriptional Regulation; Postdoctoral Fellow; Prokaryotic Cells; Protein Biosynthesis; Proteins; RNA; RNA Decay; RNA Degradation; RNA Interference; RNA Processing; RNA Viruses; RNA vaccine; Regulation; Research; Research Personnel; Respondent; STEM field; Schedule; Scientist; Scourge; Senior Scientist; Series; Site; Spinal; Spinal Muscular Atrophy; Structure; Time; Transcriptional Regulation; Virus; Woman; career; career development; clinical application; cost; disease-causing mutation; enzyme pathway; expectation; graduate student; mRNA Decay; meetings; men; pandemic disease; pathogenic bacteria; pathogenic virus; plant fungi; response; senior faculty; symposium; tool; virtual

PROJECT SUMMARY The understanding that RNA degradation is critical for gene expression traces back to 1959 when Pardee, Jacob and Monod demonstrated in a historical paper that there had to be an unstable intermediate directing protein synthesis. More recently, the spectacular use of RNA interference to experimentally degrade specific mRNAs has expanded the applications of understanding RNA decay mechanisms beyond any expectations. The clinical applications in the post-transcriptional regulation/RNA field are only starting to be realized with the initial development of Nusinersen/Spinraza® to successfully treat Spinal Muscular Atrophy and the more recent description of Milasin® to treat a single patient through a personalized RNA therapy. Of course in late 2019 into early 2020, RNA burst on to the global stage in a way we could not have predicted with the COVID-19 RNA virus impacting life as we know it across the globe. Who would or could have guessed that RNA could also represent a potential path back to a new normal via the rapid development and deployment of the first mRNA vaccines. All of these examples highlight why The FASEB meeting on ‘Post-transcriptional Regulation of Gene Expression: Mechanisms of RNA Decay’ is such a timely conference to support at this juncture. This meeting has developed into a unique conference that brings together the leading experts in RNA decay in humans and other metazoan animals, plants, fungi, viruses, and bacteria. This meeting is the 12th is a series of FASEB meetings on this topic where there is a long tradition of sharing key discoveries, building collaborations, and contributing to career development for junior scientists in the field. This meeting, which, after a two year delay due to the global pandemic, will be held June 19-23, 2022 in Jupiter, Florida, is being co-organized by three leaders in the RNA decay field, Dr. Anita H. Corbett from Emory, USA, Dr. Lori Passmore from the MRC in Cambridge UK, and Dr. Cecilia Arraiano from the ITQB/Universidade NOVA de Lisboa, Portugal. Under this leadership, we propose three specific aims: 1) Bring together the RNA degradation field and provide a forum for the presentation and discussion of the latest advances; 2) Provide an inclusive environment for establishing collaborations between researchers studying RNA degradation with different approaches and in different organisms; and 3) Encourage productive interactions between a diverse group of both junior scientists and leaders in the RNA degradation field. In keeping with a meeting goal and a common passion of the organizers, this meeting is organized with a major commitment to inclusive excellence. Among the 35 invited speakers thus far, there are 18 women (51%) and 17 men (49%). Each session is chaired by a co-chair team consisting of a senior scientist and a junior scientist. Among the 18 co-chairs, 11 (61%) are women. We are excited to include five co-chairs who are from groups traditionally underrepresented in STEM fields (28%). The long-term goal is to continue a successful meeting series that addresses modern and timely topics in RNA decay and processing while building a diverse and inclusive community of collaborative scientists and colleagues.

项目摘要 理解RNA降解对于基因表达至关重要，可以追溯到1959年，当时雅各布 Monod在一篇历史论文中证明了必须有一个不稳定的中间引导蛋白 合成。最近，RNA干扰对实验降解特定mRNA的壮观使用 已经扩大了理解RNA衰减机制的应用，超出了任何期望。临床 转录后调节/RNA场中的应用刚刚开始使用初始 Nusinersen/Spinraza®的开发成功治疗脊柱肌肉萎缩和最近 Milasin®的描述通过个性化的RNA疗法来治疗单个患者。当然在2019年底进入 2020年初，RNA以某种方式进入全球阶段，我们无法预测Covid-19 RNA病毒 影响着我们在全球所知的生活。谁会或可能猜到RNA也可以代表 通过快速开发和部署第一种mRNA疫苗的潜在途径回到新的正常状态。全部 在这些示例中，强调了为什么FASEB会议会议上有关基因表达的转录后调节： RNA Decay’的机制是一个及时的会议，可以在此关头支持。这次会议已经发展 进入一个独特的会议，汇集了人类和其他后生动物RNA衰变领先的专家 动物，植物，真菌，病毒和细菌。这次会议是第十二次会议是有关此主题的一系列Faseb会议 在共享关键发现，建立合作和为职业贡献的悠久传统的地方 该领域初级科学家的发展。这次会议，由于全球延迟两年后 大流行将于2022年6月19日至23日在佛罗里达州的木星举行 美国埃默里（Emory）的Anita H. Corbett博士，英国剑桥的MRC的Lori Passmore博士和博士 葡萄牙ITQB/ITQB/Universidade Nova de Lisboa大学的Cecilia Arraiano。在这个领导下，我们建议 三个具体目的：1）将RNA降解领域汇总在一起，并为演示文稿提供论坛 讨论最新进展； 2）提供一个包容性的环境，以建立合作 研究人员使用不同的方法和不同生物体研究RNA降解； 3）鼓励 RNA降解中的一个初级科学家和领导者的潜水员群体之间的生产互动 场地。为了符合会议目标和组织者的共同热情，这次会议是由 对包容性卓越的主要承诺。到目前为止，在35名受邀演讲者中，有18名妇女（51％） 和17人（49％）。每个会议由一个由高级科学家和初中组成的联合主席团队主持 科学家。在18个联合主席中，有11名（61％）是女性。我们很高兴包括五个来自的联合主席 传统上，茎领域中的人为不足（28％）。长期目标是继续成功 会议系列介绍了RNA衰变和处理中的现代和及时主题，同时建立潜水员 以及合作科学家和同事的包容性社区。