Development of upper extremity behavioral assessment methods for reach-and-grasp and physical rehabilitation

开发用于伸手抓握和身体康复的上肢行为评估方法

• 批准号: 10467762
• 负责人: JILL C. HEATHCOCK
• 金额: $ 67.59万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-21 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10467762
• 关键词: Affect; Age; Age-Months; Assessment tool; Behavior; Behavior assessment; Behavioral; Brachial Paresis; Cerebral Palsy; Child; Child Development; Childhood; Childhood stroke; Chiroptera; Clinical; Clinical Assessment Tool; Clinical Research; Clinical Trials; Code; Cognition; Communication; Data; Development; Dimensions; Dose; Environment; Equipment and supply inventories; Exploratory Behavior; Feedback; Foundations; Frequencies; Funding; Future; Gestures; Goals; Hand; Hand functions; Health; Impairment; Individual; Individual Differences; Infant; Knowledge; Language; Life; Lower Extremity; Measurement; Measures; Methodology; Methods; Mission; Motor; Motor Activity; Motor Skills; Movement; National Institute of Neurological Disorders and Stroke; Nervous System Physiology; Neurologic Deficit; Outcome; Outcome Measure; Parents; Paresis; Phase; Physical Function; Physical Rehabilitation; Play; Population; Property; Psychological reinforcement; Psychometrics; Public Health; Randomized Controlled Trials; Recovery; Rehabilitation therapy; Reporting; Reproducibility; Research; Risk; Scientific Advances and Accomplishments; Selection for Treatments; Standardization; Statistical Models; Stroke; Technology; Testing; Time; Toddler; Toy; United States National Institutes of Health; Upper Extremity; Walking; Work; age group; arm; arm movement; base; burden of illness; clinical practice; clinically relevant; cohort; constraint induced movement therapy; cost; data sharing; disability; dosage; evidence base; exercise intensity; feeding; follow-up; grasp; hemiparesis; hemiparetic stroke; improved; indexing; individualized medicine; innovation; longitudinal dataset; motor impairment; neurological rehabilitation; novel; peer; perinatal ischemic stroke; personalized medicine; phase III trial; physically handicapped; prospective; rehabilitation research; remote assessment; response; skills; tool; treatment effect; treatment response; treatment strategy; virtual assessment

The overall goal of this proposal is to develop and advance behavioral assessment methods (BAM) to measure spontaneous reach and grasp in infants and toddlers with and without hemiparetic cerebral palsy. Reach and grasp are critical to promoting healthy development and active engagement with the environment. This proposal focuses on the key period from 8 – 36 months of age when infants rapidly develop upper extremity skills, mobility, cognition, and language; and when hemiparesis-specific treatments, such as constraint-induced movement therapy, can be started. BAM will advance scientific knowledge about typical movements of the arms and hands as well as altered movements in children with hemiparetic cerebral palsy. This will yield a standardized, objective metric that quantifies the distance between impaired and typical development and will expand the precise measurement of treatment-induced recovery. This project includes prospective longitudinal data obtained from typically developing infants and toddlers and leverages video-sharing and support from StrokeNet’s Phase III randomized controlled trial of constraint-induced movement therapy. In AIM 1 we will develop the BAM Index using reach and grasp behaviors in 80 typically developing infants/toddlers and 240 infants/toddlers with perinatal arterial ischemic stroke and hemiparetic cerebral palsy. Videos will be coded for spontaneous reach and grasp frequency, duration, and exploratory behaviors with a common set of objects. Multiple statistical models will be employed to develop four standardized BAM Indices. In AIM 2 we will (a) evaluate the changes of four BAM Indices with 1040 longitudinal videos from the cohorts and (b) establish psychometric properties of the BAM Indices using: the Pediatric Stroke Outcome Measure (Neurological deficit and function); Gross Motor Function Measure-66 (Gross Motor), Bayley Scales of Infant and Toddler Development 4th edition (Fine Motor, Gross Motor, Language, and Cognition subscales), mini- and Assisting Hand Assessment (paretic hand); parent-reported outcome measures (Infant Motor Activity Log, MacArthur-Bates Communicative Developmental Inventories); and a combined clinical/parent outcome measure (Emerging Behaviors Scale). This project has the potential to advance pediatric rehabilitation research by affording a novel, reliable, precise, and sensitive measure of reach and grasp – applicable to hundreds of thousands of children with infant stroke and hemiparetic cerebral palsy. Furthermore, the novel use of data sharing and video coding are imperative for scientific reproducibility, reduction in cost, and will support the ability to improve health and physical function in infants and toddlers with cerebral palsy and other physical disabilities.

该提案的总体目标是开发和推进行为评估方法（BAM） 测量有或没有半脑脑瘫的婴儿和幼儿中的赞助范围和掌握。 覆盖范围和掌握对于促进健康发展和积极参与环境至关重要。 该提案重点是婴儿迅速发展上肢的8至36个月大的关键时期 技能，流动性，认知和语言；当偏瘫特异性治疗（例如约束诱导）时 运动疗法可以开始。 BAM将促进有关武器典型运动的科学知识 脑膜脑瘫儿童的手以及动作的改变。这将产生一个 标准化的客观度量，可量化受损与典型发展之间的距离，并将 扩大治疗诱导的恢复的精确度量。该项目包括前瞻性纵向 从通常开发婴儿和幼儿获得的数据，并利用视频共享和支持 Strokenet的III期随机对照试验对约束诱导的运动疗法的试验。 在AIM 1中，我们将使用覆盖范围并抓住80种通常开发的bam索引 婴儿/幼儿和240名婴儿/幼儿，患有围产期伪影和半脑脑瘫。 视频将被编码为发起的触及范围，并掌握频率，持续时间和探索性行为 共同的对象集。将雇用多个统计模型来开发四个标准化的BAM指数。 在AIM 2中，我们将（a）通过1040个纵向视频评估四个BAM指数的变化 队列和（b）使用：小儿中风结果建立BAM指数的心理测量特性 度量（神经缺陷和功能）；总运动功能度量66（总电机），贝利尺度 婴儿和幼儿发展第四版（精细电机，总电机，语言和认知子量表），微型 并协助手评估（Paretic Hand）；父母报告的结果指标（婴儿运动活动日志， MacArthur-Bates交流发展库存）；以及联合临床/家长结果度量 （新兴行为规模）。 该项目有可能通过提供新颖，可靠的，可靠的，可靠的小儿康复研究 精确和敏感的覆盖范围和掌握 - 适用于成千上万的婴儿儿童 中风和半脑脑瘫。此外，数据共享和视频编码的新颖使用是 必须进行科学生殖，降低成本，并将支持改善健康和 婴儿和其他身体残疾的婴儿和幼儿的身体功能。