Development of upper extremity behavioral assessment methods for reach-and-grasp and physical rehabilitation

开发用于伸手抓握和身体康复的上肢行为评估方法

基本信息

批准号：
10467762
负责人：
JILL C. HEATHCOCK
金额：
$ 67.59万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-21 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10467762
关键词：
Affect Age Age-Months Assessment tool Behavior Behavior assessment Behavioral Brachial Paresis Cerebral Palsy Child Child Development Childhood Childhood stroke Chiroptera Clinical Clinical Assessment Tool Clinical Research Clinical Trials Code Cognition Communication Data Development Dimensions Dose Environment Equipment and supply inventories Exploratory Behavior Feedback Foundations Frequencies Funding Future Gestures Goals Hand Hand functions Health Impairment Individual Individual Differences Infant Knowledge Language Life Lower Extremity Measurement Measures Methodology Methods Mission Motor Motor Activity Motor Skills Movement National Institute of Neurological Disorders and Stroke Nervous System Physiology Neurologic Deficit Outcome Outcome Measure Parents Paresis Phase Physical Function Physical Rehabilitation Play Population Property Psychological reinforcement Psychometrics Public Health Randomized Controlled Trials Recovery Rehabilitation therapy Reporting Reproducibility Research Risk Scientific Advances and Accomplishments Selection for Treatments Standardization Statistical Models Stroke Technology Testing Time Toddler Toy United States National Institutes of Health Upper Extremity Walking Work age group arm arm movement base burden of illness clinical practice clinically relevant cohort constraint induced movement therapy cost data sharing disability dosage evidence base exercise intensity feeding follow-up grasp hemiparesis hemiparetic stroke improved indexing individualized medicine innovation longitudinal dataset motor impairment neurological rehabilitation novel peer perinatal ischemic stroke personalized medicine phase III trial physically handicapped prospective rehabilitation research remote assessment response skills tool treatment effect treatment response treatment strategy virtual assessment

项目摘要

The overall goal of this proposal is to develop and advance behavioral assessment methods (BAM) to measure spontaneous reach and grasp in infants and toddlers with and without hemiparetic cerebral palsy. Reach and grasp are critical to promoting healthy development and active engagement with the environment. This proposal focuses on the key period from 8 – 36 months of age when infants rapidly develop upper extremity skills, mobility, cognition, and language; and when hemiparesis-specific treatments, such as constraint-induced movement therapy, can be started. BAM will advance scientific knowledge about typical movements of the arms and hands as well as altered movements in children with hemiparetic cerebral palsy. This will yield a standardized, objective metric that quantifies the distance between impaired and typical development and will expand the precise measurement of treatment-induced recovery. This project includes prospective longitudinal data obtained from typically developing infants and toddlers and leverages video-sharing and support from StrokeNet’s Phase III randomized controlled trial of constraint-induced movement therapy. In AIM 1 we will develop the BAM Index using reach and grasp behaviors in 80 typically developing infants/toddlers and 240 infants/toddlers with perinatal arterial ischemic stroke and hemiparetic cerebral palsy. Videos will be coded for spontaneous reach and grasp frequency, duration, and exploratory behaviors with a common set of objects. Multiple statistical models will be employed to develop four standardized BAM Indices. In AIM 2 we will (a) evaluate the changes of four BAM Indices with 1040 longitudinal videos from the cohorts and (b) establish psychometric properties of the BAM Indices using: the Pediatric Stroke Outcome Measure (Neurological deficit and function); Gross Motor Function Measure-66 (Gross Motor), Bayley Scales of Infant and Toddler Development 4th edition (Fine Motor, Gross Motor, Language, and Cognition subscales), mini- and Assisting Hand Assessment (paretic hand); parent-reported outcome measures (Infant Motor Activity Log, MacArthur-Bates Communicative Developmental Inventories); and a combined clinical/parent outcome measure (Emerging Behaviors Scale). This project has the potential to advance pediatric rehabilitation research by affording a novel, reliable, precise, and sensitive measure of reach and grasp – applicable to hundreds of thousands of children with infant stroke and hemiparetic cerebral palsy. Furthermore, the novel use of data sharing and video coding are imperative for scientific reproducibility, reduction in cost, and will support the ability to improve health and physical function in infants and toddlers with cerebral palsy and other physical disabilities.

该提案的总体目标是开发和推进行为评估方法（BAM）测量患有或不患有偏瘫脑瘫的婴儿和幼儿的自发伸手和抓握能力。触及和掌握对于促进健康发展和积极参与环境至关重要。本方案针对婴儿上肢快速发育的8-36个月关键时期技能、活动能力、认知和语言；以及针对偏瘫的治疗，例如约束诱导可以开始运动疗法，BAM 将增进有关手臂典型运动的科学知识。以及偏瘫脑瘫儿童的手部和动作改变。标准化、客观的指标，量化受损发育和典型发育之间的距离以及意愿扩大治疗引起的恢复的精确测量该项目包括前瞻性纵向。从典型发育的婴儿和幼儿获得的数据，并利用视频共享和支持 StrokeNet 的约束诱导运动疗法的 III 期随机对照试验。在 AIM 1 中，我们将使用 80 个典型开发中的触及和掌握行为来开发 BAM 指数婴儿/幼儿和 240 名患有围产期动脉缺血性中风和偏瘫脑瘫的婴儿/幼儿。视频将针对自发到达和掌握频率、持续时间和探索行为进行编码将采用多种统计模型来开发四个标准化 BAM 指数。在 AIM 2 中，我们将 (a) 使用 1040 个纵向视频评估四个 BAM 指数的变化使用以下方法建立队列并 (b) BAM 指数的心理测量特性：儿科中风结果测量（神经缺陷和功能）；粗大运动功能测量 66（粗大运动），贝利量表婴幼儿发展第四版（精细运动、粗大运动、语言和认知分量表），迷你辅助手评估（瘫痪手）；家长报告的结果测量（婴儿运动活动日志，麦克阿瑟-贝茨沟通发展量表）和综合临床/家长结果测量（新兴行为量表）。该项目有潜力通过提供一种新颖、可靠、精确、灵敏的接触和抓握测量——适用于数十万有婴儿的儿童此外，数据共享和视频编码的新颖应用。对于科学可重复性、降低成本至关重要，并将支持改善健康和患有脑瘫和其他身体残疾的婴儿和幼儿的身体功能。