National Pediatric Rehabilitation Resource Center: Techniques Development

国家儿科康复资源中心：技术开发

基本信息

批准号：
10163242
负责人：
JILL C. HEATHCOCK
金额：
$ 14.15万
依托单位：
VIRGINIA POLYTECHNIC INST AND ST UNIV
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10163242
关键词：
Adherence Advanced Development Age Area Assessment tool Behavior Behavioral Biological Markers Biomedical Research Brain Categories Cerebral Palsy Child Childhood Clinical Clinical Trials Common Data Element Communities Data Reporting Documentation Environment Etiology Failure Frequencies Functional Magnetic Resonance Imaging Future Impairment Incentives Individual Infant Intervention Laboratories Measures Mentors Methods Modification Movement Near-Infrared Spectroscopy Neuronal Plasticity Ohio Outcome Measure Parents Patient Self-Report Pattern Pediatric Hospitals Performance Property Psychometrics Rehabilitation therapy Reporting Research Research Institute Research Personnel Resources Rest Science Scientist Scoring Method Senior Scientist Severities Sleep Specificity Standardization Techniques Technology Testing Time Treatment Protocols Universities Validation Video Games Virginia Work base clinical application clinical practice constraint induced movement therapy data standards dosage kinematics neuroimaging novel novel strategies off-label use primary outcome rehabilitation research robotic device secondary outcome skills technique development technology development tool wearable device

项目摘要

Project Summary (Techniques Development) The National Pediatric Rehabilitation Resource Center (PedRehab Ctr) will engage in development of techniques we consider highly promising, responsive to critical gaps in methods or technology in the field, and potentially multi-purpose in their application. Specifically, the areas we propose to pursue have application for both research and clinical practice. Pediatric rehabilitation research would benefit immensely from more sensitive, valid, and reliable approaches to measuring the emergence of new skills and their use in everyday function. Many tools in the new Common Data Elements (CDEs) for Cerebral Palsy were developed initially for typically developing children; others apply to only limited age ranges but often are used “off label;” and some designated as “exploratory” or “highly promising” lack confirmation (and likely further refinement) of their psychometric properties. Another major problem in pediatric rehabilitation trials has been the failure to measure Fidelity of Treatment (i.e., adherence to intended treatment protocols). Our PedRehab Ctr scientists have been active in developing and validating novel assessment tools from sophisticated kinematics to parent report tools; creating first ever Fidelity of Treatment tools for pediatric Constraint-Induced Movement Therapy and Bimanual treatment; and exploring the incorporation of various neuroimaging approaches to document treatment-induced neuroplasticity. Our specific aims for Techniques Development are: 1. To obtain confirmatory documentation of assessment methods for function, skill, and behaviors that go across laboratory and real-world environments. This includes use of kinematics and video-, game-, robotic-, and wearable-devices to supplement traditional standardized tests and systematic methods for establishing clinically meaningful thresholds for gain and losses; 2. To standardize modifications and summary scoring methods of currently used tools to allow for greater specificity and for use with children who vary widely in age, severity, and etiologies of neuromotor impairments; 3. To advance the development of Fidelity of Treatment measures to provide much-needed documentation of the actual delivery of rehabilitation interventions; and 4. To explore novel neuroimaging strategies for use as individual biomarkers and as valid, reliable indicators of treatment-induced neuroplasticity.

项目摘要（技术开发）国家儿科康复资源中心（Pedrehab CTR）将参与技术的发展我们认为高度有希望在其应用中多功能。具体而言，我们建议购买的领域都有两项研究的申请和临床实践。小儿康复研究将从更敏感，有效和可靠的方法来衡量新技能的出现及其在每天功能中的使用。许多工具最初开发了用于脑瘫的新的常见数据元素（CDE）通常用于开发孩子们;其他人仅适用于有限的年龄范围，但经常使用“关闭标签”；有些被指定为 “探索性”或“高度前景”缺乏对其心理测量学的确认（可能进一步完善）特性。小儿康复试验中的另一个主要问题是未能衡量治疗（即遵守预期的治疗方案）。我们的PEDREAB CTR科学家一直活跃从复杂的运动学到父母报告工具开发和验证新颖的评估工具；创建小儿约束诱导的运动疗法和双人治疗的治疗工具有史以来第一个保真度；并探索各种神经影像学方法的结合，以记录治疗诱导的神经可塑性。我们对技术开发的具体目标是： 1。获取有关运行功能，技能和行为的评估方法的确认文档跨实验室和现实世界环境。这包括使用运动学和视频，游戏 - 机器人和可穿戴设备，以补充传统的标准化测试和系统的方法建立临床上有意义的阈值，以获得收益和损失； 2。标准化修改和当前使用工具的摘要评分方法以允许更大特异性和与神经运动年龄，严重性和病因的儿童一起使用损害； 3。提高治疗措施的忠诚度以提供急需的实际交付康复干预措施的文件；和 4。探索用作单个生物标志物的新型神经影像学策略，并作为有效，可靠治疗引起的神经可塑性的指标。