FASEB Science Research Conference: Protein Kinases and Protein Phosphorylation

FASEB 科学研究会议：蛋白激酶和蛋白磷酸化

基本信息

批准号：
10464756
负责人：
Alex Toker
金额：
$ 0.35万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10464756
关键词：
Area Biochemical Biochemistry Biological Process Biology Canada Career Mobility Cellular biology Chemicals Clinical Collaborations Communication Data Development Diabetes Mellitus Diagnosis Discipline Disease Disease model Drug Industry Drug Targeting Educational workshop Event FDA approved Faculty Fertilization Fostering Funding Future Goals Growth and Development function Health Human Inflammation Inflammatory Island Knowledge Lighting Link Malignant Neoplasms Mediating Medicine Mentors Metabolic Diseases Metabolic syndrome Methodology Methods Mining Molecular Normal Cell Nova Scotia Oncology Phosphoric Monoester Hydrolases Phosphorylation Phosphotransferases Play Prevention Principal Investigator Process Protein Engineering Protein Kinase Protein Kinase Protein Phosphorylation Protein phosphatase Proteome Reporting Research Research Personnel Role Science Scientist Senior Scientist Signal Transduction Site Structure Structure-Activity Relationship Students System Systems Biology Technology Time Translational Research Underrepresented Minority Underrepresented Populations Woman career career development forging frontier human disease improved in vivo Model innovation insight interest kinase inhibitor meetings minority scientist multidisciplinary next generation novel novel anticancer drug novel therapeutics posters programs recruit social structural biology summer research symposium therapeutic development therapeutic target

项目摘要

Program Director/Principal Investigator (Last, First, Middle): Toker, A./Bennett, A. Protein phosphorylation is vitally important in the molecular communications that control cellular state and activity. It is a dynamic process mediated by kinases and phosphatases that are precisely regulated in normal cells, and deregulated in many human diseases, including diabetes, inflammatory disease and cancer. The study of the protein phosphorylation machinery and its function in signaling systems is a robustly active area of research that has driven methodological and conceptual advances and is increasingly contributing to the development of therapeutic options. Protein kinases are frequently deregulated in cancer, and they have been the focus of intense recent interest by the pharmaceutical industry. Indeed, most new cancer drugs approved by the FDA in the last several years target kinases, and there are hundreds of new kinase inhibitors under development. This strong clinical connection provides an exciting link with translational science. In this application, we request funds to support attendance of trainees, junior faculty and traditionally underrepresented groups at the 2022 FASEB Summer Research conference on Protein Kinases and Protein Phosphorylation. This biennial conference started in 1983, and is an important interdisciplinary gathering that brings together scientists with diverse expertise to advance understanding of the biochemical mechanisms and fundamental principles of phosphorylation events – a focus that distinguishes this meeting from others that deal with signaling networks and systems approaches. This FASEB meeting has been, and continues to be, a primary venue for the announcement of breakthroughs in the field, and has a long-standing goal to enhance, and disseminate, knowledge that will lead to improved therapies to target aberrant kinase activity, and protein phosphorylation, in human disease. The 2022 FASEB Science Research Conference on Protein Kinases and Protein Phosphorylation aims to highlight recent, cutting-edge findings in the field of protein phosphorylation, to bring together structural biology, biochemistry, systems biology, chemical biology, protein engineering, and medicine. This will promote cross-fertilization among these normally separate disciplines to stimulate new lines of research, as well as to enhance communication, collaboration, career advancement for the diverse scientists in the field. The ultimate goal is to advance the field to obtain better understandings of the molecular mechanisms that regulate important biological processes and facilitate the identification of critical targets for the diagnosis, prevention, treatment, and cure of human diseases. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page

项目总监/首席研究员（最后，第一，中间）：Toker，A./Bennett，a。蛋白质磷酸化在控制细胞态和活性。细胞，在许多人类疾病，含糖尿病，炎症疾病和癌症中受到管制。蛋白质富集机械及其在信号系统中的功能是一个强大的活动区域促进了方法论和概念进步的研究，并越来越多地为您做出贡献开发治疗选择。确实，大多数新的癌症药物都批准了制药行业的最近兴趣。过去几年的FDA可以接受激酶，以及数百种新的激酶抑制剂这种强大的临床连接为Translation提供了令人兴奋的。在此申请中，我们要求资金支持受训者，初级教师和传统上的出勤在2022年FaseB夏季研究会议上，代表性不足的蛋白质激酶和蛋白质研究会议 Phoss Biennial会议始于1983年，这是一个重要的跨学科聚会。汇集了具有多种专业知识的科学家，以促进对生化机制和磷酸化事件的基本原理 - 将这次会议与其他交易的会议区分开来的重点通过信号网络和系统方法。在该领域宣布突破的场所，并具有长期目标来增强目标传播的知识将导致改善靶向异常激酶活性的疗法和百叶窗磷酸化，人类疾病。蛋白质磷酸化的目的是突出蛋白质磷酸化领域的最新尖端发现。将结构生物学，生物化学，系统生物学，化学生物学，蛋白质工程和医学。研究，以增强沟通，协作，多元化科学家的职业发展在现场。规则的重要生物过程并促进诊断关键靶标的识别预防，治疗和治愈人类疾病。 OMB No. 0925-0001/0002（修订版01/18通过03/31/2020批准）页面延续格式页面