Translational Vision Science Research at Oregon Health & Science University

俄勒冈健康中心的转化视觉科学研究

• 批准号: 10463674
• 负责人: Yali Jia
• 金额: $ 15.61万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10463674
• 关键词: Health Sciences; Oregon; Research; Universities; vision science; Health Sciences; Oregon; Research; Universities; vision science

PROJECT SUMMARY The premise of this proposal is that training the next generation of vision scientists in translation of basic science research to clinical and public health interventions will be critical toward advancing the field. Basic scientific and technological advances are occurring at an unprecedented pace. However, our observation has been that ophthalmologists often lack the background to understand how recent basic and clinical research findings may be applied to their practices, and visual scientists often lack adequate perspective to identify gaps in clinical knowledge to guide their research. This application proposes to renew a successful T32 translational vision research training program for students in pre-doctoral training programs in basic or applied science, or postdoctoral fellows at Oregon Health & Science University (OHSU). The overall goal is to prepare individuals for successful academic careers in vision science research through didactic education and intensive mentored research experience in a multidisciplinary environment. The vision research and training environment at OHSU is highly collaborative and interdisciplinary, with strong programmatic support in translation of research from bench to bedside in areas such as gene therapy, molecular genetics, drug development, clinical trials, ophthalmic imaging, and biomedical informatics. The university has top educational programs in clinical ophthalmology and basic visual science, and is consistently ranked in the top 10 nationally in NEI-supported research. This program fills an important gap in education because OHSU is one of the few major academic medical centers in the Pacific Northwest, yet there are no other programs to support didactic training in visual science research here. We will continue to leverage the existing infrastructure at OHSU to allow more pre- doctoral and post-doctoral trainees to benefit from and contribute toward this research and educational environment. Since 2013, we have supported 13 trainees (including 2 under-represented minorities and 3 women) who have published 60 peer-reviewed papers with their mentors in leading journals. Specifically, we propose to continue this T32 program for 3 pre-doctoral and 1 post-doctoral trainee, which will be integrated with ongoing research and existing OHSU graduate programs in basic science. Training consists of six key components: (1) research projects with mentors and collaborators, (2) a didactic course covering fundamentals of basic, clinical, and translational vision science, (3) twice-monthly vision research seminars for discussion of ongoing research by trainees and faculty, along with weekly half-day teaching sessions, (4) institution-wide education and career development activities, (5) a grant mentorship program to teach and support trainees as they apply for their own, independent funding and (6) training in responsible conduct of research. We believe this program will continue to provide a clinical perspective to trainees with existing backgrounds in basic science. OHSU is a setting where rigorous training in basic and clinical research through this T32 program will provide a generation of young researchers with the tools to optimize translational vision research.

项目摘要 该提议的前提是，培训下一代愿景科学家的基础翻译 临床和公共卫生干预措施的科学研究对于推进该领域至关重要。基本的 科学和技术进步以空前的速度发生。但是，我们的观察有 一直以来，眼科医生通常缺乏了解最近基础和临床研究的背景 发现可能应用于他们的实践，视觉科学家通常缺乏足够的观点来识别差距 根据临床知识指导他们的研究。该应用程序建议续签成功的T32翻译 在基础科学或应用科学的博士前培训计划中针对学生的视觉研究培训计划，或 俄勒冈州健康与科学大学（OHSU）的博士后研究员。总体目标是为个人做好准备 通过教学教育和密集的指导，为了成功地在视力科学研究中进行学术职业 多学科环境中的研究经验。 OHSU的视觉研究和培训环境 是高度协作和跨学科的，在翻译研究中的强烈程序化支持 基因治疗，分子遗传学，药物发育，临床试验等领域的长凳到床边 眼科成像和生物医学信息学。该大学拥有临床领域的顶级教育计划 眼科和基本视觉科学，并始终在Nei支持的全国前十名中排名 研究。该计划填补了教育的重要差距，因为OHSU是为数不多的主要学术之一 西北太平洋的医疗中心，但没有其他计划可以支持视觉上的教学培训 科学研究在这里。我们将继续利用OHSU的现有基础设施来允许更多的预先 博士和博士后学员将受益并为这项研究和教育做出贡献 环境。自2013年以来，我们支持13名学员（包括2名代表不足的少数民族和3名 妇女）在领先的期刊上发表了与他们的导师一起发表了60篇经过同行评审的论文。具体来说，我们 建议继续为3个博士后和1名博士后学员的T32计划，该计划将被整合 通过正在进行的研究和现有的OHSU基础科学研究生课程。培训由六个钥匙组成 组件：（1）与导师和合作者一起研究项目，（2）涵盖基本面的教学课程 基础，临床和转化视觉科学，（3）每月两次远见研究研讨会讨论 受训者和教师正在进行的研究，以及每周半天的教学课程，（4）机构范围内 教育和职业发展活动，（5）授予指导计划，以教学和支持受训者为 他们申请自己的独立资金和（6）负责任的研究培训。我们相信 该计划将继续为具有基本背景的受训者提供临床视角 科学。 OHSU是通过此T32计划进行基础和临床研究的严格培训的环境 为一代年轻的研究人员提供优化翻译视觉研究的工具。