Visual Perception in Visual Snow Syndrome

视雪综合症的视觉感知

• 批准号: 10463429
• 负责人: Samantha A Montoya
• 金额: $ 3.33万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-29 至 2025-08-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10463429
• 关键词: Address; Afterimage; Automobile Driving; Behavioral; Brain; Clinical; Contrast Sensitivity; Detection; Diagnosis; Disease; Environment; Exhibits; Frequencies; Functional Magnetic Resonance Imaging; Future; Human; Image; Knowledge; Life; Magnetic Resonance; Masks; Measurement; Measures; Migraine; Neurologic; Participant; Patients; Perception; Performance; Persons; Pharmacologic Substance; Photic Stimulation; Photophobia; Prevalence; Process; Psychophysics; Quality of life; Reading; Research; Resolution; Science; Self-Help Devices; Sensory; Series; Signal Transduction; Stimulus; Symptoms; Syndrome; Television; Testing; Time; Tinnitus; Training; Vision; Vision Disorders; Visual; Visual Fields; Visual Perception; Visual Psychophysics; Visual system structure; Work; associated symptom; base; career; common symptom; comorbidity; effective therapy; experience; experimental study; improved; luminance; neuroimaging; neuromechanism; novel; relating to nervous system; response; vision science; visual performance; visual process; visual processing; visual stimulus

Project Summary/Abstract Visual Snow Syndrome (VSS) is a serious but poorly understood visual disorder characterized by the persistent perception of specks flickering across the entire visual field, akin to television snow. VSS has an estimated prevalence of 1.4-3.3% and is often accompanied by additional symptoms such as prominent afterimages (palinopsia), poor night vision, entoptic phenomena, and photophobia (light sensitivity). These symptoms make tasks like reading and driving particularly difficult. While previous research has focused on identifying the common symptoms and comorbidities, effective treatments have not been identified, the mechanisms underlying the disorder are still unknown, and quantitative assessments of visual perception remain sparse. The proposed research seeks to address these knowledge gaps by measuring differences in visual performance and associated neural processing with a series of well-established psychophysical and imaging paradigms. To provide quantitative measures of perception and visual processing in VSS, we will assess (1) contrast sensitivity, (2) spatial context, and (3) temporal context perception in people with VSS compared to normally sighted controls through a series of fundamental psychophysical and high field (7T) functional magnetic resonance imaging (fMRI) experiments. These experiments will help us understand how people with VSS perceive and process contrast, which is an important measure of visual function that is related to performance on every-day visual tasks. Additionally, the proposed research will address how both spatial and temporal context are altered in VSS—previous but sparse research suggests that both spatial and temporal context may be altered in VSS, but further evidence with both larger numbers of participants and robust measures of neural activity are required to investigate potential differences in visual context processing. Critically, we will also provide high resolution 7T fMRI measures of cortical responses during visual tasks to investigate potential differences in gain control throughout the visual system. The proposed assessment of visual perception and accompanying measurements of neural processing in VSS are necessary to better characterize this disorder, and will help formulate hypotheses about mechanisms underlying VSS.

项目摘要/摘要 视觉雪综合症（VSS）是一种严重但糟糕的联盟视觉障碍，其特征是持续 对整个视野的斑点的感知，类似于电视雪。 患病率为1.4-3.3％，通常伴随着其他症状，例如突出的余数 （palinopsia），夜视不良，恩特型现象和恐惧症（光敏感性） 诸如阅读和驾驶的任务尤其是difficalt。 常见症状和合并症，尚未确定有效治疗，其基础机制 该疾病仍然未知，视觉感知的定量评估仍然很少 研究旨在通过衡量视觉性能的差异和 相关的神经处理与一系列完善的心理物理和成像范式 提供VSS中的感知和视觉处理的定量度量，我们将评估（1）对比灵敏度， （2）空间上下文，（3）与正常视力对照相比，VSS患者的时间上下文感知 通过一系列基本心理物理和高场（7T）功能磁共振成像 （fMRI）实验。 对比，这是视觉功能的重要衡量，与每天视觉的性能有关 任务。 VSS-备受抗衡但稀疏的研究表明，VSS可能会改变空间和时间环境，但 需要大量参与者的进一步证据，并且需要对神经活动的强大度量 研究视觉上下文处理中的潜在差异。 在视觉任务期间，FMRI的皮质反应测量值研究增益控制中的潜在差异 在整个视觉系统中。 VSS中的神经处理是必要的，以更好地表征这种疾病，并有助于提出假设 关于基础VSS的机制。