Towards a unified framework for dopamine signaling in the striatum

建立纹状体多巴胺信号传导的统一框架

基本信息

批准号：
10460152
负责人：
JOHN ASSAD
金额：
$ 375.75万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10460152
关键词：
Affect Anatomy Animal Behavior Animals Basal Ganglia Behavior Behavioral Biological Brain Cells Code Collaborations Communities Computer Models Corpus striatum structure Cues Data Data Science Dopamine Dorsal Elements Environment Exploratory Behavior Failure Future Goals Head Human Knowledge Laboratories Learning Link Midbrain structure Modeling Modification Monitor Motor Movement Mus Nature Neurons Outcome Phase Population Probability Protocols documentation Psychological reinforcement Recording of previous events Research Resources Rewards Sensory Signal Transduction Substantia nigra structure System Techniques Time Training Update Ventral Striatum Ventral Tegmental Area Work design dopaminergic neuron expectation experience experimental study ganglion cell goal oriented behavior instrumentation novel pars compacta prevent response theories

项目摘要

Project abstract Animals, including humans, interact with their environment via self-generated and continuous actions that enable them to explore and subsequently experience the positive and negative consequences of their actions. As a result of their interactions with the environment, animals alter their future behavior, typically in a manner that maximizes positive and minimizes negative outcomes. Furthermore, how an animal interacts with its environment and the actions that it chooses depend on its current environment, its past experience in that environment, as well as its internal state. Thus, the actions taken by an animal are dynamic and evolving, as necessary for behavioral adaptation. It is thought that both the execution of actions, in particular goal-oriented actions, and the modification of future behavior in response to the outcome of actions, depend on evolutionarily old parts of the brain called the basal ganglia. Within the basal ganglia, cells that produce dopamine have a profound influence on behavior, including human behavior, and their activity appears to encode for features of the environment and animal experience that are important for directing goal-oriented behavior. Here we bring together a team of experimental and computational neurobiologists to understand how these dopamine- producing cells modulate behavior and basal ganglia circuitry. We will use unifying theories and models to integrate information acquired over many classes of behavior. Completing the proposed work, including the technical advances and biological discoveries, will provide a platform for future analyses of related circuitry and behaviors in many species, including humans.

项目摘要包括人类在内的动物通过自我生成和连续的行动与环境互动使他们能够探索并随后体验其行为的积极和负面后果。由于它们与环境的互动，动物通常以某种方式改变其未来行为这可以最大化积极并最大程度地减少负面结果。此外，动物如何与动物相互作用环境及其选择的行动取决于其当前环境，过去的经验环境及其内部状态。因此，动物采取的动作是动态的和不断发展的，行为适应所必需的。据认为，两种动作的执行，尤其是面向目标的行动，以及对行动结果的响应对未来行为的修改，取决于进化大脑的旧部分称为基底神经节。在基底神经节内，产生多巴胺的细胞具有对行为的深刻影响，包括人类行为及其活动似乎编码为对于指导面向目标的行为很重要的环境和动物体验。我们带来一组实验和计算神经生物学家团队，以了解这些多巴胺如何产生细胞调节行为和基础神经节回路。我们将使用统一的理论和模型来整合在许多类别的行为上获得的信息。完成拟议的工作，包括技术进步和生物学发现将为将来分析相关电路和包括人类在内的许多物种中的行为。