Administrative Core

行政核心

基本信息

批准号：
10458537
负责人：
Robert P Schleimer
金额：
$ 11.38万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10458537
关键词：
Administrator Asthma Attention Award Biological Assay Biometry Bronchiectasis Budgets Chicago Clinical Collaborations Communication Communities Data Data Set Discipline Doctor of Philosophy Ensure Environment Epidemiologist Epidemiology Funding Future Goals Government Agencies Grant Human Resources Hypersensitivity Immunologist Immunology Individual Institution Interdisciplinary Study Internet Link Lung diseases Maintenance Manuscripts Medical Students Molecular Nasal Polyps Natural History Office of Administrative Management Otolaryngologist Outcome Pathogenesis Patients Persons Phenotype Play Postdoctoral Fellow Preparation Progress Reports Publications Recording of previous events Reporting Research Research Personnel Role Scholarship Services Severities Site Symptoms System Teleconferences Training Translating United States National Institutes of Health Woman Work base chronic rhinosinusitis clinical phenotype comorbidity data handling data sharing disease heterogeneity doctoral student innovation meetings member men programs promoter synergism web site

项目摘要

ABSTRACT The Chronic Rhinosinusitis Integrative Studies Program 2 (CRISP2) is an integrated program of epidemiologists, otolaryngologists, allergists and immunologists in which highly collaborative studies are proposed to better understand the molecular and cellular mechanisms of disease heterogeneity and how these mechanisms translate into clinical phenotypes, natural history and long term outcomes. The program focuses particular attention to CRS without nasal polyps (CRSsNP), a highly prevalent and yet obscure phenotype from the standpoint of our current understanding. Another focus of CRISP2 is to critically evaluate the mechanisms and consequences of comorbid conditions in which patients have both CRS and lung disease such as asthma or bronchiectasis. Yet another theme is to make inroads in our understanding of why women are more significantly impacted by CRS than men. In order to achieve these goals, the investigators that comprise the CRISP2 study team have innovated new assays and approaches to cutting edge studies of pathogenesis and epidemiology and, most importantly, have merged these two disciplines to relate mechanisms to symptoms, severity, history and outcomes of CRS. The Administrative Core (Core A) has as its main functions the goals of providing administrative support for the vigorous integrative efforts of the program, facilitating communication and data sharing, catalyzing publications and reporting of the findings of the work, ensuring that the Chronic Rhinosinusitis Integrative Research Program-2 (CRISP2) promotes an effective training function and organizing the advisory board and the regular meetings of the CRISP2 participating centers and investigators. Core A is also responsible for the preparation of progress reports for the program and overseeing regulatory compliance with various institutional and governmental agencies. Core A will play a central role in promoting synergy and advanced collaborative interactions in the program. We have organized these and other functions into the following specific aims: 1.) To provide central administrative services for CRISP2, including oversight of funds distribution, managing the administrative office, facilitating changes that occur in budget, personnel or scientific direction, overseeing preparation of progress reports and assurance of appropriate compliance with directives from the NIH, NU, UC, G/JHU and local, state and federal agencies. The administrative team is Dr. Schleimer (PI), Ms. Valarie Thomas and Ms. Seletta Nichols (administrators) and Dr. Alfred Rademaker (biostatistician). 2.) To facilitate communications in CRISP2 and organize an advisory board. CRISP2 will have four quarterly meetings each year and will maintain an internet-based cloud communications system. 3.) To disseminate discoveries made by CRISP2. Core A will facilitate manuscript preparation and maintenance of a website. 4.) To encourage training. Core A will support an ongoing grant program for young scholars. 5.) To promote interdisciplinary research. Core A will facilitate interactions of the disciplines and individual investigators that are involved in CRISP2.

摘要慢性鼻腔炎综合研究计划2（CRISP2）是一个综合程序流行病学家，耳鼻喉科医生，过敏症医生和免疫学家，其中高度协作研究是提议更好地了解疾病异质性的分子和细胞机制，以及如何机制转化为临床表型，自然历史和长期结局。该计划的重点特别注意没有鼻息（CRSSNP）的CR，这是一种高度普遍但晦涩的表型我们当前理解的立场。 CRISP2的另一个重点是批判性评估机制以及患者患有CRS和肺部疾病（例如哮喘）的合并症的后果或支气管扩张。另一个主题是使我们了解女性为什么更多受CRS的影响比男性受到重大影响。为了实现这些目标，构成的调查人员 CRISP2研究团队已经创新了新的分析和方法，以进行发病机理的最先进研究流行病学，最重要的是，已经合并了这两个学科，以将机制与症状相关联， CRS的严重性，历史和结果。行政核心（核心A）的主要功能是提供行政支持的目标为了促进该计划的综合努力，促进沟通和数据共享，催化出版和报告作品发现，确保慢性鼻鼻涕综合性 Research Program-2（CRISP2）促进有效的培训功能并组织咨询委员会，并 CRISP2参与中心和调查人员的定期会议。核心A还负责准备该计划的进度报告并监督对各种机构的监管依从性和政府机构。核心A将在促进协同和高级协作方面发挥核心作用程序中的交互。我们已经将这些功能组织为以下特定目的：1。）为CRISP2提供中央行政服务，包括对资金分配的监督，管理行政办公室，促进预算，人员或科学方向发生的变化，监督准备进度报告并确保适当遵守NIH，NU，UC， G/JHU和地方，州和联邦机构。行政团队是Schleimer博士（PI），Valarie Thomas女士以及Seletta Nichols女士（管理员）和Alfred Rademaker博士（生物统计学家）。 2.）促进 CRISP2的通信并组织了一个顾问委员会。 CRISP2每个季度会议都会一年，将维护基于Internet的云通信系统。 3.）传播由 crisp2。核心A将促进网站的手稿准备和维护。 4.）鼓励培训。核心A将支持正在进行的年轻学者的赠款计划。 5.）促进跨学科研究。核心A将促进CRISP2涉及的学科和个人调查员的互动。