Limited Competition for Continuation of the MAPP-RN DCC

继续 MAPP-RN DCC 的有限竞争

• 批准号: 10464136
• 负责人: J Richard Landis
• 金额: $ 50万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-09 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10464136
• 关键词: Administrative Supplement; Algorithms; Biological Markers; Biological Specimen Banks; Budgets; Case Report Form; Case Study; Clinical; Clinical Data; Cluster Analysis; Cohort Studies; Collaborations; Colorado; Consensus; Data; Deposition; Documentation; Educational Materials; Educational workshop; Engineering; Epidemiology; Funding; General Population; Grant; Investigation; Link; Longitudinal Studies; MRI Scans; Magnetic Resonance Imaging; Measures; Metadata; Methods; National Institute of Diabetes and Digestive and Kidney Diseases; Online Systems; Outcome; Patients; Pattern; Pelvic Pain; Pennsylvania; Phase; Phenotype; Preparation; Procedures; Process; Research; Research Design; Research Personnel; Resources; Schedule; Services; Severities; Specimen; Subgroup; Symptoms; Universities; Visit; chronic pelvic pain; comparative; data curation; data dictionary; data harmonization; data repository; data resource; data visualization; design; improved; interdisciplinary approach; interest; longitudinal analysis; medical schools; neuroimaging; programs; prototype; repository; response; urinary; web site

Project Summary This proposal for an Administrative Supplement to the U24 grant for the Continuation of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Data Coordinating Core (DCC) is being submitted by the DCC for the MAPP Research Network (MAPP-RN) at the University of Pennsylvania Perelman School of Medicine. The DCC team will provide additional services beyond those currently funded as the DCC for the MAPP Research Network, in support of new Specific Aims 1-5 during the current budget year 14 (BY14). The clinical data, documentation and descriptions of the biospecimen resources from the MAPP I EPS and MAPP II SPS will be made accessible for “public facing” exploration via a re-engineered MAPP website (Specific Aim 1), together with a totally new MAPP DataView toolkit (Specific Aim 3) designed for data visualization and for the conduct of comparative analyses between, and within, the extensive EPS and SPS cohort data, as well as to conduct advanced analyses within selected subgroups assembled by aggregating aligned data across both of these two cohort studies. In addition to implementing final data curation and harmonization across the EPS and SPS cohort data, the DCC will prepare extensive documentation for simultaneous posting on the new MAPP website and for deposit to the NIDDK Repository (Specific Aim 2). Furthermore, the DCC will prepare workshop materials and host MAPP DataView workshops, promoting MAPP data use for new research investigations (Specific Aim 4). Educational materials designed for investigators and research teams to maximize the utility of these data resources and to implement specialized statistical procedures (consensus clustering for baseline subgroup discovery, quantifying clinically meaningful change utilizing Global Response Assessment (GRA) scores and levels of symptom change, longitudinal functional clustering for outcome subgroup discovery) applied to MAPP II SPS data will be emphasized. In particular, the DCC will prepare longitudinal analyses using the Global Response Assessment (GRA), Pelvic Pain Severity (PPS) and Urinary Symptoms Severity (USS) profiles available within the MAPP II SPS to identify factors associated with simultaneous improvement in both PPS and USS symptom profiles, in contrast to patients that improve only in PPS, only in USS, or in neither of PPS or USS (Specific Aim 5).

项目摘要 该提案向U24赠款提供了行政补充，以继续 慢性骨盆疼痛研究（MAPP）研究网络数据的多学科方法 DCC正在为MAPP研究网络（MAPP-RN）提交协调核心（DCC） 宾夕法尼亚大学佩雷​​曼医学院。 DCC团队将提供其他 超越当前作为MAPP研究网络DCC资助的服务，以支持新 当前预算14年（BY14）的特定目标1-5。临床数据，文档和 将从MAPP I EPS和MAPP II SPS的Biospecipimen资源描述可访问 通过重新设计的MAPP网站（特定的AIM 1）进行“公开面对”探索，以及一个全新的 MAPP DATAVIEW TOOLKIT（特定目标3）旨在数据可视化和进行比较 在广泛的EPS和SPS队列数据之间进行分析，并进行高级 通过在这两个中汇总对齐数据组装的选定子组中的分析 队列研究。除了在EPS和SPS上实施最终数据策划和协调 队列数据，DCC将准备大量文档，以简单发布新的MAPP 网站并存入NIDDK存储库（特定目标2）。此外，DCC将准备 研讨会材料和主持人MAPP DATAVIEW研讨会，促进MAPP数据使用进行新研究 调查（特定目标4）。为调查人员和研究团队设计的教育材料 最大化这些数据资源的效用并实施专业的统计程序 （基线亚组发现的共识聚类，量化利用临床上有意义的变化 全球反应评估（GRA）评分和症状变化水平，纵向功能 将强调应用于MAPP II SPS数据的结果亚组发现的聚类。在 特别是，DCC将使用全球响应评估（GRA），骨盆制备纵向分析 疼痛严重程度（PPS）和泌尿症状严重程度（USS）轮廓可用于MAPP II SPS 相比之下 对于仅在PPS，仅在US或PPS或USS中改进的患者（特定AIM 5）。

项目成果

Functional mixed effects clustering with application to longitudinal urologic chronic pelvic pain syndrome symptom data.

• DOI: 10.1080/01621459.2022.2066536
• 发表时间: 2022
• 期刊: Journal of the American Statistical Association
• 影响因子: 3.7

Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia.

• DOI: 10.1111/ner.13512
• 发表时间: 2023-07
• 期刊: Neuromodulation : journal of the International Neuromodulation Society
• 作者: Lim M;Kim DJ;Nascimento TD;Ichesco E;Kaplan C;Harris RE;DaSilva AF
• 通讯作者: DaSilva AF

Reliability and Validity of Pain and Urinary Symptom Severity Assessment in Urological Chronic Pelvic Pain: A MAPP Network Analysis.

• DOI: 10.1097/ju.0000000000002438
• 发表时间: 2022-06
• 期刊: JOURNAL OF UROLOGY
• 影响因子: 6.6
• 作者: Naliboff, Bruce D.;Locke, Kenneth, Jr.;Schrepf, Andrew D.;Griffith, James W.;Moldwin, Robert;Krieger, John N.;Rodriguez, Larissa V.;Clemens, J. Quentin;Lai, H. Henry;Sutcliffe, Siobhan;Taple, Bayley J.;Williams, David;Pontari, Michael A.;Mullins, Chris;Landis, J. Richard
• 通讯作者: Landis, J. Richard

Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network.

泌尿科慢性盆腔疼痛综合征发作及其影响：MAPP 网络中的定性分析。

• DOI: 10.1007/s00192-015-2652-6
• 发表时间: 2015
• 期刊: International urogynecology journal
• 影响因子: 1.8
• 作者: Sutcliffe,Siobhan;Bradley,CatherineS;Clemens,JamesQuentin;James,AimeeS;Konkle,KatyS;Kreder,KarlJ;Lai,HingHungHenry;Mackey,SeanC;Ashe-McNalley,CodyP;Rodriguez,LarissaV;Barrell,Edward;Hou,Xiaoling;Robinson,NancyA;Mullins
• 通讯作者: Mullins

Association of Longitudinal Changes in Symptoms and Urinary Biomarkers in Patients with Urological Chronic Pelvic Pain Syndrome: A MAPP Research Network Study.

• DOI: 10.1097/ju.0000000000001391
• 发表时间: 2021-03
• 期刊: The Journal of urology
• 作者: Roy R;Stephens AJ;Daisy C;Merritt L;Newcomb CW;Yang J;Dagher A;Curatolo A;Sachdev M;McNeish B;Landis R;van Bokhoven A;El-Hayek A;Froehlich J;Pontari MA;Zurakowski D;Lee RS;Moses MA
• 通讯作者: Moses MA