Investigating neighborhood-environment contributions to midlife risk for dementia

调查邻里环境对中年痴呆风险的影响

基本信息

批准号：
10457188
负责人：
Aaron Reuben
金额：
$ 6.93万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10457188
关键词：
Age Aging Air Pollution Amber Archives Birth Brain Brain Diseases Characteristics Clinical Cognitive aging Community Health Data Data Linkages Dementia Development Disadvantaged Disease Economic Conditions Educational process of instructing Educational workshop Elderly Ensure Environment Environmental Epidemiology Environmental Exposure Environmental Health Exposure to Fellowship Future Genetic Geroscience Goals Grain Grant Health Health Care Sector Health Psychology Health behavior Hypertension Individual Inflammation Intervention Investigation Leisures Life Link Longevity Longitudinal Studies Magnetic Resonance Imaging Measures Mediating Mentors Mentorship Methods Michigan Modeling Neighborhoods Nerve Degeneration Neurologic Neurotoxins New Zealand Organ Outcome Pathologic Patient Self-Report Phase Phenotype Physical activity Play Policies Population Prevention Psychosocial Assessment and Care Public Health Reporting Research Research Personnel Resources Risk Risk Factors Role Social Conditions Sports Structure Symptoms System Techniques Testing Time Training Training Activity Universities Work Writing age related aging brain base behavior change brain health career career preparation cognitive ability cognitive change cognitive function cognitive performance cognitive testing cohort data resource dementia risk disorder prevention evidence base follow-up good diet gray matter health disparity high risk improved infancy informant innovation insight member middle age modifiable risk neighborhood disadvantage neuroimaging neuropsychiatry novel prevent prospective psychosocial skills social social stressor sociodemographics socioeconomics stressor symposium white matter

项目摘要

PROJECT SUMMARY / ABSTRACT Older adults living in disadvantaged neighborhoods, marked by poor physical, social, and economic conditions, are at elevated risk for dementia regardless of their personal sociodemographic characteristics. It is not yet clear when in the lifespan such risk emerges or through which putative causal mechanisms, if it is indeed causal. The activities proposed in this application will fill key research gaps in environmental health and geroscience through first-ever longitudinal studies of neighborhood characteristics and brain aging in midlife, when it is still possible to intervene to prevent dementia. They will inform the identification of at-risk individuals and significantly advance the evidence base needed for potential neighborhood-level dementia interventions, which could leverage public resources outside the healthcare sector and operate without requiring individual behavior change. Proposed projects will integrate diverse geospatial neighborhood data (housed at Michigan State University) into the four-decade archives of the Dunedin Study of psychosocial health, development, and aging among a population-representative New Zealand-based cohort born in 1972 and followed to midlife. The Dunedin cohort is the only one in the world with fine-grained measures of brain integrity from infancy to midlife, with the latest assessment (age 45) including brain structural and functional antecedents of dementia. Studies will determine: (1) whether individuals living in disadvantaged neighborhoods demonstrate signs of accelerated brain aging by midlife; (2) if specific neighborhood characteristics are uniquely associated with midlife brain- health deficits; and (3) whether pro-degenerative health behaviors and conditions (e.g., low physical activity, hypertension, etc.) and are more common in disadvantaged settings and thus may act as causal meditators. The applicant’s career goal is to become a clinical neuropsychologist and independent academic researcher who conducts public health-oriented research on the degenerative consequences of environmental exposures in the hopes of identifying modifiable risk factors and unique interventions to lower the global burden of brain disease. This fellowship will leverage a multi-university training plan to significantly advance the applicant’s career by allowing him to: (1) enter a PI-role in the Dunedin Study; (2) gain additional training to advance his unique research goals, including in established and cutting-edge methods in geospatial analysis, neurotoxicant assessment, and premorbid modeling of brain aging and dementia; and (3) prepare for an innovative career bridging environmental health and psychology with job-readiness skills in teaching, mentoring, and grant writing and management. Mentored training will occur in psychiatric, geospatial, and environmental epidemiology labs at Duke, Michigan State, and Harvard, supplemented by coursework, workshops, and conferences. The fellowship will ensure the applicant's move to independence for a unique body of work investigating environmental contributions to pathological brain aging, with future steps involving additional data linkage and assessment in older and younger cohorts and at the next assessment phase of the Dunedin Study.

项目摘要 /摘要老年人生活在不利的社区，其身体，社会和经济状况不佳，无论其个人社会人口统计学特征如何，痴呆症的风险都高。还没有清楚这种风险何时出现，或者通过哪种假定的因果机制因果。本申请中提出的活动将填补环境健康方面的关键研究空白，通过对中年的邻里特征和大脑衰老的有史以来的首次纵向研究，当仍然可以干预以防止痴呆症时。他们将告知处于危险的人的身份并显着提高潜在邻里水平痴呆干预所需的证据基础，它可以利用医疗保健部门以外的公共资源并在不需要个人的情况下运营行为改变。拟议的项目将集成分歧地理空间邻里数据（位于密歇根州州立大学）进入了对心理健康，发展和在1972年出生的新西兰人口代表性的同类人群中的老化，随后到中年。这达尼丁队列是世界上唯一具有从婴儿期到中年的精细脑完整性度量的人，带有最新评估（45岁），包括痴呆症的大脑结构和功能前因。研究将确定：（1）生活在不利社区中的个人是否表现出加速的迹象中年的大脑衰老；（2）如果特定的邻里特征与中年大脑唯一相关健康缺陷；（3）促成降低的健康行为和条件是否（例如，体育活动低，高血压等），在不利的环境中更为常见，因此可能充当因果冥想者。申请人的职业目标是成为临床神经心理学家和独立学术研究员谁对环境暴露的退化后果进行了以公共卫生为导向的研究希望确定可修改的危险因素和独特的干预措施，以降低大脑的全球负担疾病。该奖学金将利用多元大学培训计划，以大大推动申请人的通过允许他的职业：（1）在但尼丁研究中输入pi-lole；（2）获得额外的培训以推动他的独特的研究目标，包括在地理空间分析中的既定和尖端方法中，神经毒性评估和脑衰老和痴呆症的病前建模；（3）为创新的职业做准备在教学，心理和授予方面具有工作准备技能，弥合环境健康和心理学写作和管理。指导培训将在精神病，地理空间和环境中进行密歇根州杜克大学和哈佛的流行病学实验室，并补充了课程，研讨会和会议。奖学金将确保申请人转向独立的独特工作调查对病理大脑衰老的环境贡献，未来步骤涉及其他数据在DUNEDIN研究的下一个评估阶段，在年龄较大和年轻的队列中的联系和评估。