Core D: Neuroimaging Core

核心 D：神经影像核心

• 批准号: 10454255
• 负责人: Bradley T Christian
• 金额: $ 432.65万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454255
• 关键词: Address; Adult; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer’s disease biomarker; Amyloid; Anatomy; Attenuated; Biological; Biological Markers; Brain; Brain region; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical; Communities; Data; Data Sources; Databases; Dementia; Diffusion Magnetic Resonance Imaging; Down Syndrome; Functional Magnetic Resonance Imaging; General Population; Genomics; Glucose; Goals; Image; Infarction; Infrastructure; Inherited; Investigation; Laboratories; Liquid substance; Magnetic Resonance Imaging; Measurement; Measures; Mind; Modality; Nerve Degeneration; Outcome; Outcome Measure; Pathologic; Pittsburgh Compound-B; Population; Positron-Emission Tomography; Process; Protocols documentation; Quality Control; Recovery; Research Personnel; Resolution; Resources; Rest; Risk Factors; Scanning; Site; Standardization; Statistical Data Interpretation; Study of magnetics; Symptoms; Techniques; Thick; White Matter Hyperintensity; Work; arterial spin labeling; base; blood oxygen level dependent; cerebrovascular; data access; design; fluorodeoxyglucose; fluorodeoxyglucose positron emission tomography; glucose metabolism; imaging modality; insight; interest; metabolic rate; neuroimaging; neuroimaging marker; performance site; precision medicine; primary outcome; tau Proteins; white matter

Neuroimaging Core Abstract The ABC-DS Neuroimaging Core, led by Drs. Adam Brickman and Brad Christian, will apply state-of-the art positron emission tomography (PET) and magnetic resonance imaging (MRI) neuroimaging techniques to quantitate amyloid, tau, and neurodegeneration (AT(N)) in Down syndrome (DS) according to current pathophysiological models of Alzheimer’s disease (AD) together with related cerebrovascular, microstructural, and functional biomarkers. The specific aims of the Neuroimaging Core are to: (1) oversee the harmonized acquisition of PET and MRI data at each of the 8 clinical performance sites; (2) quantitate primary outcome measures for each neuroimaging modality; (3) integrate the processed neuroimaging data into a ABC-DS database to support the proposed projects; and (4) provide curated primary outcome variables and raw neuroimaging data to the wider scientific community. The overall scanning protocols will follow those developed by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) for MRI (structural and functional) and PET (amyloid, tau, FDG). The outcome variables are derived by modality-specific analytic nodes, with each modality analyzed by a single laboratory with expertise in that neuroimaging biomarker. The Core will utilize NIA-sponsored resources that currently support ongoing large-scale AD neuroimaging initiatives (e.g. ADNI, Dominantly Inherited Alzheimer Network (DIAN)) to provide a fully developed data-access pipeline that encourages scientific investigation of neuroimaging biomarkers in DS.

神经影像学核心摘要 由Drs领导的ABC-DS神经成像核心。亚当·布里克曼（Adam Brickman）和布拉德·克里斯蒂安（Brad Christian）将采用最先进 正电子发射断层扫描（PET）和磁共振成像（MRI）神经影像学技术 根据电流定量淀粉样蛋白，tau和神经变性（at（n））（DS） 阿尔茨海默氏病（AD）的病理生理模型以及相关的脑血管，微结构， 和功能性生物标志物。神经成像核心的具体目的是：（1）监督协调的 在8个临床性能站点中的每个站点中的每个部位获取PET和MRI数据； （2）定量主要结果 每种神经影像模式的措施； （3）将处理后的神经成像数据集成到ABC-DS中 支持拟议项目的数据库； （4）提供精选的主要结果变量和原始 向更广泛的科学界的神经影像学数据。总体扫描协议将遵循开发的协议 由阿尔茨海默氏病神经影像学倡议（ADNI）用于MRI（结构和功能）和PET（淀粉样蛋白， tau，fdg）。结果变量是由特定于模态分析节点得出的，每个模态分析了 由一个具有专业知识的神经影像生物标志物的实验室。核心将利用NIA赞助 目前支持正在进行的大规模广告神经影像学计划的资源（例如，ADNI，主要是 继承的阿尔茨海默氏症网络（Dian）提供了一条完全开发的数据访问管道，以鼓励科学 DS中神经影像学生物标志物的研究。