Administration Core

行政核心

• 批准号: 10452578
• 负责人: MICHAEL R BAILEY
• 金额: $ 11.5万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10452578
• 关键词: Accounting; Address; Advisory Committees; Agreement; Annual Reports; Applied Research; Area; Basic Science; Biostatistics Core; Budgets; Clinical; Clinical Trials; Clinical Trials Data Monitoring Committees; Collaborations; Communication; Communities; Complex; Critiques; Data; Devices; Disease; Documentation; Electronic Mail; Elements; Engineering; Ensure; Excision; Funding; Goals; Health; Human Resources; Illinois; Indiana; Individual; Institution; Institutional Review Boards; International; Investigation; Kidney Calculi; Laboratories; Leadership; Learning; Manuscripts; Mechanics; Mediation; Modification; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrolithiasis; Notification; Paper; Physics; Preparation; Productivity; Progress Reports; Public Health; Publishing; Recommendation; Records; Reporting; Reproducibility; Research; Research Personnel; Resources; Safety; Schedule; Science; Surgical Management; Technology; Time; Touch sensation; Translational Research; Underrepresented Minority; United States National Institutes of Health; Universities; Urinary Calculi; Urology; Washington; Woman; Work; base; data sharing; experience; imaging system; improved; meetings; member; outreach; programs; recruit; safety study; success; symposium; synergism; ultrasound; Accounting; Address; Advisory Committees; Agreement; Annual Reports; Applied Research; Area; Basic Science; Biostatistics Core; Budgets; Clinical; Clinical Trials; Clinical Trials Data Monitoring Committees; Collaborations; Communication; Communities; Complex; Critiques; Data; Devices; Disease; Documentation; Electronic Mail; Elements; Engineering; Ensure; Excision; Funding; Goals; Health; Human Resources; Illinois; Indiana; Individual; Institution; Institutional Review Boards; International; Investigation; Kidney Calculi; Laboratories; Leadership; Learning; Manuscripts; Mechanics; Mediation; Modification; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrolithiasis; Notification; Paper; Physics; Preparation; Productivity; Progress Reports; Public Health; Publishing; Recommendation; Records; Reporting; Reproducibility; Research; Research Personnel; Resources; Safety; Schedule; Science; Surgical Management; Technology; Time; Touch sensation; Translational Research; Underrepresented Minority; United States National Institutes of Health; Universities; Urinary Calculi; Urology; Washington; Woman; Work; base; data sharing; experience; imaging system; improved; meetings; member; outreach; programs; recruit; safety study; success; symposium; synergism; ultrasound

PROJECT SUMMARY/ABSTRACT - Administration Core (Core A) In this renewal application, we propose the basic and applied research needed to advance an entirely new concept for the non-invasive surgical management of kidney stones. During the next funding period, we will develop and deliver a multifunctional integrated ultrasound-based therapy system that images, breaks, detaches and expels stones. This will be a significant undertaking. The research will be performed at five institutions and involve a team of over 50 researchers, staff, consultants, and advisors. The overall research strategy is complex. The numerous synergistic interactions among the Projects and Cores will require careful coordination. For these reasons a robust Administration Core is essential to the success of the Program. We are in Year-24 of this PPG. Over this time, we have enjoyed remarkable stability among the participating institutions and our key personnel. The current proposal includes two Projects (Projects 1 & 2) at the Applied Physics Laboratory (APL)-University of Washington (UW) with subcontracts/sub-budgets to CalTech, and the UW Departments of Urology and Mechanical Engineering. A third Project (Project 3) is at Indiana University (IU) with subcontracts to IU-Health, Oxford University, and the University of Illinois. The Administration Core (Core A) and the Engineering Core (Core C) will be at the APL-UW, while the Statistical Core (Core B) will be at IU. We have a Board of Directors to oversee clinical impact, an External Advisory Board to assure rigor and reproducibility, a Data Safety Monitor Board for safety review of clinical trials, and a study monitor to assure regulatory compliance. In our experience the main challenge seen in administering a multi-institutional Program such as ours is in keeping the individual teams on track, working continually toward completion of shared goals and objectives. We have had tremendous success at this. The key to what we have been able to accomplish distills down to several essential elements. Our investigators are skilled at collaborative science, we work extremely well together, as individuals we are dedicated to the overall success of the group, and we build by keeping communication at a very high level. This is successful team science facilitated by strong executive leadership. Specifically, Core A provides fiscal, scientific, and regulatory leadership for the Program Project as follows: ● Aim 1. Provide fiscal stewardship; ● Aim 2. Facilitate scientific progress and productivity; ● Aim 3. Promote and monitor synergistic collaboration among the Projects and enable productive utilization of Core resources; ● Aim 4. Liaise with PPG advisors, safety and study monitors, and the NIDDK; ● Aim 5. Maintain regulatory approval and compliance.

项目摘要/摘要 - 管理核心（核心A） 在此续签应用中，我们提出了促进全新的基础和应用研究 肾结石非侵入性手术管理的概念。在下一个资金期间，我们将 开发和提供基于多功能超声的多功能治疗系统，该系统图像，破裂， 分离并驱逐石头。这将是一项重要的事业。该研究将在五个 机构，涉及由50多名研究人员，员工，顾问和顾问组成的团队。总体研究 策略很复杂。项目和核心之间的众多协同互动将需要谨慎 协调。由于这些原因，强大的管理核心对于该计划的成功至关重要。 我们是该PPG的24年。在这段时间里，我们在 参与机构和我们的关键人员。当前的建议包括两个项目（项目1和2） 华盛顿（UW）的应用物理实验室（APL），分包合同/副本 加州理工学院，以及泌尿外科和机械工程的UW部门。第三个项目（项目3）在 印第安纳大学（IU），分包给IU-Health，牛津大学和伊利诺伊大学。这 管理核心（核心A）和工程核心（核心C）将在APL-UW，而统计 核心（核心B）将在IU。我们有一个董事会来监督临床影响，这是一项外部咨询 董事会确保严格和可重复性，数据安全监控委员会，用于临床试验的安全审查， 研究监控器以确保法规合规性。 根据我们的经验 保持各个团队步入正轨，不断努力完成共同的目标和目标。 我们在这方面取得了巨大的成功。我们能够完成蒸馏的关键 几个基本要素。我们的调查人员在协作科学方面熟练，我们的工作非常好 作为个人，我们致力于该小组的整体成功，我们通过保持 沟通很高。这是由强大的执行领导力准备的成功团队科学。 具体而言，核心A为该计划项目提供了财政，科学和监管领导，如下所示： ●AIM 1。提供财政管理； ●目标2。促进科学进步和生产力； ●AIM 3。促进和监视项目之间的协同协作并启用产品 利用核心资源； ●AIM 4。与PPG顾问，安全和学习监视器以及NIDDK联络； ●AIM 5。维持法规批准和合规性。