Regenerative Musculoskeletal Medicine Training Program

再生肌肉骨骼医学培训计划

• 批准号: 10451578
• 负责人: John S Adams
• 金额: $ 35.15万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-11 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10451578
• 关键词: Medicine; Musculoskeletal; Training Programs; regenerative

Project Summary Over the past ten years, we have established a training program focused on regenerative medicine as it relates to musculoskeletal disease. Projects undertaken by trainees have addressed mechanisms underlying musculoskeletal cell commitment and differentiation in development and disease, reconstitution of injured or missing musculoskeletal tissues with cells, scaffolds and bioactive molecules, use of bioinformatics to address musculoskeletal diseases and treatment, and strategies to combat implant infections. One of the most unique attributes of our program is the development of a training experience for orthopaedic surgery residents that enables them to complete a laboratory-based research project connected to a clinical/ translational extension of the project within the confines of the residency program. This led to the development of another unique aspect of our program, a mentoring team for both MD and PhD trainees comprised of an extramurally-funded basic or translational scientist, a funded clinician scientist and a practicing academic surgeon mentor. These new components have been highly successful, leading to substantially increased interest among faculty and trainees and increased interaction between MD and PhD trainees. We propose to expand from four trainee positions to five owing to a tripling in the number of qualified applicants applying to the program in the last three solicitations. The Chair of the UCLA Department of Orthopaedic Surgery has pledged funds to cover operational costs of this expansion and to enrich the overall training experience. Grounded in a pilot study performed in the current funding period, we propose to improve our evaluation of trainees and mentors by using quantifiable metrics around standardized survey-based instruments that track the longitudinal progress of training team members. Based on input from advisory boards and trainees, we diversified our training faculty to include expertise in health services/outcomes and engineering. Finally, with an eye on succession planning, we added a third MPI Nicholas Bernthal, MD, a young faculty member who has succeeded in establishing an extramurally-funded bench research program while maintaining a clinical practice. Our translational research structure is supported by a robust collection of didactic curricula and seminar series designed to introduce and refine the skills needed by postdoctoral trainees to understand, design, compose, undertake and earn extramural financial support for a research project in regenerative medicine. Increased focus will be placed on exposure of PhD trainees to highly relevant clinical challenges and exposure of surgeon scientists to basic research in the field of regenerative orthopaedic medicine. The T32 research and didactic training program is designed to provide individual trainees with 2-3 years of funding in preparation for their transition into more specialized training and to serve as a source of mentoring support that extends beyond their term of appointment to the T32.

项目摘要 在过去的十年中，我们建立了一项针对再生医学的培训计划 致肌肉骨骼疾病。学员开展的项目已经解决了基础的机制 肌肉骨骼细胞的承诺以及发育和疾病的分化，受伤或 缺少带有细胞，支架和生物活性分子的肌肉骨骼组织，使用生物信息学来解决 肌肉骨骼疾病和治疗，以及打击植入物感染的策略。最独特的 我们计划的属性是为骨科手术居民开发培训经验 使他们能够完成与临床/翻译扩展相关的基于实验室的研究项目 居住计划范围内的项目。这导致了另一个独特的发展 我们计划的方面是由室外资助的MD和PhD学员的指导团队 基础或翻译科学家，资助的临床医生和实践学术外科医生导师。 这些新组成部分非常成功，导致教师之间的兴趣大大增加 和学员以及MD和PhD学员之间的互动增加。我们建议从四个学员扩展 由于申请该计划的合格申请人人数增加了三倍，因此位置为五个 三个招标。 UCLA骨科手术部主席已承诺资金覆盖 这种扩展的运营成本并丰富整体培训经验。基于试点研究 在当前的资助期间，我们建议通过 在基于标准化的基于调查的仪器周围使用可量化的指标，以跟踪 培训团队成员。根据咨询委员会和学员的意见，我们将培训学院多样化为 在卫生服务/成果和工程方面包括专业知识。最后，关注继任计划， 我们添加了第三个MPI Nicholas Bernthal，医学博士，是一位年轻的教职员工，他成功建立了 在维持临床实践的同时，由外部资助的基准研究计划。 我们的翻译研究结构得到了强大的教学课程和研讨会系列的支持 旨在介绍和完善博士后学员所需的技能，以了解，设计，组成， 为再生医学研究项目提供并赢得校外财政支持。增加 将重点放在博士学位受训者面临高度相关的临床挑战和暴露的关注点上 外科医生科学家从事再生骨科医学领域的基础研究。 T32研究和 教学培训计划旨在为单个学员提供2 - 3年的资金，以准备 他们过渡到更专业的培训，并作为扩展的指导支持来源 除了任命T32的任期。