CORE E: Samples and Data Management Core

核心 E：样本和数据管理核心

• 批准号: 10450800
• 负责人: GEOFFREY DAVID CLARKE
• 金额: $ 13.5万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2023-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10450800
• 关键词: Age; Aging; Animals; Behavior; Biological Models; Biological Process; Biology; Brain; Communication; Complex; Computer software; Data; Data Analyses; Databases; Development; Ensure; Equipment and supply inventories; Fetal Growth Retardation; Funding; Genetic Transcription; Genomics; Goals; Hormones; Hydrocortisone; Individual; Institution; Intervention; Laboratories; Life; Life Cycle Stages; Magnetic Resonance Imaging; Measurement; Measures; Meta-Analysis; Metadata; Modeling; Nature; Outcome; Primates; Process; Publications; Quality Control; Records; Research Personnel; Resource Sharing; Resources; Sampling; Science; Scientist; Secure; Security; Services; Ships; Source; Statistical Data Interpretation; System; Tissue Sample; United States National Institutes of Health; Update; Uterus; Work; data management; data repository; data sharing; design; flexibility; heart function; high standard; improved; insight; preservation; programs; sex; tissue archive

D. DATA AND SAMPLES MANAGEMENT CORE ABSTRACT This U19 is multi-institutional, which requires careful consideration of all stakeholders involved at different levels of the project. The overall goal is to produce various products including publications, assessable curated databases, biological models and insights that will lead to various other funded projects. The design of our studies includes animals across certain spans of ages undergoing several different types of interventions. This enables inferences regarding the effect of life conditions such as intrauterine growth restriction (IUGR) on life course outcomes (e.g. behavior, brain development, heart function measures, RNA expression, and others) that encompass biological processes at multiple hierarchical levels. By including age and sex and certain driver hormones (e.g. cortisol) as possible predictors in a regression model, more complex and realistic effects can be elucidated. Making the data available so that it can be used to develop complex biological models and meta-analyses ensure utility the data collected is optimized. Core E deals with sample inventory and data management. The Core Unit tasks will be divided into two main activities, sample management and data management. Both will implement quality control (QC) verifications to improve efficiency, maintain security and enhance resource sharing. Initial data analysis is performed in the Scientific Cores (Cores B-D) with Core E designing a Central Data Repository (CDR) to facilitate centralized statistical analysis and integrated outcomes using data from all three Projects. We will share data among our individual Core Projects and (perhaps even more important) work with that shared data to collaborate on gaining insights into the biology that can only arise from such cross-project cooperation. We also will develop systems to allow sharing of data with other qualified investigators world- wide. Aim 1: To develop and provide processes for the daily support of sample inventory and continuous management and updating of the sample metadata and measurement data derived from the samples and software support associated with the primate records database. Aim 2: To develop a process for data management within a secure system streamlined for communications and data sharing amongst the Projects, Cores and institutions involved in this U19 project. Aim 3: To develop and incorporate a curated Central Data Repository (CDR) that will make product data available to all U19 scientists and other stakeholders through an easily accessible user interface, in a secure, flexible and scalable manner.

D.数据和样本管理核心 抽象的 该U19是多机构的，需要仔细考虑不同的所有利益相关者 项目的级别。总体目标是生产各种产品，包括出版物，可评估的策划 数据库，生物模型和见解将导致其他各种资助的项目。 我们的研究的设计包括经历了几种不同类型的年龄段的动物 干预措施。这可以推断出诸如宫内生长等生命状况的影响 限制（IUGR）对生活过程的限制（例如行为，大脑发育，心脏功能措施，RNA 表达式，其他）涵盖了多个层次级别的生物过程。包括年龄 在回归模型中，性别和某些驱动激素（例如皮质醇）作为可能的预测因子，更复杂 可以阐明现实效果。使数据可用，以便可以用于开发复杂 生物模型和荟萃分析可确保效用该数据已优化。 核心E涉及样本库存和数据管理。核心单位任务将分为两个主要 活动，样本管理和数据管理。两者都将实施质量控制（QC）验证 提高效率，保持安全性并增强资源共享。初始数据分析是在 具有核心E设计中央数据存储库（CDR）的科学核心（核B-D），以促进集中式 使用所有三个项目的数据进行统计分析和集成结果。 我们将在各个核心项目之间共享数据，并（也许更重要）与之合作 共享数据以合作获得对生物学的见解，只能由这种跨项目产生 合作。我们还将开发系统，以允许与其他合格的研究者世界共享数据 - 宽的。 目标1：开发和提供流程，以每天支持样本库存和连续 样本元数据的管理和更新以及从样本中得出的测量数据 与灵长类记录数据库相关的软件支持。 目标2：在简化通信的安全系统中开发数据管理过程 以及该U19项目涉及的项目，核心和机构之间的数据共享。 目标3：开发和合并一个将制作产品数据的策划的中央数据存储库（CDR） 通过安全的，可访问的U19科学家和其他利益相关者可访问 灵活，可扩展的方式。