1/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-India

1/2-GEOHealth 整个生命过程中选定环境暴露体的健康影响 (HEALS)-印度

基本信息

批准号：
10447834
负责人：
Dorairaj Prabhakaran
金额：
$ 32.57万
依托单位：
CENTRE FOR CHRONIC DISEASE CONTROL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-28 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10447834
关键词：
Address Adolescence Adolescent Adult Advisory Committees Affect Aging Air Pollutants Air Pollution Anthropometry Area Birth Blood Pressure Caliber Carbon Cardiovascular Diseases Cardiovascular system Child Childhood Chronic Chronic Disease Complex Country Cross-Sectional Studies DNA Methylation Data Development Education Elderly Environmental Exposure Environmental Health Epigenetic Process Future Gender Genomic Segment Gestational Diabetes Glucose Grant Growth Health Human Resources Hypertension Impaired cognition Incidence Income India Individual Inequality Insulin Intervention Joints Level of Evidence Life Life Cycle Stages Link Location Long-Term Effects Longevity Low Birth Weight Infant Measurement Measures Mediating Mentors Metabolism Metals Meteorology Modeling Modification Monitor Myocardial Infarction Nerve Degeneration Nitrogen Dioxide Non-Insulin-Dependent Diabetes Mellitus Outcome Ozone Participant Particulate Matter Pattern Physical Performance Policies Pollution Population Populations at Risk Pre-Eclampsia Pregnancy Pregnancy Complications Premature Birth Public Health Research Research Infrastructure Research Support Research Training Resolution Retrospective Studies Risk Role Rural Sampling Scanning Science Scientist Socioeconomic Status Temperature Testing Time Training Vulnerable Populations Work adverse birth outcomes age related arterial stiffness base cognitive development cohort early childhood epigenome experience extreme temperature fine particles frailty human old age (65+)improved indexing infancy infrastructure development land use low and middle-income countries machine learning prediction methylation pattern mortality muscle strength novel strategies predictive modeling programs sex socioeconomics spatiotemporal therapy design urban setting

项目摘要

Project Summary Air pollution represents a major public health threat in India, affecting a quarter of the country’s population at extreme levels. The evidence on health impacts of air pollution, which mainly comes from high income countries, is not transferable to LMICs like India with complex urban environments and high pollution levels. The proposal entitled “1/2-GEOHealth Health Effects of Selected Environmental Exposomes Across the Life CourSe (HEALS)-India” builds on the research and infrastructure established in the ongoing (to be completed on 7/30/2021), Air pollution and Health GEOHealth Program. In the current proposal we aim to extend our exposure assessments to include a range of air pollutants: particulate matter with aerodynamic diameter <2.5m (PM2.5), nitrogen dioxide (NO2) and ozone (O3), and extremes of temperature to assess the exposomes at fine spatiotemporal resolutions across different locations in India (Delhi, Chennai, Sonipat, Vizag, Pune, Hyderabad and Bikaner). Additionally, we will evaluate the composition of PM2.5 in these locations and measure real time exposures in a subset of the participants. These exposomes will be related to a range of chronic non- communicable diseases across the life course using inter-digitating cohorts. This will be achieved by leveraging existing pregnancy, children, adult, and older adult cohorts across India. This will help us systematically assess the vulnerable populations across pregnancy, infancy, childhood, adolescence, adult and older adult groups. We will also address how environmental exposomes interact with gender, socio-economic status, rural-urban settings, and pre-existing illnesses in impacting the health outcomes. Further, we will replicate the findings from our epigenome-wide scan (from the ongoing study) in larger set of samples to validate DNA methylation profiles associated with incident myocardial infarction and explore if these epigenetic mechanisms mediate the effect of exposomes on myocardial infarction. Through this joint application, we will accelerate scientific infrastructure development, enhance research training to support research needed to characterize the relationship between environmental exposomes and health outcomes across the lifespan in India. The study will be led by Dr. Prabhakaran from CCDC and Dr. Reddy from PHFI and Dr. Schwartz and Dr. Sieber from HSPH, who will be assisted by the: 1) External Advisory Committee; 2) Administrative Oversight Committee; 3) Training Oversight Committee; 4) Program coordination personnel at HSPH and CCDC; and 5) Supervisory teams for individual trainees (Indian & HSPH mentors). The proposed study findings will identify the policy reforms needed to address the growing burden of air pollution and protect the large at-risk population. The training of the Indian scientists in the linked U2R in the area of environmental health will build capacity to undertake relevant studies and apply for future grants to address the threat from adverse environmental exposures in India.

项目概要空气污染是印度主要的公共卫生威胁，影响了该国四分之一的人口空气污染对健康影响的证据主要来自高收入国家，该提案不适用于印度等城市环境复杂、污染程度高的中低收入国家。题为“1/2-GEOHealth 选定的环境暴露物对整个生命周期的健康影响” （治愈）-印度”建立在正在进行的研究和基础设施的基础上（将于 2021 年 7 月 30 日），空气污染与健康 GEOHealth 计划在当前提案中，我们的目标是扩大我们的接触范围。评估包括一系列空气污染物：空气动力学直径<2.5μm的颗粒物（PM2.5），二氧化氮 (NO2) 和臭氧 (O3) 以及极端温度来评估精细条件下的暴露组印度不同地点（德里、钦奈、索尼帕特、维扎格、浦那、海得拉巴）的时空分辨率此外，我们还将评估这些地点的PM2.5成分并实时测量一部分参与者的暴露将与一系列慢性非-相关。使用交叉群体来控制整个生命过程中的传染病这将通过利用来实现。印度各地现有的怀孕、儿童、成人和老年人群体这将有助于我们系统地评估。怀孕、婴儿、儿童、青少年、成人和老年人群体中的弱势群体。还将讨论环境暴露如何与性别、社会经济地位、城乡关系相互作用此外，我们将复制研究结果。我们对大量样本进行全表观基因组扫描（来自正在进行的研究），以验证 DNA 甲基化谱与心肌梗塞事件相关，并探讨这些表观遗传机制是否介导通过这次联合应用，我们将加快科学基础设施的建设。发展，加强研究培训，以支持描述之间关系所需的研究该研究将由印度的环境暴露组和整个生命周期的健康结果领导。来自 CCDC 的 Prabhakaran 和来自 PHFI 的 Reddy 博士以及来自 HSPH 的 Schwartz 博士和 Sieber 博士，他们将由以下机构协助： 1) 外部咨询委员会； 2) 行政监督委员会； 3) 培训监督委员会； 4) HSPH 和 CCDC 的项目协调人员；以及 5) 个人监督小组；拟议的研究结果将确定解决问题所需的政策改革。日益严重的空气污染负担并保护大量高危人群对印度科学家的培训。在环境卫生领域相关的U2R中，将建设进行相关研究和应用的能力未来拨款以解决印度不利环境暴露的威胁。