Vermont Center for Cardiovascular and Brain Health

佛蒙特州心血管和脑健康中心

• 批准号: 10447825
• 负责人: MARY CUSHMAN
• 金额: $ 231.58万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10447825
• 关键词: Address; American; American Heart Association; Area; Basic Science; Blood Vessels; Brain Diseases; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Centers of Research Excellence; Cessation of life; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Core Facility; Custom; Dementia; Development; Discipline; Disease; Education; Electrophysiology (science); Epidemiology; Ethnic Origin; Evaluation; Evolution; Faculty; Fostering; Funding; Future; Gender; Goals; Grant; Heart Diseases; Image; Impaired cognition; Infrastructure; Interdisciplinary Study; Mentors; Mentorship; Microvascular Dysfunction; Molecular Epidemiology; Myocardial Infarction; Organ; Persons; Phase; Physiology; Process; Program Development; Race; Research; Research Design; Research Institute; Research Personnel; Research Support; Resources; Role; Science; Scientist; Stroke; Teacher Professional Development; Training; United States; United States National Institutes of Health; Universities; Vermont; Whole Organism; Work; base; brain health; brain research; cardiovascular health; career; clinical epidemiology; cognitive function; cohesion; college; cost; disability; early-career faculty; experience; innovation; instrumentation; meetings; member; mortality; multidisciplinary; neurovascular; next generation; novel; optimal treatments; peer coaching; programs; recruit; skills; success; supportive environment; symposium; synergism; vascular cognitive impairment and dementia

PROJECT SUMMARY Cardiovascular disease is the #1 cause of mortality in the United States and stroke is the #5 cause. Stroke is also the #1 cause of disability, and it, along with covert neurovascular disease including small vessel disease of the brain, leads to Vascular Cognitive Impairment and Dementia (VCID). Each year 800,000 Americans have a stroke and 720,000 Americans have myocardial infarction. There will be 75 million people with dementia by 2030 and 131 million by 2050. Direct annual costs of cardiovascular disease and stroke are $318 billion and dementia $277 billion. The American Heart Association issued a Presidential Advisory in 2017 highlighting the central role of cardiovascular health to brain health and cognitive function. Much of VCID is driven by increases in covert stroke and small vessel disease of the brain, research areas of expertise for the PIs of this application. To address these issues, this University of Vermont (UVM) Center on Cardiovascular and Brain Health (VCCBH) will leverage NIH funding and institutional commitment to convene multidisciplinary researchers across career stages to determine causes and suggest optimal treatments for cardiovascular and neurovascular disease, including stroke and VCID. We have selected four junior faculty (Project Directors, PDs), from three departments and two UVM colleges, through a rigorous selection process. The VCCBH will support the PDs' transition to independence using a Strategic Mentoring Initiative (SMI), Faculty Development Program (FDP), and assistance and education from two new Core facilities. The SMI will employ multidisciplinary Mentor Teams, including Peer Mentors. The FDP will comprise several educational programs highlighted by an annual 2-Day Research Symposium, and an impactful Pilot Grant program (supported by institutional commitments) that will provide $200,000 to four interdisciplinary research teams of junior faculty. We will establish two new Core facilities: Study Design and Molecular Epidemiology, and Customized Physiology and Imaging. A pipeline of new project directors will be developed from a pool of 19 current candidates and five new junior faculty, who will be recruited with committed institutional support. Capstones of the Center will include continual quality evaluation, clear communication and commitment to diversity. By the completion of Phase I of funding, the Center will be on a strong path to sustainability in research excellence.

项目摘要 心血管疾病是美国死亡率的第一名，中风是＃5原因。中风是 这也是残疾的第一起原因，以及秘密神经血管疾病，包括小血管疾病 大脑，导致血管认知障碍和痴呆（VCID）。每年有80万美国人有 中风和72万美国人有心肌梗塞。将有7500万患有痴呆症的人 到2050年，2030年和1.31亿。直接每年的心血管疾病和中风费用为3180亿美元， 痴呆症2770亿美元。美国心脏协会于2017年发布了总统咨询 心血管健康对大脑健康和认知功能的中心作用。大部分VCID由增加驱动 在秘密中风和大脑小血管疾病中，PIS的专业知识研究领域 应用。为了解决这些问题，佛蒙特大学（UVM）心血管和大脑中心 健康（VCCBH）将利用NIH资金和机构承诺来汇总多学科 跨职业阶段的研究人员确定原因并建议对心血管和 神经血管疾病，包括中风和VCID。我们选择了四个初级教师（项目主任， PDS），来自三个部门和两所UVM大学，通过严格的选择过程。 VCCBH会 使用战略指导计划（SMI），教师发展支持PDS向独立的过渡 计划（FDP），以及两个新的核心设施的援助和教育。 SMI将雇用 多学科导师团队，包括同伴导师。 FDP将包括几个教育计划 由年度为期2天的研究研讨会和有影响力的试点赠款计划强调（由 机构承诺）将为四个初级教师的跨学科研究团队提供200,000美元。 我们将建立两个新的核心设施：研究设计和分子流行病学，并定制 生理学和成像。新项目董事的管道将从19个电流的池开发 候选人和五个新的初级教师将在机构支持下招募。卡体的 该中心将包括持续的质量评估，清晰的沟通和对多样性的承诺。由 I阶段资金的完成，该中心将在研究卓越的可持续性方面处于强大的途径。