Core D: Cardiometabolic Phenotyping Core

核心 D：心脏代谢表型核心

• 批准号: 10447068
• 负责人: Jonathan Mark Brown
• 金额: $ 25.76万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10447068
• 关键词: Adipose tissue; Animal Model; Animal Sources; Animals; Area; Atherosclerosis; Bile Acids; Bioinformatics; Blood Platelets; Cardiometabolic Disease; Cells; Clinic; Clinical; Collaborations; Controlled Environment; Coupled; Development; Diet; Disease; Energy Metabolism; Engineering; Ensure; Formulation; Genotype; Germ; Germ-Free; Gnotobiotic; Goals; Human; Individual; Insulin; Investigation; Lesion; Lipids; Lipoproteins; Lyase; Mass Spectrum Analysis; Metabolic; Metabolism; Metagenomics; Methodology; Methods; Modeling; Mus; Obesity; Pathogenesis; Pathway interactions; Performance; Phenotype; Protocols documentation; Reagent; Research Personnel; Research Project Grants; Role; Sampling; Services; Standardization; Sterilization; Study models; Sulfate; System; Technical Expertise; Thrombosis; Tissues; Tracer; Training Support; Transplantation; Universities; Work; bile acid metabolism; blood glucose regulation; cardiometabolism; chemical synthesis; data sharing; design; disease phenotype; gut microbes; gut microbiota; in vivo; inhibitor; insulin sensitivity; investigator training; metabolomics; microbial; microbial community; microbiome analysis; mouse model; novel strategies; pre-clinical; pressure; programs; seal; small molecule; stable isotope; trait; transcriptome sequencing; trimethylamine

Cardiometabolic Phenotyping Core (Core D). ABSTRACT: The overall goal of the Cardiometabolic Disease Phenotyping Core (Core D) is to provide centralized expertise for performance of state-of-the-art animal model studies relevant to Cardiometabolic Diseases in support of Projects within this Program. This core is necessary to establish consistency in mouse phenotyping studies performed across all three Projects, and will ensure seamless data sharing and comparison of how each of the different gut microbial metabolite pathways under investigation impact cardiometabolic disease in mice. All projects in this PPG propose to examine the impact of select gut microbe-derived metabolites on host cardiometbolic disease phenotypes including atherosclerosis, thrombosis, adiposity, insulin/glucose homeostasis, and altered lipid/bile acid metabolism. Each of these phenotypes requires independent rigorous methods to be carried out by well-trained investigators in each area. The Cardiometabolic Disease Phenotyping Core (Core D) will provide technical expertise in a centralized mouse phenotyping service that will collaboratively interface with all other research projects and cores to examine the effect of altering gut microbial metabolites on cardiometabolic disease phenotypes.

心脏代谢表型核心（核心D）。抽象的： 心脏代谢疾病表型核心（核心D）的总体目标是提供集中的专业知识 为了进行与心脏代谢疾病有关的最先进的动物模型研究，以支持 该程序中的项目。该核心对于在小鼠表型研究中建立一致性是必要的 在所有三个项目中执行，并将确保无缝数据共享和比较每个项目 研究下的不同肠道微生物代谢物途径会影响小鼠心脏代谢疾病。全部 该PPG中的项目提议检查精选的肠道微生物代谢物对宿主的影响 心脏测定疾病表型，包括动脉粥样硬化，血栓形成，肥胖，胰岛素/葡萄糖 稳态，改变脂质/胆汁酸代谢。这些表型中的每一个都需要独立严格 训练有素的研究人员在每个地区进行的方法。心脏代谢疾病 表型核心（核心D）将在集中式鼠标表型服务中提供技术专长 与所有其他研究项目和核心进行协作接口，以检查改变肠道的效果 心脏代谢疾病表型上的微生物代谢产物。