Core B: The Muscle Tissue/Cell Repository and Specialty Diagnostics Core

核心 B：肌肉组织/细胞存储库和专业诊断核心

• 批准号: 10442634
• 负责人: STEVEN A MOORE
• 金额: $ 38.76万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-08 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10442634
• 关键词: Diagnostic; Muscle; Muscular Dystrophies; Research; cell repository; medical specialties

CORE B SUMMARY The Muscle Tissue/Cell Culture/Diagnostics Core of the Iowa Wellstone Muscular Dystrophy Cooperative Research Center is a multifaceted laboratory that serves as a local, national and international resource for research on muscular dystrophy and other neuromuscular diseases. This Core has two major goals. Firstly, it has established and will expand a tissue and cell culture Repository to support basic and translational research efforts. Currently, this Repository contains muscle biopsies from more than 8500 patients with neuromuscular disorders, as well as cryopreserved fibroblasts from more than 425 patients with myopathic disease, predominantly muscular dystrophies. Well-characterized tissues and cells from the Core are made available to research investigators at Iowa as well as other academic centers across the USA and around the world. Secondly, the Core provides specialty diagnostic services that are not readily available through clinical laboratories, and facilitates research on and the development of new diagnostic tests for eventual transfer into clinical laboratories. These diagnostic services are very closely integrated with clinical laboratory testing carried out in the Department of Pathology at the University of Iowa. Together, Core B and the Department of Pathology services provide state-of-the-art diagnostic testing for patients seen at the University of Iowa Hospitals and Clinics, and for patients referred to Iowa from throughout the USA and from several other countries. This infrastructure provides key support for clinical trials of neuromuscular disease.

核心B摘要 爱荷华州韦尔斯通肌营养不良的肌肉组织/细胞培养/诊断核心 研究中心是一个多面实验室，是本地，国家和国际资源 肌肉营养不良和其他神经肌肉疾病的研究。该核心有两个主要目标。首先，它 已经建立并将扩大组织和细胞培养库以支持基本和翻译研究 努力。目前，该存储库包含来自8500多名神经肌肉患者的肌肉活检 来自425例肌性疾病患者的疾病以及冷冻保存的成纤维细胞， 主要是肌肉营养不良。核心的特征良好的组织和细胞可供使 爱荷华州以及美国和世界各地的其他学术中心的研究研究人员。 其次，核心提供专业诊断服务，这些服务不容易通过临床获得 实验室，并促进了有关最终转移到新诊断测试的研究和开发 临床实验室。这些诊断服务与临床实验室测试非常紧密地集成 在爱荷华大学病理学系进行。核心B和部门 病理服务为爱荷华大学所见的患者提供最新的诊断测试 医院和诊所，适用于全美和其他几个来自美国的爱荷华州的患者 国家。该基础设施为神经肌肉疾病的临床试验提供了关键支持。