Biological Mechanisms Core-RC-2

生物机制核心-RC-2

• 批准号: 10441239
• 负责人: Peter M. Abadir
• 金额: $ 20.4万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441239
• 关键词: Aging; American; Angiotensins; Animal Model; Animals; Area; Attenuated; Autoantibodies; Biocompatible Materials; Bioinformatics; Biological; Biological Assay; Biology; Biology of Aging; Cells; Chronic; Clinical; Clinical Research; Collaborations; Communication; Computing Methodologies; Data Analyses; Development; Diagnostic; Elderly; Enzyme-Linked Immunosorbent Assay; Etiology; Faculty; Fostering; Functional disorder; Funding; Genetic; Genomics; Gerontology; Goals; Inflammation; Information Dissemination; Infrastructure; International; Intervention; Knowledge; Laboratories; Leadership; Link; Measurement; Mentors; Mentorship; Mitochondria; Modality; Molecular; Molecular Computations; Nanotechnology; Pathway interactions; Phenotype; Prevention; Prevention strategy; Preventive treatment; Proteomics; Psychological Transfer; Receptor, Angiotensin, Type 1; Research; Research Design; Research Personnel; Resources; Sampling; Science; Section 8; Source; System; Technology; Technology Transfer; Testing; Therapeutic; Training; Translating; Translations; Tweens; Vendor; Work; age related; aptamer; base; clinically relevant; cost effective; diagnostic strategy; drug development; frailty; human subject; insight; interest; metabolomics; model development; mouse model; next generation; novel; physical property; prevent; therapy development; tool; treatment strategy

Resource Core 2 (RC2) Biological Mechanisms Core: Project Summary The identification of the etiologies of frailty and age-related vulnerability remains a crucial challenge for gerontological research. Key to this challenge are the development of a better understanding of the underlying biological basis that contributes to frailty and the identification of key biological pathways for the development of interventions that might help prevent or alleviate frailty and loss of independence. The goal of Johns Hopkins Older Americans Independence Center (OAIC) Biological Mechanisms Core (RC-2) is to enable the next generation of frailty-related etiological discovery and to promote the translation of these discoveries into clinically relevant diagnostic, preventive, and treatment modalities. This core achieves this through the provision of high-quality biological measurement expertise, technologies, and infrastructure necessary to attain this goal. In order to comprehensively encompass the biological and measurement expertise necessary to study frailty-related etiology, we have engaged a leadership team with considerable biological and translational expertise as well as several internal consultants who bring crucial additional expertise, mentorship for trainees, and infrastructure to RC-2. The specific aims of RC-2 are to: 1) provide state of the art scientific expertise, infrastructure, and technology necessary to advance biological and etiological research related to frailty, 2) provide access to biological samples from human subjects and from animal models necessary to test hypotheses related to frailty, 3) facilitate the translation of biological findings into interventions or prevention-focused clinical studies, 4) provide training, mentorship, and guidance to promising junior investigators around biological mechanisms that impact frailty, and 5) provide institutional and external visibility for RC-2 related science and activities. These visibility efforts will be further facilitated by a novel Information Dissemination Core (IDC) as described in section 8. Our aims will be accomplished through close communication between the core leaders and their laboratories, close partnership with the other OAIC cores, and the engagement of expert consultants in the highly relevant areas of mitochondrial measurement, metabolomics, mouse model development, nanotechnologies for diagnostic purposes, and nanotechnology related to drug development. By providing these resources, RC-2 will foster high quality research that elucidates clinically relevant biological pathways that underlie frailty and related interventions that hold promise to attenuate frailty, related conditions, and the loss of independence.

资源核心 2 (RC2) 生物机制核心：项目摘要 确定衰弱和与年龄相关的脆弱性的病因仍然是一个重大挑战 老年学研究。这一挑战的关键是更好地理解 导致虚弱的潜在生物学基础和关键生物学途径的确定 制定可能有助于预防或减轻脆弱和独立性丧失的干预措施。目标 约翰霍普金斯大学美国老年人独立中心 (OAIC) 生物机制核心 (RC-2) 的目的是 促进下一代与衰弱相关的病因学发现并促进这些成果的转化 临床相关诊断、预防和治疗方式的发现。该核心实现了这一点 通过提供高质量的生物测量专业知识、技术和基础设施 实现这一目标所必需的。为了全面涵盖生物学和测量 研究衰弱相关病因所需的专业知识，我们聘请了一支具有相当多经验的领导团队 生物学和转化专业知识以及几位内部顾问带来了重要的额外知识 RC-2 的专业知识、受训者指导和基础设施。 RC-2 的具体目标是： 1) 提供 先进的科学专业知识、基础设施和技术是推进生物和生物技术发展所必需的 与虚弱相关的病因学研究，2) 提供从人类受试者和来自 测试与衰弱相关的假设所必需的动物模型，3）促进生物学的转化 干预措施或以预防为重点的临床研究的结果，4) 提供培训、指导和 围绕影响虚弱的生物机制向有前途的初级研究人员提供指导，以及 5) 提供 RC-2 相关科学和活动的机构和外部知名度。这些可见性努力将 第 8 节中描述的新颖的信息传播核心 (IDC) 进一步促进了这一点。我们的目标是 通过核心领导与其实验室的密切沟通来完成， 与其他 OAIC 核心的伙伴关系，以及在高度相关的领域聘请专家顾问 线粒体测量、代谢组学、小鼠模型开发、纳米技术等领域 诊断目的以及与药物开发相关的纳米技术。通过提供这些资源，RC-2 将促进高质量的研究，阐明导致虚弱和疾病的临床相关生物学途径 相关干预措施有望减轻虚弱、相关状况和独立性的丧失。