Exposure to PFNA and other PFAS in drinking water and associations with health-related outcomes in Gloucester County NJ

新泽西州格洛斯特县饮用水中 PFNA 和其他 PFAS 的暴露及其与健康相关结果的关联

• 批准号: 10441045
• 负责人: ROBERT John LAUMBACH
• 金额: $ 125万
• 依托单位: RBHS-SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441045
• 关键词: Exposure; PFNA; other; PFAS; drinking

PROJECT SUMMARY The Agency for Toxic Substances and Disease Registry (ATSDR) has identified the need for additional epidemiological research on the health effects of poly- and perfluoroalkyl substances (PFAS) exposures, particularly from contaminated drinking water and for compounds even less studied than perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), such as perfluorononanoic acid (PFNA). The highest levels of PFNA contamination in public and private water wells recorded anywhere in the world were found in Paulsboro and West Deptford New Jersey, where measurable levels of other poly- and perfluoroalkyl substances (PFAS) were also detected. Contaminated drinking water is an important and growing source of exposure to PFNA and other PFAS, and it estimated that millions of adults and children are exposed to PFAS in drinking water. Associations between serum PFAS levels in the general population and a wide range of health effects have been reported, but relatively little is known about health effects from consuming water contaminated with PFAS. There is a critical need to better understand the health hazards and risks of PFNA and other PFAS in drinking water. The main objective of this proposal is to evaluate associations between health outcomes and multiple estimates of exposure to PFNA and other PFAS among members of these communities and the other study sites in a multi-site study. A number of hypotheses will be tested, including that exposure to PFNA and other PFAS are associated with blood lipid levels, renal function and kidney disease, thyroid hormones and disease, liver function and disease, glycemic parameters and diabetes, and immune response and function in both children and adults. Additional hypothesized effects to be studied include differences in sex hormones and sexual maturation, vaccine response, and neurobehavioral outcomes in children, as well as cardiovascular disease, osteoarthritis and osteoporosis, endometriosis, and autoimmune disease in adults. The rationale for these multiple cross-sectional analyses is to test hypotheses for which there is sufficient statistical power based on prior reports, to develop new hypotheses, and to build a foundation for future knowledge generation with members of these communities. As part of the multi-site study with a target enrollment of 6,000 adults and 2000 children, 1,000 adults and 350 children from the Paulsboro and West Deptford municipalities who consumed water from wells contaminated with PFNA and other PFAS will be enrolled. Assessment of exposure to PFAS will be based on blood concentrations of PFAS and drinking water exposure reconstruction and PBPK modeling of internal exposure, including development of novel models for PFNA. Estimation of associations between health outcomes and measured and modeled exposure to PFAS will be done for this site and across sites of this multi-site study. The proposed project is relevant to public health, because our results will strengthen the evidence basis for making decisions about policies and actions to protect human health when people may be exposed to PFAS from drinking water.

项目摘要 有毒物质和疾病注册机构（ATSDR）已确定需要额外 关于多氟烷基物质（PFA）暴露的健康影响的流行病学研究， 特别是从受污染的饮用水和与全氟辛酸相比所研究的化合物更少的化合物。 （PFOA）和全氟辛烷磺酸（PFO），例如全氟唱酸（PFNA）。最高水平 在世界各地记录的公共和私人水井中的pfna污染都在 Paulsboro和West Deptford新泽西 还检测到物质（PFA）。受污染的饮用水是重要且不断增长的来源 暴露于PFNA和其他PFA，估计将数百万的成年人和儿童暴露于PFA 在饮用水中。一般人群中血清PFA水平与广泛的血清PFA水平之间的关联 据报道，健康效应，但对消耗水的健康影响相对较少 被PFA污染。迫切需要更好地了解PFNA的健康危害和风险 和其他饮用水中的PFA。该提案的主要目的是评估 健康结果以及对PFNA和其他PFA接触的多次估计成员之间 多站点研究中的社区和其他研究地点。将测试许多假设，包括 暴露于PFNA和其他PFA与血脂水平，肾功能和肾脏有关 疾病，甲状腺激素和疾病，肝功能和疾病，血糖参数和糖尿病，以及 儿童和成人的免疫反应和功能。需要研究的其他假设效果 包括性激素和性成熟，疫苗反应和神经行为结果的差异 在儿童以及心血管疾病，骨关节炎和骨质疏松症，子宫内膜异位症和自身免疫性 成人疾病。这些多个横截面分析的基本原理是检验假设 基于先前的报告，有足够的统计能力，以提出新的假设并建立一个 与这些社区成员的未来知识生成基础。作为多站点研究的一部分 目标入学人数为6,000名成人和2000名儿童，1,000名成年人和350名Paulsboro的儿童 和西迪普特福德市政当局，他们从pfna和其他PFA污染的井中消耗水 将被注册。对PFA的接触评估将基于PFA的血液浓度和饮酒 水暴露重建和内部暴露的PBPK建模，包括开发新型 PFNA的模型。估计健康结果与测量和建模的暴露之间的关联 该站点以及此多站点研究的跨站点将完成PFA。拟议的项目与 公共卫生，因为我们的结果将加强有关政策和政策决定的证据基础 当人们可能暴露于PFA的饮用水中时，保护人类健康的行动。