Contribute to the breeding expansion and to the genetic diversity at California NPRC

为加州 NPRC 的育种扩展和遗传多样性做出贡献

• 批准号: 10440774
• 负责人: Melween I. Martinez
• 金额: $ 23.04万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-04-15 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440774
• 关键词: Accreditation; Acquired Immunodeficiency Syndrome; Administrative Supplement; Admixture; Agreement; Air; Anatomy; Animal Model; Animal Rights; Animals; Biological Warfare; Biomedical Research; Breeding; Businesses; COVID-19; COVID-19 pandemic; California; Caribbean region; Characteristics; Chinese People; Collaborations; Communicable Diseases; Communities; Dengue; Destinations; Development; Discipline; Disease; Evaluation; Funding; Future; Genetic; Genetic Variation; HIV; Health; Human; Human Pathology; Inbreeding; Infectious Agent; Institutes; Institution; International; Island; Journals; Law Enforcement; Leadership; Macaca; Macaca mulatta; Malaria; Medicine; Metabolism; Modeling; Monkeys; Nature; Pathogenesis; Personal Satisfaction; Physiology; Population; Positioning Attribute; Primates; Privatization; Protocols documentation; Puerto Rico; Reporting; Research; Research Personnel; Resources; Science; Secure; Security; Ships; Stress; Study models; Tail; Time; Transportation; Uncertainty; United States National Institutes of Health; biodefense; design; experience; germ free condition; human disease; material transfer agreement; member; nonhuman primate; pressure; programs; structural genomics; vaccine development; virology

Project Summary Nonhuman primates (NHP) models for human disease are essential for biomedical research. The underlying physiology and metabolism, as well as anatomical and genomic structures of nonhuman primates are more similar to humans than are other mammalian animal models. Macaques are the most commonly used nonhuman primates in biomedical research. The similarities between human and rhesus macaques make these animals outstanding models for the study of infectious disease pathogenesis such as in malaria, dengue and Acquired Immunodeficiency Syndrome (AIDS), of vaccine development for a variety of infectious agents, and of human pathologies. In addition, nonhuman primates are needed as models for biodefense research initiatives particularly for vaccine development against agents with potential use in bio-warfare. In 2020, the ongoing unforeseen COVID-19 pandemic added an additional stress to the already tenuous NHP supply by increasing the demand around the world. Because of that, the NPRCs, with the support of NIH/ORIP, launched an initiative to establish the NHP Strategic Reserve (NSR). At the time of the COVID-19 pandemic, the Caribbean Primate Research Center (CPRC) was in the position to supply animals, immediately, in support of COVID-19 research which has resulted in a topmost contribution to science. Scientific results generated with CPRC's contribution are available in top journals like Science, Nature, and Journal of Experimental Medicine among others. In addition, underscoring the value of this NIH/ORIP-funded resource, and as one early step in the development of the NSR, CPRC has been willing and proactively engaged in agreements with some NPRCs in order to supply high quality animals to expand their breeding population and to increase their genetic diversity. This Administrative Supplement seek to supply high quality Indian-origin rhesus macaques, born and breed at the CPRC, to expand the breeding capabilities and the genetic pool at California National Primate Research Center.

项目摘要 人类疾病的非人类灵长类动物（NHP）模型对于生物医学研究至关重要。基础 非人类灵长类动物的生理学和代谢以及解剖学和基因组结构更多 与人类类似于其他哺乳动物模型。猕猴是最常用的非人类 生物医学研究的灵长类动物。人类和恒河猕猴之间的相似之处使这些动物 研究传染病发病机理的杰出模型，例如在疟疾，登革热中并获得 免疫缺陷综合征（AIDS），各种传染剂的疫苗开发和人类 病理。此外，需要非人类灵长类动物作为生物形式研究计划的模型 特别是针对对生物射击潜在使用的药物的疫苗开发。 在2020年，持续的不可预见的Covid-19大流行为已经脆弱的NHP增加了额外的压力 通过增加全球需求来供应。因此，在NIH/Orip的支持下，NPRC， 发起了一项计划，以建立NHP战略储备（NSR）。在COVID-19大流行时， 加勒比灵长类动物研究中心（CPRC）可以立即提供动物，以支持 COVID-19导致对科学的最大贡献的研究。与 CPRC的贡献可在科学，自然和实验医学杂志等顶级期刊中获得 等等。此外，强调了该NIH/Orip资助的资源的价值，并作为早期一步 NSR的发展，CPRC一直愿意并积极与某些NPRC达成协议 为了提供高质量的动物以扩大其繁殖种群并增加遗传 多样性。这种行政补充旨在提供高质量的印度王朝猕猴，出生和 在CPRC上繁殖，以扩大加利福尼亚国家灵长类动物的繁殖能力和遗传池 研究中心。