MyGI Diet for Colorectal Cancer Prevention

MyGI 饮食预防结直肠癌

• 批准号: 10439894
• 负责人: Lorraine R Buis
• 金额: $ 57.92万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10439894
• 关键词: Acetone; Address; Adherence; Adult; Affect; Age; American; American Cancer Society; Back; Biological; Biological Markers; Body Weight decreased; Calories; Caring; Carotenoids; Case Manager; Categories; Characteristics; Chronic Disease; Clinical; Colorectal Cancer; Consumption; Control Groups; Counseling; Data; Developed Countries; Diet; Diet Monitoring; Dietary Intervention; Educational Materials; Energy Intake; Epidemiology; Family history of; Fatty acid glycerol esters; Flour; Food; Future; Goals; Health; Health Personnel; Incidence; Individual; Institutes; Intake; Intervention; Intestinal permeability; Ketones; Lead; Link; Maintenance; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Measures; Meat; Medical; Mediterranean Diet; Methodology; Methods; Monitor; Nutrient; Obesity; Overweight; Participant; Patients; Persons; Physicians; Plants; Prevention; Preventive; Preventive care; Process; Processed Meats; Quality Control; Randomized; Recommendation; Recording of previous events; Research; Risk; Risk Factors; Risk Reduction; Role; Serum Markers; Skin; Spectrum Analysis; Stress; Subgroup; Telephone; Testing; Time; Training; Translating; Weight Gain; Weight maintenance regimen; adult obesity; anticancer research; base; behavior measurement; behavioral outcome; cancer prevention; cancer risk; clinical care; colon cancer risk; colorectal cancer prevention; colorectal cancer risk; cost; dietary; dietary adherence; dietary approach; energy balance; food consumption; fruits and vegetables; healthy weight; high risk; high risk population; implementation facilitation; improved; improved outcome; inflammatory marker; meetings; method development; modifiable risk; non-invasive monitor; nutrition; obese person; obesity treatment; oxidation; primary care setting; primary outcome; randomized trial; recruit; secondary outcome; sugar; tailored messaging; tool; usability; waist circumference; western diet

PROJECT SUMMARY Despite the large body of research that has identified the impact of diet on cancer risk, little has been done to translate these findings to clinical settings. Here we address prevention of colorectal cancer (CRC), the third most prevalent cancer in the U.S. CRC is among the cancers that are most strongly affected by diet and excess adiposity, and incidence is increasing in young people below the age of 40. More efforts need to be directed at providing individuals with the tools needed for achieving and maintaining a preventive diet. Recommendations for cancer prevention from the American Cancer Society and American Institute for Cancer Research include advice to maintain a healthy weight, to consume more plant-based foods, and to limit red meats, processed meats, and foods with added sugar. This proposal addresses the development of methods that could feasibly be implemented in medical settings to assist high risk individuals in attaining both the weight management and diet quality goals for prevention of CRC. Building on our previous trials, this proposal seeks to test two dietary interventions in overweight and obese persons who have a strong family history of CRC or a personal history of CRC. We will recruit 240 participants who will be randomized to receive to 12 months of: 1) a control group that receives written information on preventive diets; 2) a Western Limit Diet that simply encourages limiting foods associated with increased risk of CRC: ultra-processed foods (foods containing refined flour, added sugars, or processed meats) and red meats; or 3) a Comprehensive Diet that combines goals for both limiting Western foods and consuming preventive foods. The two interventions will be supported by written educational materials, brief telephone contacts by case managers, and a different module of the MyGI app for each diet. MyGI incorporates checklists to facilitate real-time goal tracking, tailored messaging, and real-time display of progress made. The dietary changes are expected to improve diet quality and achieve a sustainable, slow rate of weight loss over time that appears to be more favorable for cancer prevention than conventional obesity treatment. The specific aims are: 1) To determine if an intervention limiting Western foods has similar effects as a Comprehensive intervention, versus Control, on the dual primary outcomes of improving diet and achieving modest weight loss in overweight and obese subjects at increased risk of CRC. Secondary outcomes include biological and behavioral measures of intervention adherence, app usability, and serum markers of inflammatory stress. 2) To evaluate whether skin carotenoids (as a biomarker of fruit and vegetables consumption) and breath ketones (as a biomarker of fat oxidation) can be utilized as non-invasive, objective measures of dietary compliance. The long-term goal is to identify an intervention that could be incorporated as part of usual health maintenance care to help high risk patients meet and maintain dietary cancer prevention goals.

项目摘要 尽管大量研究已经确定了饮食对癌症风险的影响，但几乎没有做任何事情 将这些发现转换为临床环境。在这里，我们解决了结直肠癌（CRC）的预防，第三次 美国CRC中最普遍的癌症是最受饮食和过量影响的癌症之一 低于40岁以下的年轻人的肥胖和发病率正在增加。需要针对更多的努力 为个人提供实现和维持预防饮食所需的工具。建议 预防美国癌症学会和美国癌症研究所的癌症包括 建议保持健康的体重，食用更多植物性食物并限制加工的红肉 肉和添加糖的食物。该提案解决了可能可行的方法的开发 在医疗环境中实施，以帮助高风险个人达到体重管理和 预防CRC的饮食质量目标。在我们以前的试验的基础上，该提案旨在测试两个饮食 对拥有CRC家族史或个人历史的超重和肥胖的人进行干预 CRC。我们将招募240名参与者，他们将被随机接收到12个月：1）一个对照组 收到有关预防饮食的书面信息； 2）西方极限饮食只能鼓励限制食物 与CRC风险增加有关：超级加工的食物（含有精制面粉，添加糖或 加工肉）和红肉；或3）全面饮食结合了限制西方的目标 食物和食用预防食品。这两种干预措施将由书面教育材料提供支持， 案例经理的简短电话联系，以及每种饮食的MYGI应用程序的不同模块。 mygi 合并清单，以促进实时目标跟踪，量身定制的消息传递和实时展示进度 制成。饮食变化有望提高饮食质量并达到可持续的，缓慢的体重 随着时间的流逝，似乎比常规肥胖治疗更有利于预防癌症。这 具体目的是：1）确定限制西方食品的干预措施是否具有类似的影响 综合干预措施与控制，以改善饮食和实现的双重主要结果 超重和肥胖受试者的体重减轻适中，CRC风险增加。次要结果包括 炎症的干预依从性，应用可用性和血清标记的生物学和行为度量 压力。 2）评估皮肤类胡萝卜素（作为水果和蔬菜的生物标志物）和呼吸是否是否 酮（作为脂肪氧化的生物标志物）可以用作非侵入性的，客观的饮食方法 遵守。长期目标是确定可以作为通常健康的一部分纳入干预措施 维护护理可帮助高风险患者满足并维持饮食癌症预防目标。