Discovery and optimisation of unconventional yeasts to enable the industrial scaling of alternative protein production using precision fermentation

非常规酵母的发现和优化，以实现利用精密发酵实现替代蛋白质生产的工业规模化

• 批准号: 10074091
• 金额: $ 6.31万
• 依托单位: HERLAB LTD
• 依托单位国家: 英国
• 项目类别: Grant for R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10074091
• 关键词: Discovery; optimisation; unconventional; yeasts; enable

Our food system is facing challenges that require innovative solutions. One emerging solution is alternative proteins, which have the potential to reduce the environmental, ethical, and health impacts of animal agriculture. However, to be a viable alternative, these proteins must achieve taste and price parity with conventional animal-based products.Our innovative yeast technology is designed to meet this challenge. We're using cutting-edge synthetic biology and machine learning tools to identify and develop next-generation yeast strains that are highly efficient and scalable for industrial-scale protein production.Our project focuses on demonstrating the viability of this approach by focusing on two of the most promising species identified by us in the lead-up to this project. Our goal is to use them to produce two biomolecules of economical and environmental significance in food production. If successful, this proof of concept will validate the promise of our yeast screening platform, unlocking the possibility for developing multiple next-generation yeast strains for a more sustainable and more affordable food, cosmetics, and even pharmaceutical ingredient production. Moreover, our approach carries broader implications for the biotechnology industry, as our unique yeast screening platform bears a transformative value for a wide range of active applications.Our innovative approach to sustainable protein production will have a significant positive impact on the environment, public health, and the economy. By reducing dependence on animal agriculture and petroleum-derived ingredients, we can create more sustainable food and health systems that benefit our society.

我们的食品系统面临需要创新解决方案的挑战。一种新兴的解决方案是替代蛋白质，它们具有减少动物农业的环境，道德和健康影响的潜力。但是，要成为可行的替代方案，这些蛋白质必须与常规动物的产品实现口味和价格平等。我们的创新酵母技术旨在应对这一挑战。我们正在使用尖端的合成生物学和机器学习工具来识别和开发对工业规模蛋白质生产的高效且可扩展的下一代酵母菌菌株。我们的项目专注于通过专注于两种方法来证明这种方法的可行性我们在该项目的领导中确定的最有前途的物种。我们的目标是利用它们在粮食生产中产生两种经济和环境意义的生物分子。如果成功的话，此概念证明将验证我们的酵母菌筛查平台的承诺，从而解锁开发多个下一代酵母菌菌株的可能性，从而获得更可持续，更实惠的食物，化妆品，甚至是药物成分的生产。此外，我们的方法对生物技术行业具有更广泛的影响，因为我们独特的酵母菌筛选平台对广泛的活跃应用具有变革性的价值。我们的可持续蛋白质生产的创新方法将对环境，公共卫生，公共卫生，公共卫生，公共卫生，公共卫生，公共卫生产生重大的积极影响和经济。通过减少对动物农业和石油衍生成分的依赖，我们可以创建更可持续的食品和卫生系统，从而使我们的社会受益。