Brief Research In Aging and Interdisciplinary Neurosciences (BRAIN)

衰老和跨学科神经科学的简要研究（BRAIN）

• 批准号: 10436766
• 负责人: MICHIO HIRANO
• 金额: $ 5.96万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436766
• 关键词: Academic Medical Centers; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Authorship; Basic Science; Behavioral Research; Biological; Biomedical Research; Brain imaging; Cerebrum; Clinical Research; Clinical Trials; Cognitive; Disease; Disease Progression; Educational Curriculum; Epidemiology; Epilepsy; Funding; Good Clinical Practice; Institution; Memory; Mentors; Methods; Motor Neuron Disease; Nervous system structure; Neurologic; Neurologist; Neurology; Neuropsychology; Neurosciences; Patients; Positioning Attribute; Research; Research Methodology; Research Training; Resources; Site; Stroke; Structure; Students; Training; Work; career; collaborative approach; education research; executive function; experience; multidisciplinary; nervous system disorder; neurogenetics; neuropathology; posters; pre-clinical; pre-doctoral; programs; summer research; tau Proteins

Project summary The Department of Neurology at Columbia University Medical Center serves as a rich site for multidisciplinary neurological research, with particular focus on the aging nervous system and Alzheimer’s disease and Related Dementias (AD and ADRD). This proposal seeks to continue funding for positions for 20 preclinical students participating in the Brief Research in Aging and Interdisciplinary Neurosciences (BRAIN) program each summer. For the BRAIN program, we have developed a comprehensive approach to develop a formal research program for predoctoral students early in developing careers in biomedical, behavioral and clinical research. The work is collaboratively approached through brief but intensive mentored summer research training experiences for these students. The research training provides opportunities in basic, behavioral and clinical research through ongoing research in the fields of basic neuroscience, neuropathology, neurogenetics, neuropsychology, epidemiology, and clinical trials, with a focus on Alzheimer’s disease and Related Dementias, aging-related motor neuron disease, stroke, and epilepsy, as well as neurologic clinical trials treating patients with these disorders. Methods for inclusion of biological and cognitive markers of neurological disease progression, such as cerebral amyloid and tau, structural brain imaging, as well as assessment of memory, executive function, and other cognitive domains are embedded within the training curriculum. In addition, a comprehensive structured research education curriculum is delivered over the course of the intense research experience, with topics including good clinical practice, basic research methodologies, introductions to abstract authorship and poster presentations, and introduction of statistical concepts and approach to analyses, as well as epidemiologic and pathophysiologic reviews of the most common neurologic disorders such as Alzheimer’s disease. Our institution has the strongest track record of developing academic neurologists of anywhere worldwide, and this short-term, intense program builds upon this wealth of resources through hands-on introductions to neurological research, comprehensive review of principles of research, and thus assures the best opportunity for these students to develop research careers in the field of disorders of the aging nervous system including Alzheimer’s disease.

项目摘要 哥伦比亚大学医学中心神经病学系是多学科神经系统研究的丰富场所，特别关注衰老的神经系统和阿尔茨海默氏病和相关痴呆症（AD和ADRD）。该提案旨在继续为20名临床前学生提供资金，参加每年夏天的简短研究和跨学科神经科学计划（大脑）计划。对于大脑计划，我们已经开发了一种全面的方法，可以在发展生物医学，行为和临床研究的职业早期为专业学生开发正式的研究计划。这项工作是通过简短但深入地为这些学生介绍的夏季研究培训经验而进行协作的。 The research training provides opportunities in basic, behavioral and clinical research through ongoing research in the fields of basic neuroscience, neuropathology, Neurogenetics, neuropsychology, epidemiology, and clinical trials, with a focus on Alzheimer’s disease and Related Dementias, aging-related motor neuron disease, stroke, and epilepsy, as well as neurologic clinical trials treating patients with these disorders.神经系统疾病进展的生物学和认知标志物的方法，例如脑淀粉样蛋白和TAU，结构性脑成像，以及记忆，执行功能和其他认知领域的评估都嵌入了训练课程中。此外，在激烈的研究经验的过程中提供了全面的结构化研究教育课程，其中包括良好的临床实践，基础研究方法，抽象作者资格和海报的介绍以及统计概念和分析方法的介绍以及最常见的神经疾病的统计概念和分析方法以及流行病学和病理学评论，例如Alzeimorsers的疾病。我们的机构在全球范围内开发学术神经科医生的良好记录是，这项短期，强烈的计划通过动手介绍神经研究，对研究原理的全面审查，基于这些资源的丰富资源，从而确保这些学生在包括Alzheimer erseaser在内的老化神经系统疾病领域开发研究生涯的最佳机会。