Proof of concept study of a highly novel food fortification to boost exercise performance in younger and older adults

一种高度新颖的食品强化剂的概念验证研究，可提高年轻人和老年人的运动表现

• 批准号: 10073883
• 金额: $ 54.14万
• 依托单位: MITOCHONDRIAL SUBSTRATE INVENTION LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10073883
• 关键词: Proof; concept; study; highly; novel

A vital function of every cell in our bodies is the process of metabolism. For our cells and bodies to function, they need access to an energy carrying molecule called adenosine triphosphate (ATP). Sadly as we age our body's ability to produce sufficient ATP declines and our physical and mental wellbeing declines in parallel. One way to offset this decline is to develop effective food supplements that maintain cell metabolism (i.e. our cells' access to energy).We are developing a food supplement called Mitocholine(tm), the supplement includes three natural compounds that, when taken orally, become available to the cells to keep them energised and functional.Mitocholine(tm) has the potential to help the cells in our brain function more effectively. The Mitocholine team is currently testing this supplement in older people to see if it helps improve how their brain works and reduce the memory loss issues. This study is not yet complete, but early results show a potential positive benefit to brain health in the elderly.Mitocholine now has the potential to develop a variant of Mitocholine(tm) that is suitable to put in foods as a supplement to support the cells in our muscles and support improved ability to exercise and boost physical energy levels. This concept is important because Western diets are known to be low in key components in the Mitocholine(tm) supplement. This insufficiency is particularly challenging for pregnant women. Mitocholine(tm) has the potential to address this deficiency in our diets while also supporting physical and mental wellbeing.The aim of the proposed project is to understand if a Mitocholine(tm) containing food additive, by providing additional fuel to our muscle cells, will enhance aerobic fitness and exercise performance. This proposed research will investigate how effectively young and older adults can exercise after taking Mitocholine(tm) food additive compared to a placebo. Mitocholine will work closely with expert sports scientists at the University of Exeter to test volunteers' capacity to perform different types of exercise after taking the food supplement.If Mitocholine is able to demonstrate that the supplement works, it will be able to secure commercial sales of the supplement to specialist food producers globally.

我们体内每个细胞的重要功能是代谢过程。为了使我们的细胞和身体发挥作用，他们需要使用称为三磷酸腺苷（ATP）的能量分子。令人遗憾的是，随着我们身体使足够的ATP下降的能力，我们的身心福祉平行下降。抵消这种下降的一种方法是开发有效的食物补充剂维持细胞代谢（即我们的细胞获得能量的获取）。我们正在开发一种称为线胆碱（TM）的食物补充剂，该补充剂包括三种自然化合物，当口服口服时，可以向细胞使用，以使它们能够保持活力和功能性。促进和促胆碱（TM）可以帮助我们的大脑功能更大。线粒体团队目前正在测试老年人的这种补充剂，以查看它是否有助于改善其大脑的工作方式并减少记忆力损失问题。这项研究尚未完成，但早期结果表明，对老年人的大脑健康具有潜在的积极益处。蒙脱石现在有可能开发一种线胆碱（TM）的变体，该变体适合于食物中作为补充，以补充我们的肌肉中的细胞并支持改善运动和提高物理能量的能力。这个概念很重要，因为已知西方饮食在线胆碱（TM）补充剂中的关键成分中较低。对于孕妇而言，这种功能不全尤其具有挑战性。线粒体（TM）有可能解决我们饮食中的这种不足，同时还可以支持身体和心理健康。该项目的目的是通过为我们的肌肉细胞提供额外的燃料来了解含有食物添加剂的线粒体（TM）是否会增强有氧运动和运动表现。这项拟议的研究将研究与安慰剂相比，服用线粒体（TM）食物添加剂后，年轻人和老年人可以有效地运动。线胆碱将与埃克塞特大学的专家体育科学家紧密合作，以测试志愿者在服用食品补充剂后进行不同类型的运动的能力。如果线粒体能够证明补充剂的作品，它将能够确保全球专业食品生产商的商业销售。