Infant multisensory integration and speech development: A multimodal imaging study

婴儿多感觉整合和言语发展：多模态成像研究

• 批准号: 10436160
• 负责人: Guannan Shen
• 金额: $ 12.32万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10436160
• 关键词: 2 year old; 3 year old; Acoustics; Adult; Age; Age-Months; Area; Auditory; Auditory area; Award; Behavior assessment; Behavioral; Brain; Brain imaging; Brain region; Broca' s area; Child; Clinical; Code; Comb animal structure; Complex; Data; Databases; Development; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Early Diagnosis; Early Intervention; Equipment and supply inventories; Face; Failure; Future; Gestational Age; Goals; Imaging Techniques; Incidence; Individual; Infant; Inferior; Intervention; K-Series Research Career Programs; Knowledge; Language; Language Delays; Language Development; Language Development Disorders; Language Disorders; Learning; Life; Linguistics; Link; Lip structure; Magnetoencephalography; Measures; Modality; Movement; Multimodal Imaging; Parents; Pathway interactions; Perception; Play; Population; Premature Infant; Prevalence; Process; Research; Resources; Risk; Role; Sampling; Scientist; Sensory; Speech; Speech Delay; Speech Development; Speech Disorders; Speech Sound; Stimulus; Structure; System; Technology; Testing; Time; Training; Training Support; Visual; Visual Cortex; Voice; audiovisual speech; base; behavioral outcome; brain behavior; imaging study; improved; indexing; language outcome; multimodality; multisensory; neural circuit; neural correlate; neuromechanism; neurophysiology; recruit; relating to nervous system; response; speech processing; visual information; visual speech; visual stimulus; vocalization; white matter

Project summary Multisensory integration plays a central role in speech acquisition as most infants harness auditory and visual information to crack the language code. Disruption to multisensory processing in the first year of life is associated with later speech delay and language disorders. Although research in adults has identified several brain measures and brain regions involved in multisensory processing, how this process emerges in infants and how it is related to behavioral outcome, especially language outcome, is very much unknown. The primary objective of this Career Development Award is to support training in multimodal brain imaging in order to examine functional and structural mechanisms of multisensory development and their associations with speech acquisition and language outcomes in typically developing (TD) and preterm infants. Improved understanding of normal multisensory integration and deviations from normal will inform early diagnosis and intervention strategies for infant speech delay/disorders. The proposed award builds upon the candidate’s prior training in speech processing and multisensory perception, extending this knowledge into the domains of infant brain imaging (function and structure) and infant vocalization analysis. Aim 1 characterizes the neural bases of multisensory integration in TD and preterm infants and investigates brain-behavior associations in infants 9 to 12 months old (Time 1). Specifically, Aim 1a investigates cortical neural processes (obtained via infant magnetoencephalography (MEG)) following congruent versus incongruent audiovisual speech stimuli, with a focus on alpha activity in auditory cortex and gamma activity in Broca’s area. Aim 1b examines whether the MEG measures of multisensory processing as well as DTI measures of structural connectivity are associated with pre-verbal vocalization (i.e., canonical babbling). Aim 2b tests whether the brain measures and vocalization assessment in the first year of life predict speech/language outcome at 24 months. Finally, Exploratory Aim 3 directly compares these measures in preterm infants versus TD infants. Although the K01 study investigate complex multisensory speech mechanisms, the research is feasible given the candidate’s background and the available institutional resources (scientists and technology). Study findings are expected to inform theoretical modals of early speech development as well as provide the candidate pilot data for future R01 clinical brain imaging studies on atypical multisensory development in at-risk infant populations. The award will also provide the candidate the opportunity to obtain training in behavioral assessment of speech/language development and cutting-edge multimodal imaging techniques. The research performed and training provided by this award is critical to the candidate’s long-term goal of conducting independent research on the neurophysiological mechanisms of speech/language development and disorders.

项目摘要 大多数婴儿线束听觉和视觉 信息以破解语言代码。在生命的第一年中，对多感觉处理的破坏是 与以后的语音延迟和语言障碍有关。尽管成年人的研究已经确定了几个 大脑测量和大脑区域参与多感官处理，婴儿如何出现该过程 它与行为结果，尤其是语言结果的关系是非常未知的。 该职业发展奖的主要目标是支持多模式大脑成像中的培训 为了检查多感官发展的功能和结构机制及其 典型发展（TD）和早产的语音获取和语言结果的关联 婴儿。对正常的多感官整合和偏离正常的偏离的了解将有所了解 婴儿语音延迟/疾病的早期诊断和干预策略。 拟议的奖项是基于候选人在语音处理和多感官方面的先前培训的基础 感知，将这些知识扩展到婴儿脑成像（功能和结构）的领域， 婴儿发声分析。 AIM 1表征了TD中多感官整合的神经底座 早产婴儿并研究了9至12个月大的婴儿（时间1）的婴儿的脑行为联系。 特别是，AIM 1A研究了皮质神经过程（通过婴儿磁性摄影获得 （MEG））遵循一致与不一致的视听语音刺激，重点是 Broca地区的听觉皮层和伽马活动。目标1B考试MEG测量是否 多感觉处理以及结构连通性的DTI测量与言语有关 发声（即规范性的babling）。 AIM 2B测试大脑测量和发声评估是否 在生命的第一年，可以预测24个月的语音/语言结果。最后，探索目标3直接 比较早产儿与TD婴儿的这些措施。尽管K01研究调查了复杂 鉴于候选人的背景和可用 机构资源（科学家和技术）。研究结果有望告知理论模式 早期语音开发以及为未来R01临床大脑成像的候选飞行员数据提供 关于高危婴儿种群非典型多感官发展的研究。 该奖项还将为候选人提供机会，以获得行为评估的培训 语音/语言发展和尖端的多模式成像技术。研究进行了， 该奖项提供的培训对于候选人进行独立研究的长期目标至关重要 关于语音/语言发展和疾病的神经生理机制。