Identifying circuit-level neuromarkers of smoking dependence that change in response to intervention

识别因干预而变化的吸烟依赖的回路水平神经标志物

基本信息

批准号：
10434823
负责人：
Andrea Hobkirk
金额：
$ 16.31万
依托单位：
PENNSYLVANIA STATE UNIV HERSHEY MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-15 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10434823
关键词：
Address Adult Award Behavior assessment Behavioral Brain Cigarette Clinical Decision Making Dependence Development Double-Blind Method Equipment Evaluation Evaluation Research Event Exposure to Functional Magnetic Resonance Imaging Goals Human Image Impairment Intervention K-Series Research Career Programs Knowledge Lead Magnetic Resonance Imaging Measurable Measures Mentors Mentorship Motivation Neurobiology Neurocognitive Nicotine Odors Outcome Participant Performance Positioning Attribute Process Randomized Randomized Controlled Trials Reporting Research Research Personnel Research Training Respiration Rewards Science Smell Perception Smoke Smoker Smoking Stimulus Time Tobacco Tobacco use Training Treatment outcome United States Visual Withdrawal brain circuitry cigarette smoke craving cue reactivity executive function functional MRI scan incentive salience interest longitudinal analysis low nicotine content cigarette neural circuit neurobehavioral nicotine replacement non-smoking novel patient oriented post-doctoral training professor public health relevance randomized trial reinforcer relating to nervous system response smoking addiction smoking cessation smoking cue stimulant dependence success tobacco regulatory science

项目摘要

Abstract Although half of the 37 million adult smokers in the US attempt to quit each year, only an estimated 3% are successful. Smoking is associated with changes in brain circuitry that drive incentive salience valuation and executive control. Over time, the incentive salience of smoking cues become enhanced, while the salience of non-smoking rewards are diminished. Further, executive control over smoking motivation and drives becomes impaired. While functional magnetic resonance imaging (fMRI) has identified brain circuitry associated with incentive salience valuation and executive control, we currently have a limited understanding of how this brain circuitry changes with cessation treatment and reductions in dependence. Characterizing changes in neurocircuitry during smoking cessation has the potential to inform the development of targeted neuropharmacological, behavioral, and brain stimulation cessation interventions. This proposal aims to provide the candidate with training and research to address this critical gap in our identification of modifiable neuromarkers of smoking dependence. The candidate will conduct a double-blind, 6-week, randomized trial of very low nicotine content cigarettes among smokers while collecting longitudinal fMRI measures over 3 time- points. The MRI tasks will engage incentive salience valuation of smoking and non-smoking rewards and executive control through inhibition and decision making. These tasks will include a respiration-triggered-event- related sequence to measure smoking odor cue reactivity, an understudied, but potentially potent secondary smoking reinforcer. With a mentorship team of experts in tobacco use, human olfaction, fMRI, and longitudinal analysis and the support of the Penn State Tobacco Center of Regulatory Science, the candidate will emerge as a patient-oriented clinical researcher contributing to our neurobehavioral understanding of smoking dependence and tobacco use.

抽象的尽管美国每年有3700万成年吸烟者中有一半试图戒烟，但估计只有3％成功的。吸烟与脑电路的变化有关，以推动激励显着性评估和执行控制。随着时间的流逝，吸烟提示的激励显着性得到了增强，而显着性非吸烟奖励减少。此外，对吸烟动机和驱动器的行政控制变得受损。虽然功能磁共振成像（fMRI）已经确定了与激励性显着估值和执行控制，我们目前对这种大脑的了解有限电路随着停止处理和依赖的减少而变化。表征变化戒烟期间的神经通路有可能告知有针对性的发展神经药物，行为和大脑刺激戒烟干预措施。该建议旨在提供培训和研究的候选人，以解决我们对可修改的识别时的这一关键差距吸烟依赖的神经标志物。候选人将进行双盲，6周的随机试验吸烟者中的尼古丁含量非常低点。 MRI任务将对吸烟和非吸烟奖励的激励显着性评估以及通过抑制和决策来控制执行控制。这些任务将包括呼吸触发的事件 - 测量吸烟气味提示反应性的相关顺序，研究了，但潜在的次要吸烟增强剂。与烟草使用，人类嗅觉，fMRI和纵向专家的指导团队分析和宾夕法尼亚州烟草科学中心的支持，候选人将出现作为一名以患者为导向的临床研究人员，为我们的神经行为理解做出了贡献依赖和烟草使用。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effect of menthol on nicotine reduction: Pooled results from two double-blind randomized controlled trials.

DOI：
10.1016/j.brainresbull.2022.08.019
发表时间：
2022-10-15
期刊：
Brain research bulletin
影响因子：
3.8
作者：
通讯作者：

Tobacco Use Changes and Perceived Health Risks among Current Tobacco Users during the COVID-19 Pandemic.

DOI：
10.3390/ijerph18041795
发表时间：
2021-02-12
期刊：
International journal of environmental research and public health
影响因子：
0
作者：
Yingst JM;Krebs NM;Bordner CR;Hobkirk AL;Allen SI;Foulds J
通讯作者：
Foulds J

Dependence and Use Characteristics of Adult JUUL Electronic Cigarette Users.

DOI：
10.1080/10826084.2020.1834582
发表时间：
2021
期刊：
Substance use & misuse
影响因子：
2
作者：
Yingst J;Foulds J;Hobkirk AL
通讯作者：
Hobkirk AL

COVID-19 Vaccination Uptake and Hesitancy Among Current Tobacco Users.

DOI：
10.1177/1179173x211068027
发表时间：
2021
期刊：
Tobacco use insights
影响因子：
2.2
作者：
Krebs NM;D'Souza G;Bordner C;Allen SI;Hobkirk AL;Foulds J;Yingst JM
通讯作者：
Yingst JM

A Comparison of Vaping Behavior, Perceptions, and Dependence among Individuals Who Vape Nicotine, Cannabis, or Both.

DOI：
10.3390/ijerph191610392
发表时间：
2022-08-20
期刊：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
影响因子：
0
作者：
Saran, Savreen K.;Salinas, Kalin Z.;Foulds, Jonathan;Kaynak, Ovgu;Hoglen, Brianna;Houser, Kenneth R.;Krebs, Nicolle M.;Yingst, Jessica M.;Allen, Sophia I.;Bordner, Candace R.;Hobkirk, Andrea L.
通讯作者：
Hobkirk, Andrea L.