Transforming SequenceServer: unlocking new revenue opportunities by incorporating collaborative tools and molecular cloning capabilities

改造 SequenceServer：通过整合协作工具和分子克隆功能释放新的收入机会

• 批准号: 10072808
• 金额: $ 6.37万
• 依托单位: PRAGMATIC GENOMICS LIMITED
• 依托单位国家: 英国
• 项目类别: Grant for R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10072808
• 关键词: Transforming; SequenceServer; unlocking; new; revenue

The commoditisation and decentralisation of DNA sequencing has completely changed biological research, with similar changes underway in biological engineering across agroindustry, biotech, pharma, diagnostics and treatment of disease. A key challenge that accompanies the resulting opportunities is for staff scientists to make sense of the spectacular amounts of data that they can now easily generate.The BLAST analysis algorithm has been foundational to biological engineering since 30 years -- it is used for comparing DNA or protein sequences. Historically, it has typically been applied in a "google search"-type manner where scientists query a public database using a central server funded by the US National Institutes of health. The decentralisation of DNA sequencing challenges this model.We developed SequenceServer Cloud, a software that enables individuals and teams of biologists to perform BLAST analysis of proprietary DNA and protein-sequence data. Our software's intuitive user experience and advanced visualisation capabilities accelerate discovery across agroindustry, pharma, biotech, academia and non-profit sectors.We will use InnovateUK funding to create two new products that complement SequenceServer Cloud's existing functionality. These new products will enable work and increase productivity of scientists and technicians working across biological engineering areas, including for molecular diagnostics, improving agricultural practices, and synthetic biology.

DNA测序的商品化和权力下放已经完全改变了生物学研究，跨农业发展，生物技术，制药，诊断和疾病治疗的生物工程发生了类似的变化。由此产生的机会伴随的一个关键挑战是，员工科学家要理解它们现在可以轻松生成的大量数据。爆炸分析算法自30年以来一直是生物工程的基础 - 用于比较DNA或蛋白质序列。从历史上看，它通常是以“ Google搜索”类型的方式应用的，在该方式中，科学家使用美国国立卫生研究院资助的中央服务器查询公共数据库。 DNA测序的权力下放挑战了该模型。我们开发了序列服务器云，该软件使个人和生物学家团队能够对专有DNA和蛋白质序列数据进行爆炸分析。我们的软件的直观用户体验和高级可视化功能加速了跨农业人员，制药，生物技术，学术界和非营利性领域的发现。我们将使用Innovateuk资金来创建两个新产品，以补充Sequenceserver Cloud现有功能的新产品。这些新产品将实现工作并提高在生物工程领域工作的科学家和技术人员的生产率，包括分子诊断，改善农业实践和合成生物学。