Inorganic functional immunomodulators targeting Th-17 immune response for vaccines and cell therapies

用于疫苗和细胞疗法的针对 Th-17 免疫反应的无机功能性免疫调节剂

基本信息

批准号：
10072512
负责人：
金额：
$ 6.26万
依托单位：
IUVANTIUM LIMITED
依托单位国家：
英国
项目类别：
Grant for R&D
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=10072512
关键词：
Inorganic functional immunomodulators targeting Th

项目摘要

The project aims to deliver a new class of inorganic materials that profoundly modulate immune responses. These are based on an inorganic material platform to improve the quality and efficacy of current and next generation vaccines and cell therapies targeting infectious diseases and cancers.The functional material explored allows precise control of the physicochemical properties of the particles by applying engineering principles during the synthesis step, enabling tailor-made compounds specifically designed to elicit the optimum immune response for the respective disease targets. The immune response of these compounds proved to be predictable based purely on the properties of the functional materials enabling rapid in-silico screening of best candidates, accelerating development timelines for a broad range of modalities and probability of success in clinical studies.In this project we will apply engineering principles to immunobiological systems by rationally design inorganic immunomodulators and screen them for their immunological response in relevant assays. It will specifically target the special types of immunity needed for defence against many bacterial and fungal pathogens, and which are particularly important for defence at mucosal sites where most of these pathogens infect (e.g. lungs, gut and genital tract).

该项目旨在提供一类新的无机材料，以深刻调节免疫反应。这些基于一个无机材料平台，以提高针对感染性疾病和癌症的当前和下一代疫苗和细胞疗法的质量和功效。探索的功能材料允许精确控制粒子的物理化学特性，通过在合成步骤中应用工程原理，使量身定制的构成型物质响应以极大的响应为特定的疾病，从而使颗粒的物理化学特性具有特定的反应。 The immune response of these compounds proved to be predictable based purely on the properties of the functional materials enabling rapid in-silico screening of best candidates, accelerating development timelines for a broad range of modalities and probability of success in clinical studies.In this project we will apply engineering principles to immunobiological systems by rationally design inorganic immunomodulators and screen them for their immunological response in relevant assays.它将特别针对防御许多细菌和真菌病原体所需的特殊类型的免疫力，这对于大多数这些病原体感染的粘膜部位尤其重要（例如肺，肠道和生殖道）。