Administrative Supplement for Gulf Coast Center for Precision Environmental Health

墨西哥湾沿岸精准环境健康中心行政补充

• 批准号: 10436634
• 负责人: Cornelis Johan Elferink
• 金额: $ 120.34万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436634
• 关键词: Address; Administrative Supplement; Adult; Age-Months; Animals; Area; Automobile Driving; Biological Markers; Blood; Brain; ChIP-seq; Chemicals; Communication; Communities; Control Groups; Core Facility; Country; Data; Development; Disasters; Discipline; Disease; Enhancers; Environment; Environmental Exposure; Environmental Health; Epigenetic Process; Exhibits; Exposure to; Faculty; Female; Fostering; Funding; Gases; Gene Expression; Gene Expression Profile; Gene Expression Profiling; Genetic; Genetic Transcription; Genomics; Goals; Grant; Health; Health Policy; Histones; Home; Human; Individual; Industry; Infrastructure; Institution; Intervention; Leadership; Life; Link; Medical center; Mentors; Modification; Mus; National Institute of Environmental Health Sciences; Neurocognitive; Oils; Outcome; Pattern; Phenotype; Pilot Projects; Plants; Process; Promoter Regions; Research; Research Activity; Research Personnel; Research Support; Resources; Risk; Seasons; Site; Technology; Testing; Tetrachlorodibenzodioxin; Texas; Time; Tissues; Toxicant exposure; Training Programs; Translational Research; Translations; Walkers; base; career development; catalyst; community engagement; design; early life exposure; epigenome; epigenomics; experience; fine particles; genome-wide; gulf coast; health science research; histone modification; improved; inter-institutional; male; member; next generation; programs; promoter; ranpirnase; research and development; response; sex; skills; superfund site; transcriptome; transcriptome sequencing; transcriptomics

ABSTRACT: OVERALL The Houston-Galveston area is home to over a dozen Superfund sites, and is a hub for the petrochemical industry with 500 chemical plants, 10 refineries and >6000 miles of oil, gas and chemical pipelines in what has become the country’s largest energy corridor. The area is also home to the largest medical center in the world, the Texas Medical Center. Thus, both the need, and size of the opportunity, for an NIEHS Environmental Health Sciences (EHS) Core Center (EHS-CC) in this region is great. As the EHS-CC for the Texas Medical Center, the Gulf Coast Center for Precision Environmental Health (GC-CPEH) will be the focal point and catalyst for impactful EHS research, multi-directional communication with local communities and stakeholders, and the engine driving translation of precision environmental health research advances to improve human health. The Goals for the GC-CPEH are to 1: Integrate and catalyze impactful EHS research across disciplines and institutions of the Texas Medical Center, and promote the next-generation of EHS researchers; 2: Provide inter- institutional access to resources and cutting-edge technologies to accelerate translation, and reverse translation, of research advances to improve human environmental health; 3: Support and empower community engagement across the Gulf Coast region by linking community stakeholders and investigators in multi-directional communication activities that inform GC-CPEH research; 4: Enable rapid response research activities during and after environmental disasters in the Gulf Coast region. The GC-CPEH has 34 Full members, 17 of whom have active NIEHS-funded grant support with an annual direct funding base >$5 million. The Center will support precision environmental health research through its Thematic Focus Areas: Early Life Genetic and Epigenetic Environment Interactions; Mechanisms and Interventions in Human Environmental Disease; and Disaster Research Response. The GC-CPEH will also promote research through its Pilot Project Program, accelerate research advances with seamless access to Next-gen technologies via the PIPELINE Facility Core and an IHSFC that will promote translational research; activities facilitated by Navigators and the Matching Funds Core Utilization Program. The Administrative Core, composed of highly seasoned EHS leaders, provides organizational infrastructure, and mentoring for junior faculty that includes a Career Development Leaders-in-Training program to promote development of research and professional leadership skills. An experienced and vibrant CEC will foster multi-directional communication with communities and stakeholders, and inform environmental health policy for the Gulf Coast Region.

摘要：总体 休斯顿 - 加尔维斯顿地区拥有十多个超级基金地点，并且是石化的枢纽 具有500种化工厂，10个炼油厂和> 6000英里的油，天然气和化学管道的行业 成为该国最大的能源走廊。该地区也是世界上最大的医疗中心的所在地 德克萨斯州医疗中心。这是NIEHS环境健康的需求和机会的规模 该地区的科学（EHS）核心中心（EHS-CC）很棒。作为德克萨斯医学中心的EHS-CC， 墨西哥湾沿岸精密环境健康中心（GC-CPEH）将成为焦点和催化剂 有影响力的EHS研究，与当地社区和利益相关者的多向沟通以及 精确环境健康研究的发动机驱动翻译发展，以改善人类健康。这 GC-CPEH的目标为1：整合并催化跨学科和 得克萨斯州医疗中心的机构，并促进了EHS研究人员的下一代； 2：提供 - 机构访问资源和尖端技术以加速翻译并逆转 翻译，研究的进步，以改善人类环境健康； 3：支持和授权 通过将社区利益相关者和调查人员联系起来，整个墨西哥湾沿岸地区的社区参与 多个方向交流活动为GC-CPEH研究提供了信息； 4：启用快速响应研究 墨西哥湾沿岸地区环境灾难期间和之后的活动。 GC-CPEH有34个满 成员，其中17名活跃于NIEHS资助的赠款支持，年度直接资助基础> 500万美元。 该中心将通过其主题重点领域支持精确的环境健康研究：早期生活 遗传和表观遗传环境相互作用；人类环境的机制和干预措施 疾病;和灾难研究反应。 GC-CPEH还将通过其试点项目促进研究 程序，通过管道无缝访问下一代技术，加速研究进步 设施核心和IHSFC将促进转化研究；导航员准备的活动和 匹配资金核心利用计划。由经验丰富的EHS组成的行政核心 领导者，为包括职业的初级教师提供组织基础设施和心理 培训计划的发展领导者旨在促进研究和专业领导的发展 技能。经验丰富且充满活力的CEC将促进与社区和 利益相关者，并为墨西哥湾沿岸地区的环境卫生政策提供信息。