Administrative Supplement for Gulf Coast Center for Precision Environmental Health

墨西哥湾沿岸精准环境健康中心行政补充

• 批准号: 10436634
• 负责人: Cornelis Johan Elferink
• 金额: $ 120.34万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436634
• 关键词: Address; Administrative Supplement; Adult; Age-Months; Animals; Area; Automobile Driving; Biological Markers; Blood; Brain; ChIP-seq; Chemicals; Communication; Communities; Control Groups; Core Facility; Country; Data; Development; Disasters; Discipline; Disease; Enhancers; Environment; Environmental Exposure; Environmental Health; Epigenetic Process; Exhibits; Exposure to; Faculty; Female; Fostering; Funding; Gases; Gene Expression; Gene Expression Profile; Gene Expression Profiling; Genetic; Genetic Transcription; Genomics; Goals; Grant; Health; Health Policy; Histones; Home; Human; Individual; Industry; Infrastructure; Institution; Intervention; Leadership; Life; Link; Medical center; Mentors; Modification; Mus; National Institute of Environmental Health Sciences; Neurocognitive; Oils; Outcome; Pattern; Phenotype; Pilot Projects; Plants; Process; Promoter Regions; Research; Research Activity; Research Personnel; Research Support; Resources; Risk; Seasons; Site; Technology; Testing; Tetrachlorodibenzodioxin; Texas; Time; Tissues; Toxicant exposure; Training Programs; Translational Research; Translations; Walkers; base; career development; catalyst; community engagement; design; early life exposure; epigenome; epigenomics; experience; fine particles; genome-wide; gulf coast; health science research; histone modification; improved; inter-institutional; male; member; next generation; programs; promoter; ranpirnase; research and development; response; sex; skills; superfund site; transcriptome; transcriptome sequencing; transcriptomics

ABSTRACT: OVERALL The Houston-Galveston area is home to over a dozen Superfund sites, and is a hub for the petrochemical industry with 500 chemical plants, 10 refineries and >6000 miles of oil, gas and chemical pipelines in what has become the country’s largest energy corridor. The area is also home to the largest medical center in the world, the Texas Medical Center. Thus, both the need, and size of the opportunity, for an NIEHS Environmental Health Sciences (EHS) Core Center (EHS-CC) in this region is great. As the EHS-CC for the Texas Medical Center, the Gulf Coast Center for Precision Environmental Health (GC-CPEH) will be the focal point and catalyst for impactful EHS research, multi-directional communication with local communities and stakeholders, and the engine driving translation of precision environmental health research advances to improve human health. The Goals for the GC-CPEH are to 1: Integrate and catalyze impactful EHS research across disciplines and institutions of the Texas Medical Center, and promote the next-generation of EHS researchers; 2: Provide inter- institutional access to resources and cutting-edge technologies to accelerate translation, and reverse translation, of research advances to improve human environmental health; 3: Support and empower community engagement across the Gulf Coast region by linking community stakeholders and investigators in multi-directional communication activities that inform GC-CPEH research; 4: Enable rapid response research activities during and after environmental disasters in the Gulf Coast region. The GC-CPEH has 34 Full members, 17 of whom have active NIEHS-funded grant support with an annual direct funding base >$5 million. The Center will support precision environmental health research through its Thematic Focus Areas: Early Life Genetic and Epigenetic Environment Interactions; Mechanisms and Interventions in Human Environmental Disease; and Disaster Research Response. The GC-CPEH will also promote research through its Pilot Project Program, accelerate research advances with seamless access to Next-gen technologies via the PIPELINE Facility Core and an IHSFC that will promote translational research; activities facilitated by Navigators and the Matching Funds Core Utilization Program. The Administrative Core, composed of highly seasoned EHS leaders, provides organizational infrastructure, and mentoring for junior faculty that includes a Career Development Leaders-in-Training program to promote development of research and professional leadership skills. An experienced and vibrant CEC will foster multi-directional communication with communities and stakeholders, and inform environmental health policy for the Gulf Coast Region.

摘要：总体 休斯顿 - 加尔维斯顿地区拥有十多个超级基金的家园，是石化的枢纽 具有500种化工厂，10个炼油厂和> 6000英里的油，天然气和化学管道的行业 成为该国最大的能源库里奇。 因此，得克萨斯州医疗中心。 科学（EHS）核心中心（EHS-CC）在德克萨斯医学中心的EHS-CC中 墨西哥湾沿岸Precisis环境健康中心（GC-CPEH）将成为焦点和催化剂 Impactoful EHS研究，与当地社区和利益相关者的多向沟通以及您 驾驶精确健康研究的转化可以改善人类健康 GC-CPEH的目标为1：整合并促进跨学科的影响EHS研究 德克萨斯州医疗中心的工厂，并促进EHS研究人员的下一代； 将资源和尖端技术的启用，以加速翻译和逆转 翻译，改善人类环境健康的研究； 3：支持和授权 通过将社区利益相关者和调查人员联系起来，整个墨西哥湾沿岸地区的社区英语 多个方向的交流活动，为GC-CPEH研究提供了信息； 墨西哥湾沿岸地区的环境灾难期间的活动。 成员，其中17名积极的NIEHS资助了赠款支持，直接资助基础> 500万美元。 该中心将支持精确的环境健康研究Thematich Thematich焦点领域：早期生活 遗传和表观遗传环境相互作用； 疾病和灾难研究。 程序，通过管道加速研究，并通过无缝到下一代技术进行进步 设施核心和IHSFC IHSFC将促进导航员和您的活动； 匹配资金核心利用计划。 领导者，提供组织基础设施和为初级教师提供指导，包括职业 培训计划的发展领导者旨在促进研究和专业领导的发展 技能。 利益相关者，并为墨西哥湾沿岸地区的环境卫生提供信息。