Advanced Modelling Platform with Moving Ventricular Walls for Increasing Speed to Market of Heart Pumps

具有移动心室壁的先进建模平台可加快心脏泵的上市速度

• 批准号: 10071797
• 金额: $ 30.87万
• 依托单位: CALON CARDIO-TECHNOLOGY LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10071797
• 关键词: Advanced; Modelling; Platform; Moving; Ventricular

Left Ventricular Assist Devices (LVADs) are vital medical devices in aiding patients with advanced Heart Failure (HF). Bringing innovative heart pumps to market is a lengthy process, typically taking \>10 years. Development times are extended due to the complexity of the real-world cardiovascular system (CS), in which the pump operates, and limitations in current analytical tools for determining pump performance prior to _in vivo_ testing. This project will remove these limitations with an innovative coupled LVAD and CS model, capturing the Moving Ventricular Wall (MVW) of the Left Ventricle (LV) and valve openings.Understanding how an LVAD works across the range of physiological pulsatile flow conditions expected for _in vivo_ animal tests and patients with Severe Heart Failure (SHF) or in recovery, is critical to the successful launch of an LVAD.Often animal models are significantly different physiologically from SHF patients and manufacturers use other techniques such as Computational Fluid Dynamics (CFD) and Mock Loops (MLs) to provide confidence to take a VAD to human trials. Understanding physiology allows complex algorithms to be implemented within the device controller to tailor treatments and warn clinicians of potential Adverse Events (AEs).Calon, through partnerships, has created a robust CFD modelling capability for LVADs and Calon has developed a zero-dimensional (0D) mathematical CS model, incorporating the LVAD. This allows Calon to simulate flows through the pump and analyse shear stress, residence time and blood damage in pulsatile conditions. We have shown, with simplistic models, the need to include MVWs, which perturbs the fluid as it enters the pump inlet.Calon will develop a 3D coupled CFD model of the LV with MVWs and the pump in situ. The 0D model will define the flow in and out of the valves, which will form the boundary conditions for the CFD model. The movement of the heart will be derived from cardiac imaging. The 0D model will befurther developed with data from patient populations, allowing Calon to better understand the performance of the pump in realistic rheology and physiology, which will ultimately improve the safety of the LVAD. Furthermore, Calon will conduct a review of the data generated and the available literature to explore algorithms used to improve patient outcomes and aid clinicians.

左心室辅助装置（LVADS）是帮助患有晚期心力衰竭（HF）的患者的重要医疗设备。将创新的心脏泵推向市场是一个漫长的过程，通常需要\> 10年。由于泵操作的现实世界心血管系统（CS）的复杂性，开发时间是延长的，并且在当前分析工具中限制了在_in vivo_ testing之前确定泵的性能。该项目将通过创新的LVAD和CS模型来消除这些局限性，从而捕获左心室（LV）和阀门的移动心室壁（MVW）。理解LVAD在整个生理脉动流动范围内如何工作，以期为_ In vivo _动物造成的动物造成的脉动流量（shf）的脉动流动预期（shf）的恢复（shf）的恢复（IS LV）恢复（IS conviews），是恢复的，该模型是在恢复的，该模型是恢复的。与SHF患者和制造商在生理上有显着不同的不同技术，例如计算流体动力学（CFD）和模拟环（MLS），以提供对人类试验进行VAD的信心。理解生理学允许在设备控制器中实施复杂的算法，以量身定制治疗，并警告临床医生潜在的不良事件（AES）。Calon通过合作伙伴关系为LVADS和CALON创建了强大的CFD CFD建模能力，而Calon开发了零维（0D）数学CS模型，该模型将LVAD融合在一起。这使Calon能够模拟泵的流量，并在脉动条件下分析剪切应力，停留时间和血液损伤。我们已经通过简单的模型表明，需要包括MVW，该模型进入泵入口时会使流体变为流体。CALON将开发具有MVWS的LV的3D耦合CFD模型，并原位泵。 0D模型将定义流入和输出阀的流，这将形成CFD模型的边界条件。心脏的运动将来自心脏成像。 0D模型将通过患者人群的数据开发，使Calon可以更好地了解泵在现实的流变和生理学中的性能，这最终将提高LVAD的安全性。此外，Calon将对生成的数据和可用文献进行审查，以探索用于改善患者结局和AID临床医生的算法。