Bruker D8 VENTURE Diffractometer

布鲁克 D8 VENTURE 衍射仪

• 批准号: 10429832
• 负责人: Bo Li
• 金额: $ 42.83万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10429832
• 关键词: 12 year old; Age; Area; Biochemistry; Biology; Boston; Charge; Chemicals; Consumption; Coupled; Crystallization; Data; Data Collection; Faculty; Funding; Light; Measurement; Methods; Modeling; Organic Chemistry; Production; Radiation; Research; Research Activity; Roentgen Rays; Sampling; Services; Source; Structure; Temperature; Time; United States National Institutes of Health; Work; X-Ray Crystallography; bioactive natural products; college; density; detector; drug candidate; experimental study; improved; instrument; member; programs; quantum; small molecule; tool

Project Summary/Abstract The Center for X-ray Crystallography at Boston College is seeking funds to purchase a Bruker D8 VENTURE Diffractometer coupled with duo ImuS radiation sources (Mo and Cu) and a PHOTON III detector for small molecule structural characterization. Currently the only single-crystal X-ray diffractometer at Boston College is an 12-year old Bruker APEX II DUO diffractometer purchased in 2009. This essential workhorse instrument has become unreliable with age and heavy usage. Due to discontinuation of production of this model instrument and a lack of replacement parts, Bruker will end service support for our current instrument starting June 1, 2021. The Bruker D8 VENTURE allows users to collect high-quality charge density data with Mo radiation and to exploit all the advantages of the Cu wavelength for absolute structure determinations and diffraction experiments on small organic crystals. This new instrument will provide indispensable analytical support for a very broad range of research programs from eight faculty members, among them, seven are NIH-supported. Research activities are concentrated primarily in the areas of synthetic organic chemistry, and biochemistry/chemical biology, targeted to develop methods for the synthesis of bioactive natural products, small molecule drug candidates, and macromolecular biomolecules. Such projects depend highly on the acquisition of structural information of intermediate and end products. X-ray crystallography is an indispensable tool for this work, and in many cases, the only reliable method to obtain structural information. The combination of ultra brightness of the ImuS sources, with the quantum-limited sensitivity of the PHOTON III detector, will not only greatly improve our capability on small and weakly-diffracted samples, but also fulfil the steadily rising needs for absolute configuration determinations on molecules that only contain light atoms. Users are more likely to get crystal structures from samples that were previously found to be unsuitable or too small. Time consuming experiments such as variable temperature measurements will become more practical and data collection on metastable crystals will be amenable, thanks to faster acquisition time.

项目摘要/摘要 波士顿学院的X射线晶体学中心正在寻求资金购买Bruker D8 Venture 衍射仪与二人组IMUS辐射源（MO和CU）和小的光子III检测器结合在一起 分子结构表征。目前，波士顿学院唯一的单晶X射线衍射仪是 2009年购买的一个12岁的布鲁克Apex II二人组衍射仪。 随着年龄和大量使用而变得不可靠。由于停用了该模型工具的生产和 缺乏替换零件，布鲁克将从2021年6月1日开始为我们当前的乐器提供服务支持。 Bruker D8 Venture允许用户通过MO辐射收集高质量的充电密度数据并利用 CU波长的所有优点用于绝对结构的确定和衍射实验 小有机晶体。这种新工具将为非常广泛的范围提供必不可少的分析支持 在八名教职员工的研究计划中，其中七个是NIH支持的。研究活动 主要集中在合成有机化学和生物化学/化学生物学领域 针对开发合成生物活性天然产物的方法，小分子药物， 和大分子生物分子。这样的项目在很大程度上取决于获取的结构信息 中间产品和最终产品。 X射线晶体学是这项工作必不可少的工具，在许多情况下， 获取结构信息的唯一可靠方法。 IMUS源超亮度的结合， 使用光子III检测器的量子限制灵敏度，不仅会极大地提高我们的能力 小型且弱分化的样本，但也满足了绝对配置的稳定上升需求 对仅包含光原子的分子的测定。用户更有可能从中获得水晶结构 以前发现不合适或太小的样品。耗时的实验，例如变量 温度测量将变得更加实用，并且在亚稳态晶体上收集数据 符合更快的收购时间。